Serum α2-HS Glycoprotein Predicts Survival in Patients with Glioblastoma

Petrik, Vladimir; Saadoun, Samira; Loosemore, Alison; Hobbs, Josie; Opstad, Kirstie S.; Sheldon, Joanna; Tarelli, Edward; Howe, Franklyn A.; Bell, B. Anthony; Papadopoulos, Marios C.

doi:10.1373/clinchem.2007.096792

Cited by 70 publications

(66 citation statements)

References 29 publications

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“…The peptide mimicked AHSG, also known as fetuin-A, and we suggest that serum reactivity to fetuin-A shows utility as a sensitive and specific indicator of metastatic disease. Whereas fetuin-A has been implicated as a tumor antigen in several cancer types such as breast cancer (13), glioblastoma (14), and pancreas cancer (15), to our knowledge this report is the first to show involvement of fetuin-A in prostate cancer. We investigated the expression of fetuin-A in a panel of prostate cancer cell lines and observed robust expression of fetuin-A for the highly metastatic PC-3 cells, indicating that expression levels might correlate with metastatic potential as found previously for angiogenic factors (16).…”

Section: Discussionmentioning

confidence: 62%

Discovery and horizontal follow-up of an autoantibody signature in human prostate cancer

Mintz¹,

Rietz

Cardó-Vila

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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In response to an urgent need for improved diagnostic and predictive serum biomarkers for management of metastatic prostate cancer, we used phage display fingerprinting to analyze sequentially acquired serum samples from a patient with advancing prostate cancer. We identified a peptide ligand, CTFAGSSC, demonstrating an increased recovery frequency over time. Serum antibody reactivity to this peptide epitope increased in the index patient, in parallel with development of deteriorating symptoms. The antigen mimicking the peptide epitope was identified as alpha-2-HeremansSchmid glycoprotein, also known as fetuin-A. Metastatic prostate cancer cell lines and bone metastasis samples displayed robust fetuin-A expression, and we demonstrated serum immune reactivity to fetuin-A with concomitant development of metastatic castrateresistant disease in a large cohort of prostate cancer patients. Whereas fetuin-A is an established tumor antigen in several types of cancer, including breast cancer, glioblastoma, and pancreas cancer, this report is to our knowledge the first study implicating fetuin-A in prostate cancer and indicating that autoantibodies specific for fetuin-A show utility as a prognostic indicator for prostate cancer patients prone to progress to metastatic disease.cancer biomarker | peptide library | prostate cancer | phage display

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Section: Discussionmentioning

confidence: 62%

Discovery and horizontal follow-up of an autoantibody signature in human prostate cancer

Mintz¹,

Rietz

Cardó-Vila

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…In patients with glioblastoma, the most commonly occurring brain tumor low serum fetuin-A levels predicted poor survival (38). Moreover, Rho and colleagues (39) report differential expression of fetuin-A between lung adenocarcinoma and adjacent normal tissue with both total protein and mRNA abundance reduced in cancer samples.…”

Section: Discussionmentioning

confidence: 99%

Telomere Attrition and Decreased Fetuin-A Levels Indicate Accelerated Biological Aging and Are Implicated in the Pathogenesis of Colorectal Cancer

Maxwell

McGlynn

Muir

et al. 2011

Clinical Cancer Research

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Purpose: Increasing chronological age is a risk factor for many types of cancer including colorectal. An understanding of the biology of aging and factors which regulate it may provide insight into cancer pathogenesis. The role of telomere biology in both the cancer and aging process could prove useful in this regard.Experimental Design: Using quantitative PCR, we determined telomere length in the peripheral blood leukocytes of 64 colorectal cancer (CRC) patients and 1,348 controls. We also measured telomere length in 32 colorectal tumor samples and matched normal tissue. We aimed to assess whether telomere lengths were reflected in circulating mediators of inflammation and redox control factors, including fetuin-A, a circulating modulator of calcium homeostasis. Conclusions: We have observed that patients with CRC display clear evidence of telomere attrition compared with controls.

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“…These techniques include ELISA (Hormigo et al, 2006;Lin et al, 2009;Sreekanthreddy et al, 2010), 2-DE (Khwaja et al, 2007;Khalil, 2007;Ohnishi et al, 2009), DNA microarray , (Petrik et al, 2008;Schwartz et al, 2005),direct sequencing (Sanson et al, 2009), ICAT (Khwaja et al, 2007), and transgenic mouse etc (Sodaa et al, 2011). A number of quantitative approaches summarized in Figure 1, with different technical advantages and challenges, have been developed for glioma biomarker discovery.…”

Section: Discussion and Outlookmentioning

confidence: 99%

“…Therefore, gelsolin may be a prognostic marker for astrocytoma patients (Ohnishi et al, 2009). Besides, the B-chain of 2 -heremans-schmid glycoprotein in serum can be used as a potential biomarker for glioma prognosis (Petrik et al, 2008). DNA microarray is usually used to measure gene expression levels, single nucleotide polymorphisms or genotype.…”

Section: Prognostic Biomarkers For Gliomamentioning

confidence: 99%

Biomarkers of Glioma

Liang¹,

Shen²

2011

Molecular Targets of CNS Tumors

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Serum α2-HS Glycoprotein Predicts Survival in Patients with Glioblastoma

Abstract: BACKGROUND: Glioblastoma, the most common primary brain tumor, has variable prognosis. We aimed to identify serum biomarkers that predict survival of patients with glioblastoma.

Cited by 70 publications

References 29 publications

Discovery and horizontal follow-up of an autoantibody signature in human prostate cancer

Discovery and horizontal follow-up of an autoantibody signature in human prostate cancer

Telomere Attrition and Decreased Fetuin-A Levels Indicate Accelerated Biological Aging and Are Implicated in the Pathogenesis of Colorectal Cancer

Biomarkers of Glioma

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