Sesamin suppresses LPS-induced microglial activation via regulation of TLR4 expression

Udomruk, Sasimol; Kaewmool, Chayanut; Pothacharoen, Peraphan; Phitak, Thanyaluck; Kongtawelert, Prachya

doi:10.1016/j.jff.2018.08.020

Cited by 30 publications

(18 citation statements)

References 45 publications

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“…Sesamin, a major lignan from sesame seeds and oil, exhibits the neuroprotective effects in various neurodegenerative conditions. Our previous study also demonstrated that sesamin inhibited LPS-induced microglial activation and protected neuronal cell death [9]. Simultaneously, sesamin was found to improve memory and behavior in chronic mild stress-induced memory deficits [18].…”

Section: Discussionmentioning

confidence: 86%

“…Sesamin, a major lignan compound found in sesame seeds and oil, is considered to possess several bioactivities to be beneficial for human health and is widely used as a supplement, especially in Asian countries. e neuroprotective effect of sesamin was reported in various studies [7][8][9]. Our previous study also reported that sesamin inhibited microglial activation and protected neuronal cell death induced by neurotoxic factors [9].…”

Section: Introductionmentioning

confidence: 73%

“…e neuroprotective effect of sesamin was reported in various studies [7][8][9]. Our previous study also reported that sesamin inhibited microglial activation and protected neuronal cell death induced by neurotoxic factors [9]. However, its effect on neurogenesis is not well established.…”

Section: Introductionmentioning

confidence: 93%

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Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation

Udomruk

Kaewmool

Phitak

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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e promotion of neurogenesis can be a promising strategy to improve and restore neuronal function in neurodegenerative diseases. Nerve growth factor (NGF) plays a key role in neurite outgrowth and synaptic formation during brain repair stage. Nowadays, there are several studies on the developing methods to enhance the endogenous NGF activity for treatment and restore the neuronal function. In this study, the potentiating effect of sesamin, a major lignan in sesame seeds (Sesamum indicum) and oil, on NGF-induced neurogenesis and its involved mechanisms were firstly reported. Sesamin effectively enhanced the PC12 neuronlike cell differentiation and neurite length under insufficient conditions of NGF. e neuronal markers including synaptophysin and growth-associated protein-43 along with the synaptic connections were significantly increased in combination treatment between sesamin and NGF. Moreover, sesamin also increased the level of phospho-ERK1/2 and SIRT1 protein, an important regulatory protein of the neurogenesis process. e neurogenesis was blocked by the specific SIRT1 inhibitor, JGB1741, suggesting that the neuritogenic effect of sesamin was associated with SIRT1 protein modulation. Taken together, the potentiating effect of sesamin on NGF-induced neurogenesis in this finding could be used for alternative treatment in neurodegenerative diseases, including Alzheimer's disease.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 73%

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Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation

Udomruk

Kaewmool

Phitak

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…In the literature study [34] showed that wherein the BV-2 microglial cell line was used, sesamin shows dose-dependent decrease in expression of TLR4 in LPS-stimuli. Notably, at 50 µM concentration of sesamin, there is a significant decrease in the expression of TLR4.…”

Section: Neurodegenerative Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

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“…The natural products derived from plants are being evaluated for their therapeutic benefits based on the popularity of local medicinal plants. For examples, an andrographolide from the stem and leaves of Andrographis paniculata [ 11 , 12 ], sesamin from Sesamum indicum seeds [ 13 , 14 ], hesperidin from citrus fruits including sweet orange, mandarin, lemon, and lime [ 15 ], and curcumin from the rhizome of Curcuma longa [ 16 ] are found to present a variety of biological effects, therapeutic benefits, and are used in the treatment of many types of diseases, including anti-dengue virus activity [ 11 ], antiviral, antibacterial [ 12 ], anti-inflammation [ 13 , 14 ], antioxidant [ 14 ], and anticancer activities [ 15 , 16 ]. This discovery officially confirms the potential activity for the novel coronavirus treatments.…”

Section: Introductionmentioning

confidence: 99%

Molecular modelling investigation for drugs and nutraceuticals against protease of SARS-CoV-2

Kodchakorn

Poovorawan

Suwannakarn

et al. 2020

Journal of Molecular Graphics and Modelling

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The widespread problem of a 2019-novel coronavirus (SARS-CoV-2) strain outbreak in Wuhan, China has prompted a search for new drugs to protect against and treat this disease. It is necessary to immediately investigate this due to the mutation of the viral genome and there being no current protective vaccines or therapeutic drugs. Molecular modelling and molecular docking based on in silico screening strategies were employed to determine the potential activities of seven HIV protease (HIV-PR) inhibitors, two flu drugs, and eight natural compounds. The computational approach was carried out to discover the structural modes with a high binding affinity for these drugs on the homology structure of the Wuhan coronavirus protease (SARS-CoV-2 PR). From the theoretical calculations, all the drugs and natural compounds demonstrated various favorable binding affinities. An interesting finding was that the natural compounds tested had a higher potential binding activity with the pocket sites of SARS-CoV-2 PR compared to the groups of HIV-PR inhibitors. The binding modes of each complex illustrated between the drugs and compounds interacted with the functional group of amino acids in the binding pocket via hydrophilic, hydrophobic, and hydrogen bond interactions using the molecular dynamics simulation technique. This result supports the idea that existing protease inhibitors and natural compounds could be used to treat the new coronavirus. This report sought to provide fundamental knowledge as preliminary experimental data to propose an existing nutraceutical material against viral infection. Collectively, it is suggested that molecular modelling and molecular docking are suitable tools to search and screen for new drugs and natural compounds that can be used as future treatments for viral diseases.

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Sesamin suppresses LPS-induced microglial activation via regulation of TLR4 expression

Cited by 30 publications

References 45 publications

Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation

Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Molecular modelling investigation for drugs and nutraceuticals against protease of SARS-CoV-2

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