Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats

Yang, Yang; Yuan, Qing; Liu, Xiaoqiang; Zhao, Ronghua; Yu, Jing; Hu, Suying; Kang, Jingqi; Zhang, Yaling; Gong, Yi; Cui, Tongtong; Zhang, Xin; Yan, Yaping

doi:10.1039/d1fo01517f

Cited by 12 publications

(9 citation statements)

References 49 publications

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“…Sesamol is extracted from sesame oil and can be used as an antioxidant in foods and medicines [ 44 ]. Several studies have revealed that sesamol protects the body from various disease conditions such as obesity, hyperlipidemia, and diabetic foot ulcer mainly through regulating lipid as well as energy metabolism and reducing inflammatory cell infiltration [ 45 – 47 ].…”

Section: Discussionmentioning

confidence: 99%

Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice

Feng

Chen

Zaeem

et al. 2022

Oxidative Medicine and Cellular Longevity

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Inflammation is one of the crucial mechanisms mediating spinal cord injury (SCI) progress. Sesamol, a component of sesame oil, has anti-inflammatory activity, but its mechanism in SCI remains unclear. We investigated if the AMPK/SIRT1/NF-κB pathway participated in anti-inflammation of sesamol in SCI. Sesamol could inhibit neuronal apoptosis, reduce neuroinflammation, enhance M2 phenotype microglial polarization, and improved motor function recovery in mice after SCI. Furthermore, sesamol increased SIRT1 protein expression and p-AMPK/AMPK ratio, while it downregulated the p-p65/p65 ratio, indicating that sesamol treatment upregulated the AMPK/SIRT1 pathway and inhibited NF-κB activation. However, these effects were blocked by compound C which is a specific AMPK inhibitor. Together, the study suggests that sesamol is a potential drug for antineuroinflammation and improving locomotor functional recovery through regulation of the AMPK/SIRT1/NF-κB pathway in SCI.

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Section: Discussionmentioning

confidence: 99%

Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice

Feng

Chen

Zaeem

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…The combined effect of sesamol as an add-on drug along with the available therapy to control hyperlipidemia and ischemic heart diseases [51]. Sesamol has been documented to posses Sesamol with crocin, an approach that could not only abolish the toxic effects of sesamol on platelets, but also enhance the quality of treatment due to their synergistic action, on the lines of combinatorial drug therapy [52].…”

Section: Combination Therapy Of Sesamol With Other Drugsmentioning

confidence: 99%

An Insight Into Sesamol: Pharmacological Activities, and Future Research Prospects

Khatoon¹

2022

IJSREM

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In the current review, most of the pharmacological effects (in vivo and in vitro) of sesamol are summarized as, hepatoprotective activity, anti-microbial, neuroprotective, cardio protective, anti-inflammatory, anticonvulsant, anti-anxiolytic, wound healing, cosmetic (skin whitening), anti-cancer, antioxidant, and other biological effects. Here compile the proposed mechanism behind these pharmacological effects. The present work summarizes the most interesting in vitro and in vivo studies on the biological effects of sesamol. Another Sesamol work summarizes data available from Pub med and Scopus databases. Keyword: Medicinal uses of sesamol, Pharmacological properties of Sesamol, Bioavailability, Combination Therapy of Sesamol with Other Drugs, Doses, Metabolism and Excretion of Sesamol, The Important Role of Sesamol in the Treatment of osteoporosis Disease

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“…Cholesterol-rich diets induce systemic inflammation . High fat and cholesterol diets promote the development of atherosclerosis and steatohepatitis. , Many studies reported that high fat and cholesterol diets (HFCDs) disturbed the gut microbiome in various ways, such as reducing the alpha diversity of bacteria, decreasing the Firmicutes to Bacteroidota ratio, suppressing some probiotics (e.g., Akkermansia , Bifidobacterium , and Lactobacillus , ), or irritating the potentially harmful bacterial (e.g., Desulfovibrio , Desulfovibrionaceae , Oscillibacter , Alistipes , and Erysipelotrichaceae ,− ).…”

Section: Introductionmentioning

confidence: 99%

Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism

Yan

Chen

Zhu

et al. 2022

J. Agric. Food Chem.

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Hyperlipidemia is intricately associated with the dysregulation of gut microbiota and host metabolomes. This study explored the antihyperlipidemic function of oryzanol and investigated whether the function of oryzanol affected the gut microbiome and its related metabolites. Hamsters were fed a standard diet (Control) and a high fat and cholesterol (HFCD) diet with or without oryzanol, separately. Our results showed that oryzanol significantly decreased HFCD-induced fat accumulation, serum total cholesterol, low-density lipoprotein cholesterol (LDL-c), LDL-c/HDL-c ratio, triglyceride, and liver steatohepatitis, attenuated HFCD-induced gut microbiota alterations, and altered amino acid concentrations in feces and the liver. We investigated the role of the gut microbiota in the observed beneficial effects; the protective effects of oryzanol were partly diminished by suppressing the gut bacteria of hamsters after using antibiotics. A fecal microbiota transplantation experiment was carried out by transplanting the feces from HFCD group hamsters or hamsters given oryzanol supplementation (as a donor hamster). Our results showed that administering the fecal liquid from oryzanol-treated hamsters attenuated HFCD-induced hyperlipidemia, significantly decreased the abundance of norank_f__Erysipelotrichaceae, norank_f__Eubacteriaceae, and norank_f__Oscillospiraceae and the concentration of tyrosine. These outcomes are significantly positively correlated with serum lipid concentration. This study illustrated that gut microbiota is the target of oryzanol in the antihyperlipidemic effect.

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Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats

Abstract: Sesamol, a major ingredient in sesame seeds (sesamum indicum L.) and its oil, is considering as a powerful functional food ingredient. However, few researches investigated its effects on high-fat, high...

Cited by 12 publications

References 49 publications

Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice

Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice

An Insight Into Sesamol: Pharmacological Activities, and Future Research Prospects

Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism

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