Sesquiterpene coumarins from seeds of Ferula sinkiangensis

Li, Guangzhi; Li, Xiaojin; Cao, Li; Zhang, Lijing; Shen, Liangang; Zhu, Jian; Wang, Junchi; Si, Jianmin

doi:10.1016/j.fitote.2015.03.022

Cited by 47 publications

(32 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…persica and F. halophila, as well as the hexane extract of F. elaeochytris, were assigned to be more active than methanolic extracts of the plants [36][37][38]. In addition, the acetylcholinesterase inhibitory activities of coumarin derivatives from F. gummosa and F. asafoetida species were determined, previously [30][31][32][33][34][35][36][37][38][39][40][41]. In the current study, the chloroform extracts of F. caspica and F. halophila that could be expected to contain some coumarin derivatives weren't found to be as active as methanol extracts of the plants compared to standard donepezil.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Kahraman¹,

Baysal²,

Cankaya³

et al. 2019

jrp

View full text Add to dashboard Cite

The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Peşmen. Antioxidant capacities and total phenolic contents of the plants' extracts were tested by DPPH radical scavenging assay and Folin Ciocalteu assay, respectively. Acetylcholinesterase inhibitory activities of the extracts were investigated with the aim of indicating whether there was a correlation with their antioxidant capacities. Different quinic acid and flavonoid derivatives which may be responsible for the activities of the extracts were detected using LC-MS screening in the methanol extracts. The methanol extract from the aerial parts of F. caspica was found to show most antioxidant capacity and acetylcholinesterase inhibitory activity.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Especially, sesquiterpene and coumarin derivatives were isolated from apolar extracts of Ferula species [29][30][31][32]. Studies on the polar metabolites are unfortunately limited.…”

Section: Lc-ms Analysis Of Phenolic Compoundsmentioning

confidence: 99%

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Kahraman¹,

Baysal²,

Cankaya³

et al. 2019

jrp

View full text Add to dashboard Cite

show abstract

“…Cytotoxic testing was performed as the following previously described protocols [5,6].The cytotoxicity of the two new compounds were assessed using the MTT method against AGS, MGC-803 and Hela human cancer cell lines. AGS cells were cultured in Ham's F12 medium supplemented with 10% fetal bovine serum, while MGC-803 and Hela cells were cultured in DMEM medium.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Two New Coumarins from the Leaves of Phellodendronamurense.

Zhang¹,

Li²,

Dai³

et al. 2017

SOJPPS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ferula , a kind of traditional herbal medicine used for many centuries, exhibits multiple biological activities (Nazari & Iranshahi, ). Ferula is a genus of flowering plants and contains over 150 species, one of which is Ferula sinkiangensis (Li et al, ). In our previous study, we investigated the properties of Ferula sinkiangensis extract using bioactivity‐guided isolation, bioassays, and multiple chromatography and spectroscopy methods (Xing et al, ).…”

Section: Introductionmentioning

confidence: 99%

Kellerin alleviates cognitive impairment in mice after ischemic stroke by multiple mechanisms

Zhang

Jiang

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

Ischemic stroke is a global disease with high disability and mortality rates. Cognitive impairment is one of the major clinical features of ischemic stroke, and microglia‐mediated inflammation has been shown to be an important contributor to the pathogenesis of ischemic stroke. Kellerin, extracted from Ferula sinkiangensis, was previously shown to inhibit microglial activation and exert a strong anti‐neuroinflammatory effect. However, there is no report of the potential therapeutic effect of kellerin on ischemic stroke by targeting microglial cells. In this study, we wanted to examine the effects of kellerin on ischemic stroke in the bilateral common carotid artery occlusion (BCCAO) model and the lipopolysaccharide (LPS)‐activated microglia model. We found that kellerin alleviated cognitive impairment, decreased neuronal loss, suppressed microglial activation, and transformed microglia from the pro‐inflammatory M1 phenotype to the anti‐inflammatory M2 phenotype in BCCAO mice. Moreover, in in vitro studies, we found that kellerin regulated microglial polarization and inhibited the NLRP3 and MAPK signaling pathways after LPS treatment. These findings provide a new understanding of the function of kellerin in ischemic stroke, and suggest that kellerin could be a potential therapeutic agent for the treatment of ischemic stroke.

show abstract

Sesquiterpene coumarins from seeds of Ferula sinkiangensis

Cited by 47 publications

References 5 publications

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Two New Coumarins from the Leaves of Phellodendronamurense.

Kellerin alleviates cognitive impairment in mice after ischemic stroke by multiple mechanisms

Contact Info

Product

Resources

About