Serum-γ-Glutamyltranspeptidase (γ-GT) and Aspartate-Aminotransferase (AspAT) Activities in Adult Cattle with Chronic Fasciola Hepatica Infection

Simesen, M. G.; Nansen, P.

doi:10.1186/bf03547484

Cited by 18 publications

(7 citation statements)

References 3 publications

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“…In view of the herd's history of fasciolosis, the eosinophilia in in-contact cows, the hepatic fibrosis and non-specific enteritis, it seems likely that these calculi represent an end stage of Fasciola hepatica infection (West and Hogg, 1988). The clinical and post-mortem changes in the overt cases of fasciolosis agreed with the observations of Simesen and Nansen (1974).…”

Section: Clinical and Necropsyfindingssupporting

confidence: 68%

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West

1997

Veterinary Research Communications

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In cattle with hepatic lipidosis, hepatic abscessation, leptospirosis, biliary calculi or fasciolosis, the progression of the disease was studied by serial measurements of serum total bile acid concentrations, plasma glutamate dehydrogenase, gamma-glutamyltransferase, 5'-nucleotidase and leucine aminopeptidase activities Terminalia avicennioides and by liver biopsy. Regardless of the cause of the hepatic disease, weight loss, anorexia, dullness and depression were consistent features. Signs of hepatic encephalopathy, such as blindness, head pressing, excitability, ataxia and weakness were less common and, together with pyrexia and jaundice, were grave prognostic signs. Plasma ammonia concentrations were significantly elevated compared to clinically normal cattle, but such changes were not always accompanied by a decline in plasma urea concentrations. In normal, healthy cattle, the plasma ammonia:urea concentration ratio is 9:1 and the plasma ammonia:glucose concentration is 11:1. In hepatic disease, a plasma ammonia:glucose ratio > 40:1 or plasma ammonia:urea ratio > 30:1, particularly with a rising total ketone body concentration and a declining glucose concentration, carried a guarded prognosis. The study suggested that other factors, such as hypokalaemia, alkalosis, short-chain volatile fatty acids, and false and true neuro-transmitters, may be important in the pathogenesis of hepatic coma in cattle.

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Section: Clinical and Necropsyfindingssupporting

confidence: 68%

“…Certainly, experimental evidence exists that yGT is released in biliary tract damage (Simesen and Nansen, 1974;Craig et al. 1978).…”

Section: Clinical Chemistrymentioning

confidence: 99%

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West

1997

Veterinary Research Communications

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“…In contrast, the serum values of GGT increased after infection (Bulgin et al, 1984). In another study in Denmark, analyses of GGT and AST activities in infected animals revealed no significant increase in either (Simensen & Nansen, 1974).…”

Section: Discussionmentioning

confidence: 85%

“…To explain this difference, Simensen & Nansen (1974) proposed that: (1) the infected cows in the study were adult cattle, which may have grazed in wet, lowland areas with snail habitats at least twice, or usually for several seasons, before slaughter; or (2) there were decreased numbers of established parasites following successive grazing seasons because the cows had a considerable resistance to infection.…”

Section: Discussionmentioning

confidence: 99%

“…Other biochemical changes that occur in infected animals are increased activities of the serum enzymes γ-glutamyl transpeptidase (GGT) and aspartate aminotransferase (AST) caused by liver injury due to F. hepatica infection (Anderson et al , 1977; Wensvoort & Over, 1982; Wycoff & Bradley, 1985; Yang et al , 1998; Bossaert et al , 1999; Gajewswka et al , 2005). However, enzyme analyses in other studies have shown no significant increases in AST, GGT and alkaline phosphatase (ALP) activities as compared to those of uninfected animals (Simensen & Nansen, 1974; Bulgin et al , 1984). In the present study, the effects of chronic infection of cattle with F. hepatica on haematological indices, serum iron status and hepatic enzyme activities were investigated, in order to elucidate the underlying aetiology of anaemia in infected animals.…”

Section: Introductionmentioning

confidence: 96%

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The relationship between normocytic, hypochromic anaemia and iron concentration together with hepatic enzyme activities in cattle infected withFasciola hepatica

et al. 2008

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Erythrograms determined from whole blood analyses and serum analyses for aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) activities, and iron concentration, were used in infected and uninfected cattle to determine the type of anaemia and degree of hepatic damage caused by Fasciola hepatica. Blood samples from 86 infected and 30 uninfected cattle were taken at slaughter. Haematological analyses revealed decreased levels of packed cell volume (PCV), haemoglobin concentration, mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) in infected compared with uninfected cattle (P < 0.05). A decrease in the concentration of serum iron was also observed in infected cattle compared with uninfected cattle (P < 0.05). Significant increases in AST, GGT and ALP activities were observed in cattle infected with F. hepatica when compared with uninfected cattle (P < 0.05). It was concluded that the anaemia observed in cattle infected with F. hepatica is a normocytic, hypochromic anaemia and the most important aetiology of the anaemia is the chronic blood loss due to the blood-sucking activity of the adult flukes and leakage of blood from the bile duct to the intestine, which results in iron deficiency. The increased activities of serum enzymes indicated chronic hepatic and bile duct injuries associated with chronic infection with F. hepatica.

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Gamma Glutamyl Transferase in domestic animals

Braun¹,

Bénard²,

Burgat³

et al. 1983

Vet Res Commun

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In domestic animals, Gamma Glutamyl Transferase is mainly in the kidneys, the pancreas and the intestine; its liver activity is relatively high in cows, horses, sheep and goats and very low in dogs, cats and birds. The use of plasma reference values can help to interpret the variations of serum GGT mainly in hepatobiliary diseases of cattle, sheep, goats and cholestatic disorders of dogs. Urinary GGT is a good test of kidney toxic damage.

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Serum-γ-Glutamyltranspeptidase (γ-GT) and Aspartate-Aminotransferase (AspAT) Activities in Adult Cattle with Chronic Fasciola Hepatica Infection

Cited by 18 publications

References 3 publications

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The relationship between normocytic, hypochromic anaemia and iron concentration together with hepatic enzyme activities in cattle infected withFasciola hepatica

Gamma Glutamyl Transferase in domestic animals

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