Sesame allergy: a growing food allergy of global proportions?

Gangur, Venu; Kelly, Caleb; Navuluri, Lalitha

doi:10.1016/s1081-1206(10)61181-7

Cited by 95 publications

(67 citation statements)

References 39 publications

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“…IL-10 is thought to act probably through modulation of TH1 responses and reducing the IFN-γ production which leads to disease amelioration. It has been shown that sesame oil has allergic properties [10]. Since TH2 responses are essential in most perspectives of allergic manifestations, hence sesame oil may detour the immune responses toward TH2.…”

Section: Discussionmentioning

confidence: 99%

“…Reports show that sesame oil can act as an antioxidant agent, reduce lipid peroxidation, exhibit healing effects on damaged tissue and provide anti-in lammatory function [9]. Other studies, however, disclose that sesame oil could cause allergic reactions [10]. Given the fact that TH2 cells participate in allergic reactions by producing IL-4, it could be hypothesized that sesame oil can augment the TH2 responses and consequently suppress the TH1 responses.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cytokine Modulatory Effects of Sesamum Indicum Seeds Oil Ameliorate Mice with Experimental Autoimmune Encephalomyelitis

MR¹

2017

Arch Asthma Allergy Immunol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytokine Modulatory Effects of Sesamum Indicum Seeds Oil Ameliorate Mice with Experimental Autoimmune Encephalomyelitis

MR¹

2017

Arch Asthma Allergy Immunol

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“…8,9 In this study, 2 patients showed immediate responses to perilla seed on an oral challenge test and had positive skin prick tests. In addition, high serum-specific IgE and 1 IgE-binding component were noted, indicating that perilla seed ingestion can induce severe IgE-mediated allergic symptoms.…”

Section: Two Cases Of Anaphylaxis Caused By Perilla Seedmentioning

confidence: 61%

Two cases of anaphylaxis caused by perilla seed

Jeong

Park

Choi

et al. 2006

Journal of Allergy and Clinical Immunology

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“…The number of articles on other edible seeds we encountered was far less than expected, considering the worldwide use of these seeds. Sesame appears to be emerging globally as an important allergen and hypersensitivity to it has been reported worldwide with significant geographic differences (1,2). The general prevalence of sesame allergy has been estimated at 0.1-0.2% (2).…”

Section: Epidemiologymentioning

confidence: 99%

“…However, in that report, only one of eight patients reacted (angioedema) to both sesame and hazelnut. Serologic cross-reactivity between sesame and black walnut, cashew, macadamia, pistachio, and peanuts has also been observed (1). Clinical cross-allergenicity has been reported in some sesame-sensitive patients to poppy seeds, peanut, and tree nuts (78)(79)(80)(81).…”

Section: Sesame Seed Cross-reactivitymentioning

confidence: 99%

Hypersensitivities to sesame and other common edible seeds

Patel

Bahna

2016

Allergy

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Several seeds have been increasingly incorporated in various food items, with consequent risk of hypersensitivity reactions that are often severe. Identification of the specific seed as the culprit is often not explored or is difficult to verify. In this article, we reviewed the English literature from January 1930 to March 2016 using PubMed and Google Scholar searching for publications relevant to hypersensitivity to common edible seeds, namely sesame, sunflower seed, poppy seed, pumpkin seed, flaxseed, and mustard seed. Considering the worldwide consumption of those seeds, the number of published articles on the subject was relatively small and was mainly as case reports rather than large series. Allergy to sesame was more reported than to other seeds, with an estimated prevalence of 0.1-0.2%. In this review, we summarize the information relevant to each of the six seeds and their oils regarding the manifestations, routes of exposure, identified major allergens, and cross-reactivity with other seeds or other foods. We also addressed the important role of a thorough history taking in suspecting seed allergy, the limited reliability of routine diagnostic procedures, and the importance of verification by appropriate challenge tests. At present, management is basically dietary avoidance and the use of symptomatic medications that may include epinephrine auto-injectors. We did not encounter any well-designed studies on immunotherapy for seed allergy, but it is hoped that such a gap be filled by the development of safe effective protocols in the near future.With the growing trend of incorporating seeds in diet, hypersensitivity reactions have been increasingly occurring but are rarely suspected. The problem is compounded by the difficulty in identifying the culprit and the apparent underreporting. MethodsIn this article, we review the English literature from January 1930 to March 2016 using PubMed and Google Scholar. Special attention was directed to hypersensitivity reactions to commonly consumed seeds, namely sesame, sunflower, poppy, flaxseed, and pumpkin seed, and their respective oils. We also summarize the studies on the identified allergens and the cross-reactivities among these seeds and with other foods.

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Sesame allergy: a growing food allergy of global proportions?

Cited by 95 publications

References 39 publications

Cytokine Modulatory Effects of Sesamum Indicum Seeds Oil Ameliorate Mice with Experimental Autoimmune Encephalomyelitis

Cytokine Modulatory Effects of Sesamum Indicum Seeds Oil Ameliorate Mice with Experimental Autoimmune Encephalomyelitis

Two cases of anaphylaxis caused by perilla seed

Hypersensitivities to sesame and other common edible seeds

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