Serum βhCG and Lipid Profile in Early Second Trimester as Predictors of Pregnancy-Induced Hypertension

Abstract

Objectives A variety of biological, biochemical, and biophysical markers implicated in the pathophysiology of preeclampsia during the last two decades have instigated the growing interest in this study to include both bhCG and lipid profile studies in the early second trimester as early predictors of pregnancy-induced hypertension. Early identification of at-risk women may help in taking timely preventive and curative management to prevent or delay complications associated with pregnancy-induced hypertension. Method A prospective study was performed on 120 patients attending the outpatient department of the Obstetrics and Gynaecology of the Maharaja Agrasen Hospital. All the patients were screened for serum bhCG and serum lipid profile in their early second trimester (14-20 weeks) and followed up till their delivery. Comparative studies of serum bhCG and serum lipid profile were performed between those who remain normotensive (group I) and those who developed pregnancy-induced hypertension (group II).Results TG, total cholesterol, VLDL, and LDL values for those women who developed PIH (group II) were significantly higher than those who remain normotensive (group I), with p value of\0.05 which is statistically significant. HDL and bhCG values for group II were not higher than those in group I with p value[0.05 which is statistically insignificant. Conclusion Maternal lipid profile in second trimester is very good noninvasive test which can be used for prediction of pregnancy-induced hypertension before its clinical onset. However, there is no correlation between maternal serum bhCG and pregnancy-induced hypertension.

Assessment of serum β‐hCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy

“…In Yadav et al. 's study of 120 pregnant women, the lipid profile was elevated in hypertensive women as compared with normotensive women ( P< 0.05), but β‐hCG was not, by contrast with the present findings. In a study of β‐hCG, α‐fetoprotein, and inhibin A levels among 50 pregnant women, Dayal et al .…”

“…Both Vidyabati et al . and Yadav et al . reported a significant lipid profile among prenatal women who subsequently developed hypertension.…”

Inhibition of the JAK2/STAT3/SOSC1 Signaling Pathway Improves Secretion Function of Vascular Endothelial Cells in a Rat Model of Pregnancy-Induced Hypertension

“…PIH induces a wide variety of disorders, such as gestational hypertension, preeclampsia and eclampsia [4]. Early diagnoses, antenatal surveillance, and timely intervention are important for PIH management [5], but currently, no cost-effective, reliable and reproducible screening test is available for PIH. Endothelial dysfunction may be a predisposing factor for obstetric complications, such as preeclampsia and PIH [3].…”

Serum Beta‐Trace Protein as a Novel Predictor of Pregnancy‐Induced Hypertension

“…Hypertensive pregnant women are at increased risk for later cardiovascular disease and mortality regardless of their proteinuric status . Early diagnosis, close antenatal surveillance, and timely intervention are key to the management of PIH . Currently, there are no reliable, economic, and reproducible screening tests available.…”

“…6,7 Early diagnosis, close antenatal surveillance, and timely intervention are key to the management of PIH. 8 Currently, there are no reliable, economic, and reproducible screening tests available.…”