Sesamin imparts neuroprotection against intrastriatal 6-hydroxydopamine toxicity by inhibition of astroglial activation, apoptosis, and oxidative stress

Baluchnejadmojarad, Tourandokht; Mansouri, Monireh; Ghalami, Jamileh; Mokhtari, Zahra; Roghani, Mehrdad

doi:10.1016/j.biopha.2017.01.123

Cited by 49 publications

(22 citation statements)

References 57 publications

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“…Sesamin at dosage 20 ppm has shown to suppress 6-hydroxydopamine (6-OHDA) that induces Parkinson's disease in rats [43] via decrease in inflammatory mediator levels in the brain. Sesamin has the capability to alleviate astrogliosis based on the lowering effect of glial fibrillary acidic protein (GFAP) immunoreactivity.…”

Section: Neurodegenerative Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

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Section: Neurodegenerative Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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“…Other reports also demonstrated that some of these constituents (sesamol, sesamolin, sesamin, and sesaminol) inhibit the proinflammatory cytokines such as TNF‐α, IL‐1β, IL‐6, and NF‐kB either in vivo rat (Bournival, Plouffe, Renaud, Provencher, & Martinoli, ; Chen et al, ; Hemshekhar et al, ; Hsu, Chu, Chandrasekaran, & Liu, ; Jeng & Hou, ; Yashaswini et al, 2017b) or in vitro cell culture model (Bournival et al, ). Sesamol, sesamolin, and sesamin also suppress the inflammatory cascade by downregulating the expression of caspase‐3 (Baluchnejadmojarad, Mansouri, Ghalami, Mokhtari, & Roghani, ; Chopra, Tiwari, Arora, & Kuhad, ; Hsieh et al, ; Hung et al, ; Jeng & Hou, ). A recent clinical trial was reported on sesamin supplementation on cardiovascular risk factors in women with rheumatoid arthritis, and the results found that sesamin research had been conducted and evaluated by Helli, Mowla, Mohammadshahi, and Jalali (), which showed protective effect of SO (Helli et al, ).…”

Section: Resultsmentioning

confidence: 99%

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

Afroz

Zihad

Uddin

et al. 2019

Phytotherapy Research

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Traditionally, sesame oil (SO) has been used as a popular food and medicine. The review aims to summarize the antioxidant and antiinflammatory effects of SO and its identified compounds as well as further fatty acid profiling and molecular docking study to correlate the interaction of its identified constituents with cyclooxygenase-2 (COX-2). For this, a literature study was made using Google Scholar, Pubmed, and SciFinder databases. Literature study demonstrated that SO has potential antioxidant and antiinflammatory effects in various test systems, including humans, animals, and cultured cells through various pathways such as inhibition of COX, nonenzymatic defense mechanism, inhibition of proinflammatory cytokines, NF-kB or mitogenactivated protein kinase signaling, and prostaglandin synthesis pathway. Fatty acid analysis of SO using gas chromatography identified known nine fatty acids. In silico study revealed that sesamin, sesaminol, sesamolin, stigmasterol, Δ5-avenasterol, and Δ7-avenasterol (−9.6 to −10.7 kcal/mol) were the most efficient ligand for interaction and binding with COX-2. The known fatty acid also showed binding efficiency with COX-2 to some extent (−6.0 to −8.4 kcal/mol). In summary, it is evident that SO may be one of promising traditional medicines that we could use in the prevention and management of diseases associated with oxidative stress and inflammation.

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“…08 . Submit Manuscript also lowered malondialdehyde, caspase 3 activity, α-synuclein expression and ROS [130]. Another report by Kiyofuji et al, evidenced that supplementation of 10μM macelignan (a nutmeg lignan) to the mice midbrain slice cultures treated with IFN-γ and LPS showed dramatic effect on inflammation induced degeneration of dopaminergic neurons through expression of arginase-1 [131].…”

Section: Lignans With Anti-pd Effectmentioning

confidence: 92%

A Mini Review on the Protective Effect of Lignans for the Treatment of Neurodegenerative Disorders

2019

NFLS

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Nature is a rich source of numerous bioactive compounds that are categorized as secondary metabolites. Lignans are group of such compounds, generally called phytoestrogens widely present in many plants and vegetables, grains, seeds, nuts and tea. They have been used as folk medicine for the treatment of several clinical conditions like asthma, cardiovascular diseases, arthrosclerosis, colitis and many more. Structurally, lignans are characterized by two phenylpropane groups attached by a carbon bond. They have been divided in to several types on the basis of structure of their carbon skeleton, the way of cyclization and oxygen incorporation in the skeleton. Lignans from numerous plant species such as Kadsura

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Sesamin imparts neuroprotection against intrastriatal 6-hydroxydopamine toxicity by inhibition of astroglial activation, apoptosis, and oxidative stress

Cited by 49 publications

References 57 publications

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

A Mini Review on the Protective Effect of Lignans for the Treatment of Neurodegenerative Disorders

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