Sesquiterpene lactones and other bioactive constituents from Schkuhria pinnata var. wislizeni (Asteraceae)

León, Alejandra; Reyes, Blanca; Delgado, Gerzon E.

doi:10.1055/s-0028-1084372

Cited by 1 publication

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“…The powdered leaf of S. pinnata has been used as a remedy for malaria, influenza, and colds [9]. Also, S. pinnata has been used as an insecticide, particularly to kill fleas [11]. Extracts from S. pinnata were shown to inhibit Brucella abortus in vitro [10], and have yielded several sesquiterpene lactones and the phenyl propanoids [11].…”

Section: Resultsmentioning

confidence: 99%

“…Also, S. pinnata has been used as an insecticide, particularly to kill fleas [11]. Extracts from S. pinnata were shown to inhibit Brucella abortus in vitro [10], and have yielded several sesquiterpene lactones and the phenyl propanoids [11]. Both schkuhrin I (1) and II (2) have been isolated from the same species and other Schkuhria species, but their antiprotozoal activities have not been reported previously.…”

Section: Resultsmentioning

confidence: 99%

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Antiprotozoal Screening of 60 South African Plants, and the Identification of the Antitrypanosomal Germacranolides Schkuhrin I and II

et al. 2013

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Two hundred and seven extracts were prepared from sixty plants from South Africa and screened for in vitro activity against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. For the 21 extracts which inhibited the growth of one or more parasites with more than 95 % at 10 µg/mL, the IC50 values against all four protozoal parasites and cytotoxic IC50 values against L6 myoblasts were determined. Amongst the most notable results are the activities of Psoralea pinnata (IC50 of 0.15 µg/mL), Schkuhria pinnata (2.04 µg/mL), and Vernonia mespilifolia (1.01 µg/mL) against Trypansoma brucei rhodesiense. HPLC-based activity profiling was used to identify the active constituents in the extracts, and the germacranolide sesquiterpene lactones schkuhrin I and II from S. pinnata, and cynaropicrin from V. mespilifolia were identified, with IC50 values of 0.9, 1.5, and 0.23 µM, respectively.

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Section: Resultsmentioning

confidence: 99%