Serum zonulin and claudin-5 levels in patients with bipolar disorder

Kılıç, Faruk; Işık, Ümit; Demirdaş, Arif; Doğuç, Duygu Kumbul; Bozkurt, Mehtap

doi:10.1016/j.jad.2020.01.117

Cited by 45 publications

(31 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 47 Studies have also shown that gut permeability markers are linked to psychiatric disorders. 48 , 49 Thus, a further limitation in our study was that we did not evaluate gut dysbiosis/permeability, which could have affected TWEAK levels. This could be a relevant confounding factor that should be considered in future research.…”

Section: Discussionmentioning

confidence: 99%

Serum tumor necrosis factor-like weak inducer of apoptosis levels are elevated in schizophrenia

Kılıç

Işık

Usta

et al. 2021

Braz. J. Psychiatry

Self Cite

View full text Add to dashboard Cite

The purpose of this study was to assess serum Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) concentrations to determine whether changes in patients with schizophrenia could have etiopathogenetic importance. Since very little research has addressed the connection between the inflammatory marker TWEAK and schizophrenia, we wanted to examine alterations of TWEAK and investigate the possible correlation between clinical symptomatology and serum concentrations. Methods: A total of 45 schizophrenia patients and 40 healthy controls were included in this study. The Positive Symptom Assessment scale and the Negative Symptom Assessment scale were administered to determine symptom severity. Venous blood samples were collected and serum TWEAK levels were measured. Results: Serum TWEAK levels were significantly higher in the schizophrenia group than the control group, independently of potential confounders, including sex, age, body mass index and smoking status. Conclusion: The results indicate that TWEAK is elevated in schizophrenia patients, which could deepen our understanding of the role of inflammation in the pathogenesis of schizophrenia.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum tumor necrosis factor-like weak inducer of apoptosis levels are elevated in schizophrenia

Kılıç

Işık

Usta

et al. 2021

Braz. J. Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, the intestinal barrier function is affected in several gastro-intestinal disorders such as IBD, IBS, celiac disease and obesity leading to a ‘leaky gut’ and an increased flux of luminal compounds towards the circulation 56 . Also in mental disorders such as ASD, ADHD and bipolar disorder, increased serum zonulin and/or claudin-5 levels are observed which is associated with respectively increased intestinal and BBB permeability 60 , 61 .…”

Section: Discussionmentioning

confidence: 99%

PapRIV, a BV-2 microglial cell activating quorum sensing peptide

Janssens

Debunne

Spiegeleer

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Quorum sensing peptides (QSPs) are bacterial peptides produced by Gram-positive bacteria to communicate with their peers in a cell-density dependent manner. These peptides do not only act as interbacterial communication signals, but can also have effects on the host. Compelling evidence demonstrates the presence of a gut-brain axis and more specifically, the role of the gut microbiota in microglial functioning. The aim of this study is to investigate microglial activating properties of a selected QSP (PapRIV) which is produced by Bacillus cereus species. PapRIV showed in vitro activating properties of BV-2 microglia cells and was able to cross the in vitro Caco-2 cell model and reach the brain. In vivo peptide presence was also demonstrated in mouse plasma. The peptide caused induction of IL-6, TNFα and ROS expression and increased the fraction of ameboid BV-2 microglia cells in an NF-κB dependent manner. Different metabolites were identified in serum, of which the main metabolite still remained active. PapRIV is thus able to cross the gastro-intestinal tract and the blood–brain barrier and shows in vitro activating properties in BV-2 microglia cells, hereby indicating a potential role of this quorum sensing peptide in gut-brain interaction.

show abstract

“…Moreover, the intestinal barrier function is affected in several gastro-intestinal disorders such as IBD, IBS, celiac disease and obesity leading to a 'leaky gut' and an increased flux of luminal compounds towards the circulation [65]. Also in mental disorders such as ASD, ADHD and bipolar disorder, increased serum zonulin and/or claudin-5 levels are observed which is associated with respectively increased intestinal and BBB permeability [69,70].…”

Section: Discussionmentioning

confidence: 99%

PapRIV, a BV-2 microglial cell activating quorum sensing peptide

Janssens

Debunne

Spiegeleer

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundQuorum sensing peptides (QSPs) are bacterial peptides produced by Gram-positive bacteria to communicate with their peers in a cell-density dependent manner. These peptides do not only act as interbacterial communication signals, but can also have effects on the host. Compelling evidence demonstrates the presence of a gut-brain axis and more specifically, the role of the gut microbiota in microglial functioning. The aim of this study is to investigate microglial activating properties of a selected QSP (PapRIV) which is produced by Bacillus cereus species.MethodsGastro-intestinal transport of the peptide is investigated using the in vitro Caco-2 model while transport over the blood-brain barrier is investigated in mice using multiple time regression experiments. Microglial activation is assessed using ELISA, fluorometry, immunoblotting, qPCR and phase-contrast microscopy. In vivo plasma detection and ex vivo metabolization experiments are performed using UHPLC-MS2 and UHPLC-UV/MS, respectively.ResultsPapRIV showed in vitro activating properties of BV-2 microglia cells and was able to cross the in vitro Caco-2 cell model and pass the blood-brain barrier in vivo. In vivo peptide presence was also demonstrated in mouse plasma. The peptide caused induction of IL-6, TNFα and ROS expression and increased the fraction of ameboid BV-2 microglia cells in an NF-κB dependent manner. Different metabolites were identified in serum, of which the main metabolite (DLPFEH) still remained active.ConclusionsPapRIV is thus able to cross the gastro-intestinal tract and the blood-brain barrier and shows in vitro activating properties in BV-2 microglia cells, hereby indicating a potential role of this quorum sensing peptide in gut-brain interaction.

show abstract

Serum zonulin and claudin-5 levels in patients with bipolar disorder

Cited by 45 publications

References 39 publications

Serum tumor necrosis factor-like weak inducer of apoptosis levels are elevated in schizophrenia

Serum tumor necrosis factor-like weak inducer of apoptosis levels are elevated in schizophrenia

PapRIV, a BV-2 microglial cell activating quorum sensing peptide

PapRIV, a BV-2 microglial cell activating quorum sensing peptide

Contact Info

Product

Resources

About