Serumgruppen und Krankheit

Wendt, G. G.; Krüger, J.; Kindermann, Ilse

doi:10.1007/bf00286797

Cited by 14 publications

(7 citation statements)

References 30 publications

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“…Thus, duodenal ulcer (DU) is associated with blood group O [1], nonsecretor status [2] and hyperpepsinogenemia [3]. In addition, first-degree relatives of patients with DU or gastric ulcer (GU) are at increased risk of getting the same kind of ulcer [4], Some serum protein groups (Hp, GC) have already been studied in patients with peptic ulcer [5,6] diagnosed by X-rays; no sig nificant associations were found. However, as no study concerning the GC and C3 serum protein groups in patients with endoscopically confirmed peptic ulcer has been published, we investigated the possible associations of the group-specific component (GC) and the third component of complement (C3) with peptic ulcer diagnosed by endoscopy.…”

mentioning

confidence: 99%

GC and C3 Serum Groups in Peptic Ulcer

Archimandritis¹,

M²,

Grigoris³

et al. 1992

Hum Hered

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The phenotypes and gene frequencies of two serum protein systems (GC, C3) were studied in 238 consecutive patients with peptic ulcer from all over Greece. 173 patients had duodenal ulcer and 65 had gastric ulcer. Healthy Greeks studied previously in our department served as controls. No significant differences were found between the studied groups and the controls as far as GC was concerned. However, significant differences emerged in C3; the C3*F gene was almost twice more common and the C3F phenotype almost three times more frequent in patients than in controls.

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mentioning

confidence: 99%

GC and C3 Serum Groups in Peptic Ulcer

Archimandritis¹,

M²,

Grigoris³

et al. 1992

Hum Hered

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“…Various authors have shown that genetically determined haptoglobin phenotypes are associated with a variety of illnesses such as leukemia, cancer, rheumatic fever, several liver diseases, cardiovascular diseases, etc. (Wendt, 1968). Antibody-like properties have been discovered in haptoglobin, and qualitative differences in the immunological activities of the different phenotypes have also been described (Prokop and Köhler, 1977;Köhler and Prokop, 1978).…”

Section: Discussionmentioning

confidence: 99%

“…The immunogenic reactivity of the organism and the genetically determined haptoglobin phenotype are closely related (Prokop and Köhler, 1977;. Although signs of a probable relationship between haptoglobin phenotype and various illnesses have been discovered (Wendt, 1968), investigations of this sort relating to diabetes mellitus have scarcely been performed . The purpose of the clinical study described here is to find out whether haptoglobin phenotype and IDDM, circulating insulin antibodies and the incidence of diabetes-specific complications are in some way related.…”

Section: Gci = Mbg +mentioning

confidence: 99%

Is there a Relationship between Genetically Determined Haptoglobin Phenotype and Insulin-Dependent Diabetes Mellitus (IDDM)?¹)

Kp¹,

Strese²,

Keilacker³

et al. 2009

Exp Clin Endocrinol Diabetes

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The possible relationship between genetically determined haptoglobin phenotype and insulin-dependent diabetes (IDDM), circulating insulin antibodies and the occurrence of microangiopathy was studied in 144 IDDM. There were no differences regarding the distribution of Hp-phenotypes in 144 patients in comparison with a control population (n = 1726). Irrespective of the Hp-phenotype, the degree and severity of diabetic complications (retinopathy and/or nephropathy) significantly increased with the duration of diabetes. There was no relationship between Hp-phenotype and diabetic microangiopathy (retinopathy, nephropathy). No association existed between Hp-phenotype and the percentage of insulin antibody binding. Regardless of the Hp-phenotype, the insulin antibody concentration decreased with increasing duration of diabetes. Insulin binding parameters (maximum binding capacity and equilibrium dissociation constant) were found to vary considerably with the Hp-phenotypes among IDDM. For a given duration of diabetes the equilibrium dissociation constant increased significantly in the range from Hp 1-1, Hp 2-1 to Hp 2-2 phenotype. There was a direct relationship between the logarithm of the equilibrium dissociation constant and the degree of metabolic control, i.e. the lower the dissociation constant the better the metabolic balance. In conclusion, the results do not provide support for a putative relationship between Hp-phenotype and IDDM. However, differences between insulin binding parameters, in dependence on the Hp-phenotype may be of clinical importance.

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“…The studies of HP type distribution among carriers of malignant tumours, starting soon after the discovery of their polymorphism, revealed no significant correlation, except for over-representation of HP 1-1 among patients with leukaemia [6].…”

Section: Introductionmentioning

confidence: 99%

The development of osteosarcoma in four-fold selected group of patients

Becker

Geserick

Schmidt-Peter³

et al. 1991

International Orthopaedics

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Patients with osteosarcoma have been submitted to four-fold selection using parameters previously shown to be associated factors. These are sex, age at onset, haptoglobins and histological type. Further data have been added to the final resulting sequence of patients. In the four-fold selected group there is an age-dependent AB0 distribution which confirms the relevance of the criteria used and, consequently, the influence on sarcoma development. It can be assumed from these investigations that the occurrence of osteosarcoma is modified by several genetically fixed factors (HP type, sex, AB0 group).

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Serumgruppen und Krankheit

Cited by 14 publications

References 30 publications

GC and C3 Serum Groups in Peptic Ulcer

GC and C3 Serum Groups in Peptic Ulcer

Is there a Relationship between Genetically Determined Haptoglobin Phenotype and Insulin-Dependent Diabetes Mellitus (IDDM)?¹)

The development of osteosarcoma in four-fold selected group of patients

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Serumgruppen und Krankheit

Cited by 14 publications

References 30 publications

GC and C3 Serum Groups in Peptic Ulcer

GC and C3 Serum Groups in Peptic Ulcer

Is there a Relationship between Genetically Determined Haptoglobin Phenotype and Insulin-Dependent Diabetes Mellitus (IDDM)?1)

The development of osteosarcoma in four-fold selected group of patients

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Is there a Relationship between Genetically Determined Haptoglobin Phenotype and Insulin-Dependent Diabetes Mellitus (IDDM)?¹)