Sesquiterpene Lactones and Other Constituents of Vernonia mollissima and Vernonia squamulosa

Antileishmanial sesquiterpene lactones from Pseudelephantopus spicatus, a traditional remedy from the Chayahuita Amerindians (Peru). Part III

“…1). This compound has been described before in the literature in other species, and our analytical data are in accordance with those reported therein (Catalán et al, 1986;Bardón et al, 1993;Valdés et al, 1998).…”

“…Two acetate groups with protons at ı 2.09 and 2.10 ppm are linked to carbons C-13 and C-8, respectively, as demonstrated by the 4 J couplings observed in the HMBC experiment between protons H-17 and carbon C-13 and protons H-19 and carbon C-8. It turned out that this compound was the 8,13-diacetyl-piptocarphol (1) that has been described before in the literature (Catalán et al, 1986;Bardón et al, 1988Bardón et al, , 1993 Fig. 1).…”

“…H. Rob., Chrysolaena verbascifolia, Lepidaploa remotiflora and Vernonia scorpioides (Catalán et al, 1986;Bardón et al, 1993;Borkosky et al, 1996;Valdés et al, 1998;Buskuhl et al, 2010). Extensive bibliographical searches revealed that none of those species seemed to be used as antileishmanials.…”

Chemical Constituents, Antiproliferative and Antioxidant Activities of Vernonanthura nudiflora (Less.) H. Rob. Aerial Parts

“…49 The triterpenes lupeol (1) and β-amyrin (3) and the flavones velutin (10), apigenin (11) and chrysoeriol (12) were previously isolated from V. nudiflora. 23 Despites the sesquiterpene lactones piptocarphin A (6), B (7) and D (8) already described in other Vernonanthura and Vernonia species, [50][51][52][53] this is the first report of piptocarphins in V. nudiflora. Also, this is the first description of the presence of 2, 4-5 and 13-17 in V. nudiflora aerial parts besides the report of the new hirsutinolide sesquiterpene lactone 9.…”

“…Many studies have demonstrated that polyphenols, including flavonoids, can act at different points during the carcinogenesis process, through several mechanisms of action, alone or in a synergistic way. 59,60 The dichloromethane fraction (DC) inhibited all human tumor and non-tumor cell lines tested with GI 50 and TGI values ranging from 0.27 to 3.98 μg mL -1 and 1.60 to 29.37 μg mL -1 , respectively, being selective for 14).…”