Sesquiterpene lactones from Elephantopus mollis and their anti-inflammatory activities

Wu, Zhong‐Nan; Zhang, Yubo; Chen, Neng‐Hua; Li, Mo-Jiao; Li, Man‐Mei; Tang, Wei; Zhuang, Ling; Wang, Guo‐Cai

doi:10.1016/j.phytochem.2017.01.020

Cited by 29 publications

(34 citation statements)

References 12 publications

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“…Recently, sesquiterpene lactones in medicinal plants have been attracted much attention for their diverse biological activities, including anti-cancer (Alexandre Schefer et al, 2017), anti-inflammatory (Wu et al, 2018(Wu et al, , 2017, and antibacterial effects (Labed et al, 2019). Specifically, their anti-cancer activities have gained increasing attention from many researchers.…”

Section: Introductionmentioning

confidence: 99%

Eupalinolide J induces apoptosis, cell cycle arrest, mitochondrial membrane potential disruption and DNA damage in human prostate cancer cells

Dai

et al. 2020

J. Toxicol. Sci.

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-Eupalinolide J (EJ) is a new sesquiterpene lactone isolated from Eupatorium lindleyanum DC. In the present study, we investigated the anti-cancer activity of EJ on cell proliferation in human prostate cancer cells. The MTT results indicated that EJ showed marked anti-proliferative activity in PC-3 and DU-145 cells in a dose-and time-dependent manner. DAPI staining analysis demonstrated that this effect was mediated by induction of cell apoptosis. Flow cytometric analysis indicated a significant increase in apoptotic cells, cell cycle arrest at G0/G1 phase and disruption of mitochondrial membrane potential (MMP) after EJ treatment. Meanwhile, the activation of caspase-3 and caspase-9 was visibly observed. Furthermore, our results demonstrated that the expression levels of γH2AX, p-Chk1 and p-Chk2 were significantly up-regulated, suggesting the induction of DNA damage responses in EJ-treated prostate cancer cells. The above results indicated that EJ exhibited effective anti-cancer activity in vitro. It could be a promising candidate agent for the clinical treatment of prostate cancer.

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Section: Introductionmentioning

confidence: 99%

Eupalinolide J induces apoptosis, cell cycle arrest, mitochondrial membrane potential disruption and DNA damage in human prostate cancer cells

Dai

et al. 2020

J. Toxicol. Sci.

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“…Seven patent applications are registered in the European Patent Office for the use of the plant as a medicine (Li, Ye, Wang, Li, & Wang, 2016a;Li, Ye, Wang, Li, & Wang, 2016b;Hou, Lin, Wu, Chen, & Siao, 2012;Medeiros, Senna-Vale, Andreata, & Fernandes, 2008, Umishio, Maeda, & Kobayashi, 2006Kondo et al, 2000) due to its hepatoprotective (Ho, Yeap, Ho, Abdul Rahim, & Alitheen, 2012;Kabiru & Por 2013), antioxidant (Clemes, Beirith, & Zeni, 2015), anti-inflammatory (Wu et al, 2017), antimicrobial, antileishmaniasis, bone regeneration (Kabiru & Por, 2013;Ngueguim et al, 2012;Sosa et al, 2016), temperature-lowering, and antihypertensive properties, as well as its effects on intestinal transit (Poli et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Maturation, processing and seed storage of Elephantopus mollis Kunth Maturação, processamento e armazenamento de sementes de Elaphantopus mollis Kunth.

et al. 2019

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Elephantopus mollis Kunth. (Asteraceae) é uma espécie medicinal aromática, nativa da América do Sul e Central com propriedades hepatoprotetora, anti-inflamatória, antitumoral e leishmanicida. Objetivou-se avaliar a maturação, ponto de colheita, beneficiamento e armazenamento de sementes desta espécie visando contribuir com a produção do recurso fitoterápico. Coletou-se capítulos florais entre 7 e 56 dias após a antese, sendo avaliado a massa seca, teor de umidade e germinação das sementes e correlacionados com caracteres morfológicos dos capítulos florais. Avaliou-se o beneficiamento dos capítulos florais por meio de peneiras e soprador de sementes, com averiguação da pureza, peso de mil sementes, germinação e valor cultural das sementes. Determinou-se potencial germinativo de sementes armazenadas por até 18 meses à temperatura ambiente e refrigerado e correlacionado com teste de envelhecimento acelerado. O ponto de colheita ocorre aos 49 dias após a antese e pode ser identificado a campo pela coloração marrom das brácteas interflorais. Pode-se obter sementes com valor cultural acima de 80% com o uso de peneira 0,59 mm e soprador de sementes. As sementes podem ser armazenadas por 12 meses a frio sem queda do potencial germinativo. O teste de envelhecimento acelerado permite estimar a viabilidade do armazenamento das sementes por 18 meses.

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“…E. mollis and E. scaber are the most popular species of the genus [ 2 , 3 ]. They have been screened for their pharmacological and phytochemical profiles [ 1 , 4 , 5 ]. Elephantopus species are sources of a class of sesquiterpenoid lactones named elephantopus-type lactones with a furane ring (C-2/C-5) in germacranolides [ 1 , 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…They have been screened for their pharmacological and phytochemical profiles [ 1 , 4 , 5 ]. Elephantopus species are sources of a class of sesquiterpenoid lactones named elephantopus-type lactones with a furane ring (C-2/C-5) in germacranolides [ 1 , 2 , 3 , 4 , 5 , 6 ]. They also produce glaucoside- and guaianolide-type lactones even in less amount alongside phenolic compounds and other terpenes [ 1 , 4 , 5 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Elephantopus species are sources of a class of sesquiterpenoid lactones named elephantopus-type lactones with a furane ring (C-2/C-5) in germacranolides [ 1 , 2 , 3 , 4 , 5 , 6 ]. They also produce glaucoside- and guaianolide-type lactones even in less amount alongside phenolic compounds and other terpenes [ 1 , 4 , 5 , 7 ]. Sesquiterpene lactones have been proven to be the active principle of the plant against various diseases [ 1 , 4 , 5 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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LC-ToF-ESI-MS Patterns of Hirsutinolide-like Sesquiterpenoids Present in the Elephantopus mollis Kunth Extract and Chemophenetic Significance of Its Chemical Constituents

et al. 2021

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A total of nine sesquiterpenoid lactones together with phenolic compounds and other terpenes were identified from the crude methanol extract of Elephantopus mollis Kunth. Compounds were isolated using different chromatographic techniques and their structures were determined by NMR and IR spectroscopy as well as mass spectrometry. The structures of some detected compounds were assigned based on LC-ToF-ESI-MS screening of main fractions/subfractions from flash chromatography and comparison with isolated analogues as standards. The findings revealed not only the in-source loss of water as the base peak in hirsutinolides but also the in-source loss of corresponding alcohol when the oxygen at position 1 is alkylated. The present study also draws up a complement of data with respect to hirsutinolide-like sesquiterpene lactones whose LC-MS characteristics are not available in the literature. The chemophenetic significance is also discussed. Some of the isolated compounds were reported for the first time to be found in the species, the genus as well as the plant family. The medium-polar fractions of the crude extract, also containing the larger amount of sesquiterpenoid lactones, exhibited activity both against a cancer cell line and bacterial strains. Isolated lactones were also active against the cancer cell line, while the chlorogenic derivatives also valuable in Elephantopus genus showed potent radical scavenging activity. This is the first report of cytotoxic and antibacterial activities of our samples against the tested strains and cell line. The present study follows the ongoing research project dealing with the characterization of taxa with antibacterial and antiparasitic activities from Cameroonian pharmacopeia.

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Sesquiterpene lactones from Elephantopus mollis and their anti-inflammatory activities

Cited by 29 publications

References 12 publications

Eupalinolide J induces apoptosis, cell cycle arrest, mitochondrial membrane potential disruption and DNA damage in human prostate cancer cells

Eupalinolide J induces apoptosis, cell cycle arrest, mitochondrial membrane potential disruption and DNA damage in human prostate cancer cells

Maturation, processing and seed storage of Elephantopus mollis Kunth Maturação, processamento e armazenamento de sementes de Elaphantopus mollis Kunth.

LC-ToF-ESI-MS Patterns of Hirsutinolide-like Sesquiterpenoids Present in the Elephantopus mollis Kunth Extract and Chemophenetic Significance of Its Chemical Constituents

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