Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke

Ahmad, Saif; Elsherbiny, Nehal M.; Haque, Rizwanul; Khan, M. Badruzzaman; Ishrat, Tauheed; Shah, Zahoor A.; Khan, Mohammad M.; Ali, Mehboob; Jamal, Arshad; Katare, Deepshikha Pande; Liou, Gregory I.; Bhatia, Kanchan

doi:10.1016/j.neuro.2014.10.002

Cited by 84 publications

(57 citation statements)

References 59 publications

(70 reference statements)

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“…Shutting off the flow of cerebral blood to thrombi results to ischemic brain stroke due to loss of oxygen and energy supply to crucial tissues of the brain. In middle cerebral artery occlusion (MCAO)-treated mice [42], sesamin (30 ppm) mitigates brain injury by suppressing the production of inflammatory mediators. Interestingly, sesamin reduces the expression levels of p-ERK1/2 together with p-p38 of ischemic brain tissue in MCAO-induced brain damage.…”

Section: Neurodegenerative Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

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Section: Neurodegenerative Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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“…Sesamin produces effective neuroprotection against cerebral ischemia [15]. Sesamin has been reported to rescue neuronal PC12 cells from apoptosis and death induced by the MPP+ activation of microglia cells [28], protect neuronal PC12 cells from high-glucose-induced oxidation and apoptosis [29], and protect neurons against hypoxic neuronal injury [30].…”

Section: Discussionmentioning

confidence: 99%

“…A study demonstrates that sesamin can diminish iNOS and COX-2 protein expressions and significantly restore the SOD activity and protein expression levels in the acute hepatic injury rats [46]. Furthermore, sesamin treatment also significantly reduces inflammatory and oxidative stress markers including Iba1, Nox-2, and Cox-2 [15].…”

Section: +mentioning

confidence: 98%

“…Sesamin (a typical lignan with β-linkage) and sesamolin (a compound with a phenyl group with an acetaloxygen bridge) are two major lignans in sesame seeds and oil ( Figure 1A), which are also found in several medicinal herbs, such as Acanthopanax senticosus. Sesamin is recognized to have various pharmacological effects, such as hypocholesterolemia, anti-hypertension, anti-inflammation, and protective effects against neurotoxicity, hypoxic and oxidative damage [12][13][14][15]. The neuroprotective effects of sesamin have been investigated in models of MCAO [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…Sesamin is recognized to have various pharmacological effects, such as hypocholesterolemia, anti-hypertension, anti-inflammation, and protective effects against neurotoxicity, hypoxic and oxidative damage [12][13][14][15]. The neuroprotective effects of sesamin have been investigated in models of MCAO [15,16]. However, the underlying neuroprotective mechanisms of sesamin are not well known.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neuroprotection of Sesamin against Cerebral Ischemia In-Vivo and N-Methyl-D-Aspartate-Induced Apoptosis In-Vitro

Tian¹,

Tian²

2015

Biochem Pharmacol (Los Angel)

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Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes

Wang

et al. 2023

Advanced Science

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Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is morphologically and mechanistically different from other forms of cell death, plays a vital role in the pathophysiological process of neurodegenerative diseases, and strokes. Accumulating evidence supports ferroptosis as a critical factor of neurodegenerative diseases and strokes, and pharmacological inhibition of ferroptosis as a therapeutic target for these diseases. In this review article, the core mechanisms of ferroptosis are overviewed and the roles of ferroptosis in neurodegenerative diseases and strokes are described. Finally, the emerging findings in treating neurodegenerative diseases and strokes through pharmacological inhibition of ferroptosis are described. This review demonstrates that pharmacological inhibition of ferroptosis by bioactive small‐molecule compounds (ferroptosis inhibitors) could be effective for treatments of these diseases, and highlights a potential promising therapeutic avenue that could be used to prevent neurodegenerative diseases and strokes. This review article will shed light on developing novel therapeutic regimens by pharmacological inhibition of ferroptosis to slow down the progression of these diseases in the future.

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Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke

Cited by 84 publications

References 59 publications

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Neuroprotection of Sesamin against Cerebral Ischemia In-Vivo and N-Methyl-D-Aspartate-Induced Apoptosis In-Vitro

Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes

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