Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat

Lakshmikuttyamma, Ashakumary; Rouyer, Isabelle A.; Takahashi, Yōko; Ishii, Takashi; Fukuda, Nobuhiro; Aoyama, Toshifumi; Hashimoto, Takashi; Mizugaki, Michinao; Sugano, Michihiro

doi:10.1016/s0026-0495(99)90272-x

Cited by 142 publications

(137 citation statements)

References 42 publications

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“…Sesamin/episesamin exposure (0.05 mM, final concentration. This compound also increased the activity of enzymes related to β mitochondrial and peroxisomal oxidation, by activating PPARα in rats, and fish as the rainbow trout Oncorhynchus mykiss and Lates calcarifer (ASHAKUMARY et al, 1999;TRATTNER et al, 2008a;ALHAZZAA et al, 2012).…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

Sesame oil in diets for lambari: Effects on growth parameters, corporal chemical composition and physiological alterations

et al. 2016

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Section: ------------------------------------------------------------mentioning

confidence: 99%

Sesame oil in diets for lambari: Effects on growth parameters, corporal chemical composition and physiological alterations

et al. 2016

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“…Therefore, sesamin, sesamol or their metabolites decrease the activity of cyclooxygenase and the biosynthesis of prostaglandins (Chavali et al, 1998). Sesamin strongly influences lipid metabolism in experimental animals (Ashakumary et al, 1999) and in humans (Hirata et al, 1996). Hirose et al, (1991) showed that serum and liver cholesterols were reduced in rats fed diet containing 0.5% sesamin.…”

Section: Sesaminmentioning

confidence: 99%

“…Kushiro et al, (2002) reported that sesamin greatly increased the hepatic fatty acid oxidation rate. An activity and gene expression of hepatic fatty acid oxidation enzymes presumably through the activation of peroxisome proliferator activated receptor (PPAR) α, a member of the PPAR family that is abundantly expressed in the lives of living organisms (Ashakumary et al, 1999). Sesamin also increases the activity and gene expression of the malic enzyme involved in the regulation of fatty acid synthesis.…”

Section: Sesaminmentioning

confidence: 99%

Nutraceutical Importance of Sesame Seed and Oil: A Review of the Contribution of their Lignans

Kanu¹,

Bahsoon²,

Kanu³

et al. 2010

Sierra Leone j. biomed. res.

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Sesame seed is widely used in food and nutraceutical industries in many countries because of its high oil, protein and antioxidant contents. Sesame oil contains sesamin, sesamolin and sesaminol lignan fractions, which are known to play an important role in its oxidative stability and antioxidative activity. It is widely known as one of the natural health promoting foods that has the potential to prevent various disorders such as hypertension, hypercholesterolemia cancer and aging. Additionally, sesame oil may be useful in managing oxidative stress-associated diseases such as atherosclerosis, diabetes mellitus, obesity, chronic renal failure, rheumatoid arthritis, and neurodegenerative diseases including Alzheimer's disease. Moreover, sesame oil has multiple physiological functions such as decreasing blood lipids and arachidonic acid levels, increasing antioxidative ability and γ-tocopherol bioavailability, and providing anti-inflammatory function and potential estrogenic activity. Many health promoting effects are attributed to its lignans. Hence, this article highlights and discusses the potential health promoting effects of sesame and its oil with emphasis on the contribution of lignans.

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“…Takashi IDE 1 Sesamin is a potent inducer of hepatic fatty acid oxidation 2 Rats were fed purified experimental diets containing varying amounts of sesamin (0-0.5%) for 15 days. Dietary sesamin increased the mitochondrial and peroxisomal fatty acid oxidation rates dose-dependently (Fig.…”

Section: Sesamin a Sesame Lignan As A Potent Serum Lipid-lowering Fmentioning

confidence: 99%

Sesamin, a Sesame Lignan, as a Potent Serum Lipid-Lowering Food Component

Ishii

Kushiro

Takahashi

et al. 2003

JARQ

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Effect of sesamin, a sesame lignan, on the hepatic fatty acid metabolism was examined in the rat. Increase of the dietary level of sesamin progressively increased the mitochondrial and peroxisomal fatty acid oxidation rate. Mitochondrial activity almost doubled in rats fed a 0.5% sesamin diet. Peroxisomal activity became more than 10 times higher in rats fed a 0.5% sesamin diet, compared to those fed a sesamin-free diet. Dietary sesamin also markedly increased the hepatic activity and mRNA levels of various fatty acid oxidation enzymes. In contrast, dietary sesamin decreased the hepatic activity and mRNA abundance of lipogenic enzymes. This was associated with the down-regulation of sterol regulatory element-binding protein-1, a transcriptional factor that regulates the lipogenic enzyme gene expression. Dietary sesamin significantly decreased the triacylglycerol secretion accompanying the increase in ketone body production by the perfused rat liver. It is apparent that sesamin affects the fatty acid metabolism and lipoprotein production in the liver, and hence lowers the serum lipid levels. We also developed several sesame lines with seeds containing sesamin and sesamolin at twice the concentration of conventional cultivars. Compared to a conventional cultivar, these lignan-rich sesame seeds increased the hepatic fatty acid oxidation rate and lowered the serum triacylglycerol level in the rat. Therefore, it is considered that enrichment of the lignans potentiates the characteristics of sesame in improving human health.Discipline: Food Additional key words: sesame, fatty acid oxidation, fatty acid synthesis, lipoprotein production, rat JARQ 37 (3), 151 -158 (2003) http://www.jircas.affrc

show abstract

Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat

Cited by 142 publications

References 42 publications

Sesame oil in diets for lambari: Effects on growth parameters, corporal chemical composition and physiological alterations

Sesame oil in diets for lambari: Effects on growth parameters, corporal chemical composition and physiological alterations

Nutraceutical Importance of Sesame Seed and Oil: A Review of the Contribution of their Lignans

Sesamin, a Sesame Lignan, as a Potent Serum Lipid-Lowering Food Component

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