Sesquiterpene lactones from Centaurea tougourensis

Nacer, A.; Merza, Joumaa; Kabouche, Zahia; Rhouati, Salah; Boustié, Joël; Richomme, Pascal

doi:10.1016/j.bse.2011.08.013

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…Several research studies highlighted the important beneficial health effects of various wild species that constitute common ingredients of the so called Mediterranean diet [5,6]. These effects are mostly associated with their high content in phytochemicals such as flavanones [7], sterols [6], phenolic acids [8][9][10], sesquiterpene lactones [11][12][13], omega-3 fatty acids [14,15] and other secondary metabolites with bioactive and antioxidant properties. The increasing demand for functional foods has put wild edible greens in the center of attention and many recent studies have highlighted the potential of commercial exploitation of wild plants that may diversify modern diets and increase throughout the year the availability of such products [9,[16][17][18][19][20].…”

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confidence: 99%

Wild and Cultivated Centaurea raphanina subsp. mixta: A Valuable Source of Bioactive Compounds

et al. 2020

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Centaurea raphanina subsp. mixta (DC.) Runemark is a wild edible species endemic to Greece. This study evaluated the chemical composition and bioactive properties of wild and cultivated C. raphanina subsp. mixta plants. Wild plants had higher nutritional value than cultivated ones, whereas cultivated plants contained more tocopherols. Glucose and sucrose were higher in cultivated plants and trehalose in wild ones. Oxalic and total organic acids were detected in higher amounts in cultivated samples. The main fatty acids were α-linolenic, linoleic and palmitic acid, while wild plants were richer in polyunsaturated fatty acids. Two pinocembrin derivatives were the main phenolic compounds being detected in higher amounts in wild plants. Regarding the antioxidant activity, wild and cultivated plants were more effective in the oxidative haemolysis (OxHLIA) and thiobarbituric acid reactive substances (TBARS) assays, respectively. Moreover, both extracts showed moderate cytotoxicity in non-tumor cell lines (PLP2), while cultivated plants were more effective against cervical carcinoma (HeLa), breast carcinoma (MCF-7) and non-small lung cancer (NCI-H460) cell lines. Finally, wild plants showed higher antimicrobial activity than cultivated plants against specific pathogens. In conclusion, the cultivation of C. raphanina subsp. mixta showed promising results in terms of tocopherols content and antiproliferative effects, however further research is needed to decrease oxalic acid content.

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Section: Introductionmentioning

confidence: 99%

Wild and Cultivated Centaurea raphanina subsp. mixta: A Valuable Source of Bioactive Compounds

et al. 2020

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“…[43] C. athoa and C. diffusa of group III have eudesmane and elemene compounds, [44,45] while eudesmane and germacranolides compounds characterize the Centaurea species belonging to Group IV. [46][47][48][49]…”

Section: Chemosystematic Significance Of Genus Centaureamentioning

confidence: 99%

Cytotoxic and chemotaxonomic study of isolated metabolites from Centaurea aegyptiaca

Mohamed

Elshamy

Abd‐ElGawad

et al. 2020

J Chinese Chemical Soc

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The aerial parts of Centaureaa egyptiaca afforded 10 secondary metabolites including four sesquiterpene lactones; chlorohyssopifolin A (centaurepensin) (1), rediolpidetriol (2), linichlorinA (3), and sinaicin (4), one monoterpene; loliolid (5), one phenolic: tyrosol (6), three lignans; arctigenin (7), matairesinol (8), and pinoresinol (9), and one steroid; ergosta‐5,22‐dien‐3‐ol (10). The cluster analysis of 32 Centaurea species revealed that C. aegyptiaca is closely related to C. repens and C. solstitialise. The isolated compounds (1–10) were screened against CCRF‐CEM‐leukemia, MDA‐MB‐231‐pcDNA3 breast cancer, and HCT116 (p53+/+) colon carcinoma cell lines. Compounds1 and 2 were the most potent compounds against both leukemia and breast carcinoma cell lines.

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Composition and Antibacterial Activity of the Essential Oil of Cotula anthemoides

et al. 2014

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Sesquiterpene lactones from Centaurea tougourensis

Cited by 7 publications

References 27 publications

Wild and Cultivated Centaurea raphanina subsp. mixta: A Valuable Source of Bioactive Compounds

Wild and Cultivated Centaurea raphanina subsp. mixta: A Valuable Source of Bioactive Compounds

Cytotoxic and chemotaxonomic study of isolated metabolites from Centaurea aegyptiaca

Composition and Antibacterial Activity of the Essential Oil of Cotula anthemoides

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