Sesamin improves endothelial dysfunction in renovascular hypertensive rats fed with a high-fat, high-sucrose diet

Kong, Xiang; Jie-ren, Yang; Guo, Liqun; Xiong, Ying; Wu, Xiangqi; Huang, Kai; Zhou, Yong

doi:10.1016/j.ejphar.2009.08.023

Cited by 38 publications

(52 citation statements)

References 35 publications

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“…Here our observations showed that SO decreases the 6-OHDA induced neurotoxicity and restores of striatal dopamine and its metabolites in mice brain by enhancing and activating antioxidant defense mechanisms which indicates that SO may act as an intracellular ROS scavenger. The earlier reports suggest that the antioxidant compounds present in SO such as sesamin, sesamol and sesamolin inhibit excess production of ROS in various human diseases like hypertension, endothelial dysfunction and hepatic disorder and also inhibit 20-Hydroxyeicosatetraenoic acid synthesis which is involved in renal dysfunction [17,36].…”

Section: Discussionmentioning

confidence: 99%

“…SO in comparison to other dietary oils such as groundnut, canola and sunflower oil depicted better protection against increased blood pressure, hyperlipidemea and LPO by increasing enzymatic and non-enzymatic antioxidants [14]. Sesamin, sesamolin and tocopherols are powerful antioxidants in SO, and have been reported to possess a broad spectrum of pharmacological effects including neuroprotective, anti-inflammatory, antihypertensive and antimutagenic [15][16][17]. Sesamin and sesamolin have been shown inhibitory effect on LPS-activated p38 mitogen activated protein kinase (MAPK) and nuclear factor kB (NF-kB) activation in microglial cells [18].…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective Effect of Sesame Seed Oil in 6-Hydroxydopamine Induced Neurotoxicity in Mice Model: Cellular, Biochemical and Neurochemical Evidence

et al. 2011

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Natural antioxidants have shown a remarkable reduction in oxidative stress due to excess formation of reactive oxygen species by enhancing antioxidant mechanism in the neurodegenerative disorders. Sesame seed oil (SO) is one of the most important edible oil in India as well as in Asian countries and has potent antioxidant properties thus the present study evaluated the neuroprotective effect of SO by using 6-Hydroxydopamine (6-OHDA)-induced Parkinson's disease model in mice. The mice were fed an SO mix diet for 15 days and then 6-OHDA was injected into the right striatum of mice brain. Three weeks after 6-OHDA infusion, mice were sacrificed and the striatum was removed. The neuroprotective role of SO on the activities of antioxidant and non-antioxidant enzymes such as glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), catalase (CAT) and content of glutathione (GSH) and thiobarbituric acid reactive substance (TBARS) were studied in the striatum. The activities of all the above-mentioned enzymes decreased significantly in 6-OHDA group (Lesioned) when compared with Sham. The pretreatment of SO on antioxidant mechanism and dopamine level in the brain had shown some significant improvement in Lesion+SO (L+SO) group when compared with Lesioned group. However, NADPH oxidase subunit, Nox2 and inflammatory stimulator Cox2 expression was increased as well as antioxidant MnSOD level was decreased in Lesioned group while SO showed the inhibitory effect on the activation of Nox2 and Cox2 and restored MnSOD expression in L+SO group. Increased tyrosine hydroxylase (TH) expression in substantia nigra as well as dopamine and its metabolite DOPAC level in L+SO group also support our findings that SO may inhibit activation of NADPH oxidase dependent inflammatory mechanism due to 6-OHDA induced neurotoxicity in mice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Sesame Seed Oil in 6-Hydroxydopamine Induced Neurotoxicity in Mice Model: Cellular, Biochemical and Neurochemical Evidence

et al. 2011

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“…As mentioned in our previous study, 28 the aortic ring was suspended by a pair of stainless steel hooks in a water-jacketed organ bath containing 10 ml Krebs solution at 37°C, and continuously bubbled with carbogen. Changes in isometric tension were detected by a JZ101 force transducer (Xinhang Electric Apparatus, China).…”

Section: Vascular Reactivity Studiesmentioning

confidence: 99%

“…As described in our previous study, 18,28 equal amounts of protein (40 μg protein/lane) were separated by electrophoresis on a sodium dodecyl sulfate polyacrylamide gel. The proteins were transferred electrophoretically to nitrocellulose membranes.…”

Section: Western Blot Analysismentioning

confidence: 99%

“…Systolic blood pressure (SBP) was measured on a monthly basis in conscious rats using the tail-cuff method (ALC-NIBP, Shanghai, China) as described in our previous studies. 19,28 The rats were placed in metabolic cages to collect 24-hour urine at the 16th week. At the end of the study, the rats were fasted overnight and anesthetized by an intraperitoneal injection of sodium pentobarbital.…”

Section: Experimental Designmentioning

confidence: 99%

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Pioglitazone enhances the blood pressure-lowering effect of losartan via synergistic attenuation of angiotensin II-induced vasoconstriction

Kong

Qin

et al. 2013

J Renin Angiotensin Aldosterone Syst

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Introduction: This study was designed to investigate the underlying mechanisms of synergistic antihypertensive effect produced by combination therapy of losartan and pioglitazone in metabolic syndrome (MS) rats. Materials and methods: An MS model was induced by feeding rats a high-fat, high-sodium diet and 20% sucrose solution. Losartan (20 mg/kg/day), pioglitazone (10 mg/kg/day), and their combination were orally administered for eight consecutive weeks. Systolic blood pressure (SBP) and mean arterial pressure (MAP) were measured using the tail-cuff method and carotid arterial catheterization, respectively. The aortas were isolated and in vitro vascular reactivity studies were performed. The protein expression of angiotensin type 1 receptor (AT 1 ), endothelial nitric oxide synthase (eNOS), phosphorylated eNOS and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit p47 phox , level of nitrotyrosine as well as activity of eNOS and NADPH oxidase in aortas of MS rats were detected. Results: After eight weeks of treatment, the SBP and MAP in the losartan (115 ± 5 and 106 ± 6 mmHg), pioglitazone (130 ± 6 and 118 ± 6 mmHg), and combination therapy (105 ± 6 and 98 ± 5 mmHg) groups were lower than those in the model group (150 ± 8 and 136 ± 9 mmHg). Combination therapy of losartan and pioglitazone reduced BP more than either monotherapy, and showed additive effects on improving endothelial dysfunction and abolishing the increased vascular responsiveness to angiotensin II. These synergistic effects were associated with further reductions in protein expression of p47 phox and AT 1 , NADPH oxidase activity, and nitrotyrosine level. Conclusions: Our data indicate that combined treatment exerts more beneficial effects on lowering BP and improving vascular lesions.

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Enantiomere Naturstoffe: Vorkommen und Biogenese

et al. 2012

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In der Natur werden chirale Substanzen meist in enantiomerenreiner Form synthetisiert – manchmal entstehen aber auch beide Enantiomere. Solche enantiomeren Naturstoffe können von einer Art oder von verschiedenen Gattungen und/oder Arten gebildet werden. Intensive Forschungen wurden über viele Jahre durchgeführt, um die Biogenese natürlich vorkommender Enantiomere zu verstehen, doch viele faszinierende Rätsel und stereochemische Anomalien sind nach wie vor ungelöst.

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Sesamin improves endothelial dysfunction in renovascular hypertensive rats fed with a high-fat, high-sucrose diet

Cited by 38 publications

References 35 publications

Neuroprotective Effect of Sesame Seed Oil in 6-Hydroxydopamine Induced Neurotoxicity in Mice Model: Cellular, Biochemical and Neurochemical Evidence

Neuroprotective Effect of Sesame Seed Oil in 6-Hydroxydopamine Induced Neurotoxicity in Mice Model: Cellular, Biochemical and Neurochemical Evidence

Pioglitazone enhances the blood pressure-lowering effect of losartan via synergistic attenuation of angiotensin II-induced vasoconstriction

Enantiomere Naturstoffe: Vorkommen und Biogenese

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