Sesquiterpene lactones and other constituents of Centaurea diffusa

Antibacterial and Cytotoxic Activities of the Sesquiterpene Lactones Cnicin and Onopordopicrin

“…near Estacion Paul Groussac, Road M, km 856, Santa Fe, Argentina. Voucher specimens (#2487 and #2487, respectively) were deposited in the herbarium of the Instituto de Botanica del Nordeste, Corrientes, Argentina [6,7]. Both plants were processed and extrated with chloroform as published [6,7].…”

“…Isolation and preparation of cnicin and onopordopicrin: Cnicin and onopordopicrin were isolated from the chloroform extract of the aerial parts of C. diffusa (CDC) and C. tweediei (CTC), respectively [6,7]. Antibacterial activity: The disk diffusion agar assay was used to determine the antibacterial activity of extracts and purified lactones.…”

“…In contrast, several species are weeds with significant economical importance in cattle farming [3]. Most of the compounds isolated from the genus Centaurea are terpenoids [4] and mainly sesquiterpene lactones [5][6][7][8][9][10][11].…”

Bio-guided identification of an anti-inflammatory guaianolide fromCentaurea ainetensis

“…Extensive chemical investigations of Centaurea species led to the isolation and identification of various types of compounds, including alkaloids (Sarker et al, 2001), lignans (Aslan & Oksuz, 1999;Kumarasamy et al, 2003), acetylenes, flavonoids (Akkal et al, , 1999(Akkal et al, , 2003Aslan & Oksuz, 1999;de Almeida et al, 1998;Flamini et al, 2001Flamini et al, , 2002, and sesquiterpene lactones (Aslan & Oksuz, 1999;Bruno et al, 2002;Chaves & De Oliviera, 2003;Fortuna et al, 2001Fortuna et al, , 2002Helal et al, 1997;Medjroubi et al, 1997Medjroubi et al, , 1998Oksuz et al, 1994;Skaltsa et al, 2000;Vajs et al, 1999;Youssef, 1998). It has been reported that the most characteristic constituents of the genus Centaurea are sesquiterpene lactones, which are classified into guaianolides, the most abundant in this genus, followed by germacranolides, elemenolides, and finally eudesmanolides (Skaltsa et al, 2000).…”

Essential Oil Composition ofCentaurea pullataL.

“…However, different classes of natural products have been isolated from these species, including flavonoids (13), sesquiterpenes (14), triterpenoids (15), alkaloids (16) and lignans (17). Sesquiterpenes lactones have a wide occurrence in this genus (18)(19)(20)(21). In previous investigations, C. pullata has been shown to contain various phenolic compounds, sesquiterpene lactones and flavonoids (22)(23)(24).…”