Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2)

Abstract

Informatics for Integrating Biology and the Bedside (i2b2) is one of seven projects sponsored by the NIH Roadmap National Centers for Biomedical Computing (http://www.ncbcs.org). Its mission is to provide clinical investigators with the tools necessary to integrate medical record and clinical research data in the genomics age, a software suite to construct and integrate the modern clinical research chart. i2b2 software may be used by an enterprise's research community to find sets of interesting patients from electronic patient medical record data, while preserving patient privacy through a query tool interface. Project-specific mini-databases ("data marts") can be created from these sets to make highly detailed data available on these specific patients to the investigators on the i2b2 platform, as reviewed and restricted by the Institutional Review Board. The current version of this software has been released into the public domain and is available at the URL: http://www.i2b2.org/software.

Phelan‐McDermid syndrome data network: Integrating patient reported outcomes with clinical notes and curated genetic reports

“…The i2b2/tranSMART platform is layered upon the Informatics for Integrating Biology with Bedside (i2b2) clinical and biomedical data integration platform (Kohane, Churchill, & Murphy, 2012; Murphy et al, 2010). The i2b2 platform uses a simple and intuitive “observation centric” star schema data model that accommodates a variety of longitudinal patient level datasets including clinical data, prescriptions, and laboratory values.…”

Update on Data Reuse in Health Care

“…is time consuming and might interfere with clinical operations. Eventually a subset of data from each clinical encounter could be transferred into a disease-specific registry (e.g., cancer registry) or into a clinical data warehouse for future reuse [7,20,21]. This selection of only specific data elements for inclusion in a registry or warehouse results in a loss of information and context.…”

Entity Attribute Value Style Modeling Approach for Archetype Based Data

“…I2b2 is a self-service tool that has been designed (and becoming a de facto standard) specifically for patients' cohort identification. It allows to perform a population-wide search to identify the amount of patient existing as per a study-specific criteria for feasibility analysis of the underlying study [58]. To provide functionality of cohort identification and feasibility analysis, i2b2 performs analytical operations on population data.…”

“…Databases are designed to support two categories of operations, i.e., transactional (that usually demands patient specific data) and analytical (that requires population data). A popular tool, termed as Informatics for Integrating Biology and the Beside (i2b2), uses EAV for the purpose of data storage to perform analytical queries [58]. I2b2 is a self-service tool that has been designed (and becoming a de facto standard) specifically for patients' cohort identification.…”