Sesquiterpene Lactones, Acyl Phenyl Propanoids and Other Constituents from Schkuhria pinnata var. wislizeni. Antioxidant Evaluation

Abstract

Chemical investigation of aerial parts of Schkuhria pinnata var wislizeni (Asteraceae) allowed the characterization of the sesquiterpene lactones 1, 2 and 5, the flavonoids 3 and 4, and the acyl phenyl propanoids 10 and 11. Structure 2, named dischkuhriolin, was confirmed as a Diels Alder adduct of 1 as dienophile and a guaianolide as diene. Spectroscopic analysis of 5 and its diacetyl derivative allowed the structural correction of compounds previously reported from Schkuhria. 2, 10 and 11 are new natural compounds. Biological assays indicated that the mixture 10 + 11 showed antioxidant activity expressed as inhibition of AAPH-induced damage in rat pancreatic homogenate.

Hypoglycemic and Antioxidant Effects of Subcoriacin in Normal and Streptozotocin-induced Diabetic Rats

“…We have shown earlier that STZ produced oxidative stress and depletion of antioxidant systems in the rat pancreas [10,11]. As a continuation of our search for secondary metabolites with hypoglycemic and antioxidant activities [10,12], the present report examines the hypoglycemic activity as well as the protective effectiveness of 1 in the pancreas from both normal and STZ-treated rats.…”

“…In this context, recent attention has been focused on the analysis of the protective antioxidant biochemical function of several plants [8] as well as some natural products [9][10][11][12] which displayed not only radical scavenger capacity, but also improved the antioxidant enzymatic system. Indeed, the protective effects of terpenes, flavonoids and polyphenols on several models of diabetes mellitus have been demonstrated.…”

Transformations of Some Sesquiterpene Lactones by Filamentous Fungi and Cytotoxic Evaluations

“…Thus, with the aim of exploring the bioreactivity and bioactivity of several SLs, we carried out the transformations of arglanin ( 1 ), 11,13‐dehydroeriolin ( 2 ), budlein B ( 3 ), ludovicin A ( 4 ), santamarin ( 5 ),, epoxysantamarin ( 6 ), parthenolide ( 7 ), sphaerocephalin ( 8 ) and deacetylconfertiflorin ( 9 ) by eight filamentous fungi previously used by our group . The biotransformations afforded the products 10 – 17 , which were previously characterized as natural products.…”