Sesquiterpene lactones from Ajania fruticulosa

Wang, W.Z.; Tan, Renxiang; Yao, Yao; Wang, Q.; Jiang, Fan

doi:10.1016/s0031-9422(00)90410-2

Cited by 29 publications

(14 citation statements)

References 10 publications

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“…The plant has been used to treat appendicitis, tuberculosis, and emphysema in Chinese folk medicine . The literatures have shown that the main secondary metabolism of the plant included sesquiterpenes, flavonoids, sesquiterpene lactone, and phenolics . In this paper, we investigated the insecticidal activities of the essential oil, and the compounds from A .…”

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confidence: 99%

Chemical Constituents and Insecticidal Activities ofAjania fruticulosaEssential Oil

Liang

Guo

You

et al. 2016

Chemistry & Biodiversity

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The insecticidal activity and chemical constituents of the essential oil from Ajania fruticulosa were investigated. Twelve constituents representing 91.0% of the essential oil were identified, and the main constituents were 1,8-cineole (41.40%), (+)-camphor (32.10%), and myrtenol (8.15%). The essential oil exhibited contact toxicity against Tribolium castaneum and Liposcelis bostrychophila adults with LD50 values of 105.67 μg/adult and 89.85 μg/cm(2) , respectively. The essential oil also showed fumigant toxicity against two species of insect with LC50 values of 11.52 and 0.65 mg/l, respectively. 1,8-Cineole exhibited excellent fumigant toxicity (LC50 = 5.47 mg/l) against T. castaneum. (+)-Camphor showed obvious fumigant toxicity (LC50 = 0.43 mg/l) against L. bostrychophila. Myrtenol showed contact toxicity (LD50 = 29.40 μg/cm(2) ) and fumigant toxicity (LC50 = 0.50 mg/l) against L. bostrychophila. 1,8-Cineole and (+)-camphor showed strong insecticidal activity to some important insects, and they are main constituents of A. fruticulosa essential oil. The two compounds may be related to insecticidal activity of A. fruticulosa essential oil against T. castaneum and L. bostrychophila.

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Section: Introductionmentioning

confidence: 99%

Chemical Constituents and Insecticidal Activities ofAjania fruticulosaEssential Oil

Liang

Guo

You

et al. 2016

Chemistry & Biodiversity

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“…Poljak (Asteraceae), which grows mainly in the northwestern part of the People's Republic of China, has been used as a folk medicine for the treatment of appendicitis, tuberculosis, and emphysema. Previous phytochemical investigations of this species have demonstrated that it contains sesquiterpenes and phenolic compounds. , …”

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New Guaianolides and Xanthine Oxidase Inhibitory Flavonols from Ajania fruticulosa

Meng

Chen

et al. 1999

J. Nat. Prod.

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Two new guaianolides (1 and 2) were isolated from the aerial parts of Ajania fruticulosa along with a triterpene (alpha-amyrin), two plant sterols (beta-sitosterol and daucosterol), four flavonols [santin (3), axillarin (4), centaureidin, and 5,7,4'-trihydroxy-3, 3'-dimethoxyflavone], and five sesquiterpenes [ketoplenolide B, 9beta-hydroxyeudesma-4,11(13)-dien-12-oic acid, 9beta-acetoxyeudesma-4,11(13)-dien-12-oic acid, 1alpha,4alpha, 10alpha-trihydroxy-9alpha-angeloyloxyguaia-2,11(13)-dien-12, 6alpha-olide, and 3beta,4alpha-dihydroxyguaia-11(13),10(14)-dien-12, 6alpha-olide]. The structures of the new guaianolides were established as 1alpha-hydroperoxy-4beta,8alpha,10alpha, 13-tetrahydroxyguaia-2-en-12,6alpha-olide (1) and 1alpha-hydroperoxy-4alpha, 10alpha-dihydroxy-9alpha-angeloyloxyguaia-2,11(13)-dien-12, 6alpha-olide (2), respectively. Xanthine oxidase assays of all isolates revealed that santin (3) and axillarin (4) inhibited the enzyme with IC(50) values of 36.5 and 36.0 &mgr;M (that of allopurinol used as a positive control in the study was 24.2 &mgr;M), respectively.

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“…Preparative TLC (silica gel) of the oil with CHCI3 yielded kansuiphorin C (4, R 0.37, 155mg, [a]6: -5.1° in CHCI3) and kansuiphorin D (7) (5, Rf 0.35, 123 mg, [aI6: -58.3°in CHCI3). F-4 (petroleum/acetone, 25:1, 1750-3000 ml) eluted with petroleum/acetone (5: 1) yielded /3sitosterol (13) (6,,230mg,. F-5 (petroleum/acetone, 15: 1, 1200-2540 ml) eluted with CHCI3/MeOH gradient gave fractions 5/1 (100-340 ml), 5/2 (190-480m1), and 5/3 (460-53Oml).…”

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confidence: 99%