Serum Zinc Levels in Patients with Basal‐Cell Carcinoma

Adler, Alvin L.; Safai, Bijan; Wang, Ying B.; Menendez‐Botet, Celia J.; Good, Robert A.

doi:10.1111/j.1524-4725.1981.tb00188.x

Cited by 6 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study dealing with the importance of zinc, SZC and to some extent SCC during malignancy and following successful treatment reveals that there was a change in the level of SZC with induction of tumor and it inversely correlated with the progression of a tumor. Depression of SZC has also been observed in several human malignancies [ 13 ]. In this study, SZC showed an inverse correlation with the progression of the disease.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Zinc Level Under Malignant Condition and Its Possible Implication on Improving Cell-Mediated Immunity During Cancer Progression

Chakravarty

2011

World J Oncol

View full text Add to dashboard Cite

BackgroundZinc is an essential trace element required for different biological functions in a living body. Evaluating its concentration and effect during malignancy is important not only to assess the disease activity but also to evaluate its role in some important biological activities like immunity.MethodsThe experiments were carried out in transplanted, chemically induced and spontaneous tumors in mice. The serum zinc concentration (SZC) was determined under malignant condition and following treatment of solid tumor with anti-cancer agents. The importance of evaluating Cu/Zn ratio (CZR) was also determined. To evaluate its role in immune response during malignancy, studies were carried out on induced tumor bearing animals.ResultsThe results showed that SZC had an inverse correlation with the progression of the disease. It was significantly reduced in all forms of malignancy, more so in spontaneous and induced forms of the disease. Extensive studies done with the solid form of induced tumor, established the importance of estimating the concentration of Zn, in addition to that of copper, in assessing the disease activity following treatment with anti-cancer agents. With regression of the tumor mass, there was a significant elevation in the SZC and depression in the serum copper concentration (SCC) compared to their levels prior to treatment. This was also reflected on the value of copper zinc ratio (CZR); with the onset of tumor regression, a significant reduction in CZR was noted in the tumor bearing animals compared to their untreated levels. As the state of ‘regression’ in the tumor mass was maintained for a considerable period of time following treatment with anti-cancer agents along with elevated zinc levels, we considered the role of zinc in controlling the tumor growth, indirectly. We observed that zinc is able to stimulate lymphocyte proliferation that may directly impact on the immune response of tumor bearing host.ConclusionsZinc appears to play a role in tumor progression and regression and in stimulating lymphocyte proliferation. It is hypothesized that supplementing zinc to malignant subjects prior to and following therapeutic intervention with anti-cancer agents could help improve immune response of the host against existing tumor.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Zinc Level Under Malignant Condition and Its Possible Implication on Improving Cell-Mediated Immunity During Cancer Progression

Chakravarty

2011

World J Oncol

View full text Add to dashboard Cite

show abstract

“…However, the changes which occur are often conflicting and may depend upon the zinc requirement of the particular tumor compared to normal tissue or whether the tissue in which the tumor develops has a relatively high zinc content (1). For example, a significant elevation of serum zinc was found in patients with basal-cell carcinoma (2), malignant tumor of the uterus (3), and primary osteosarcoma without metastases (4). Decreased zinc levels have been observed in the serum of patients with non-Hodgkin's lymphoma (5), lung cancer (6), and in the plasma of children with untreated leukemia (7).…”

mentioning

confidence: 98%

Changes in Serum, Liver, and Tumor Zinc Levels during Plasmacytoma Growth in BALB/c Mice

Fenton¹,

Burke²

1983

Experimental Biology and Medicine

View full text Add to dashboard Cite

show abstract

Zinc and copper in breast cancer. A joint study in northern italy and southern france

Cavallo

Gerber²,

Pujol³

et al. 1991

Cancer

View full text Add to dashboard Cite

The relationship between breast cancer and two trace elements, zinc (Zn) and copper (Cu), was investigated by means of an hospital based case-control study at Milan (Italy) and Montpellier (France). Variables concerning dietary intake of Zn and Cu (in Milan) and their blood levels (both in Milan and Montpellier) were measured. Dietary intake, evaluated through a questionnaire of the dietary history type, and blood levels of Zn and Cu were measured in 261 cases and 261 controls. Cu blood level showed a contradictory tendency in the two samples (higher in controls in Milan, higher in cases in Montpellier), which tended to lessen after adjustment for related variables. No odds ratios (OR) in the different quantiles, nor X2 for trend reached statistical significance. A sharp difference was evidenced on the opposite with regard to Zn blood values in cases and controls. In both samples Zn mean values are significantly higher in cases than in controls, and the difference remains significant in the two samples even after adjustment for related variables. The pooled OR computed from the two samples, after adjustment for known risk factors and related variables, reaches in the fourth quartile a value of 9.5 (CI: 4.9-18.2). Dietary intake of the two minerals (measured only in Milan sample) showed no difference between cases and controls, but a stronger relationship between dietary and blood Zn was evidenced in cases with respect to controls. The authors suggest that the higher Zn level in cases might be related with an higher incorporation of Zn in cancer cases and that the same mineral might play a possible role in tumor growth promotion.

show abstract

Serum Zinc Levels in Patients with Basal‐Cell Carcinoma

Cited by 6 publications

References 16 publications

Evaluation of Serum Zinc Level Under Malignant Condition and Its Possible Implication on Improving Cell-Mediated Immunity During Cancer Progression

Evaluation of Serum Zinc Level Under Malignant Condition and Its Possible Implication on Improving Cell-Mediated Immunity During Cancer Progression

Changes in Serum, Liver, and Tumor Zinc Levels during Plasmacytoma Growth in BALB/c Mice

Zinc and copper in breast cancer. A joint study in northern italy and southern france

Contact Info

Product

Resources

About