Serum zinc levels in healthy subjects from southeastern Spain

Martin-Lagos, Francisco de Borja De Carlos; Navarro-Alarcón, Miguel; Terrés-Martos, C.; Serrana, H. López-García de la; López-Martínez, María C.

doi:10.1007/bf02784040

Cited by 10 publications

(3 citation statements)

References 25 publications

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“…Serum Zn concentration also varies between populations with diets that lack animal-sourced foods, leading to a high risk of Zn deficiency ( 49 ) . The Zn concentration used in our studies is similar to previous in vitro experiments, and is within normal serum reference ranges reflecting those achieved by healthy Western diets ( 50 , 51 ) . Thus, Zn tissue levels of this concentration could augment the anti-osteoclastic effect of coumestrol and genistein, which in turn could limit the excessive resorption associated with post-menopausal osteoporosis and osteomyelitis.…”

Section: Discussionsupporting

confidence: 84%

Zinc modifies the effect of phyto-oestrogens on osteoblast and osteoclast differentiationin vitro

Fox

2012

Br J Nutr

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Osteoblast and osteoclast activity is disrupted in post-menopausal osteoporosis. Thus, to fully address this imbalance, therapies should reduce bone resorption and promote bone formation. Dietary factors such as phyto-oestrogens and Zn have beneficial effects on osteoblast and osteoclast activity. However, the effect of combinations of these factors has not been widely studied. We therefore examined the effect of coumestrol, daidzein and genistein in the presence or absence of zinc sulphate (Zn) on osteoclast and osteoblast activity. Osteoclast differentiation and bone resorption were significantly reduced by coumestrol (10− 7 m), daidzein (10− 5 m) and genistein (10− 7 m); and this direct anti-osteoclastic action was unaffected by Zn (10− 5 m). In addition, Zn augmented the inhibitory effect of phyto-oestrogens on the osteoblast-derived stimulus for osteoclast formation, significantly reducing the ratio of receptor activator of NF-κB ligand (RANKL)-to-osteoprotegerin mRNA expression in human osteoblast. We then examined the effect of these compounds on osteoblast activity. Mineralisation was enhanced by coumestrol (10− 5to 10− 7 m), daidzein (10− 5to 10− 6 m) and genistein (10− 5 m); and Zn significantly augmented this response. Zn and phyto-oestrogens also significantly enhanced alkaline phosphatase activity and Runt-related transcription factor 2 (Runx2) mRNA expression. On the other hand, Zn blunted phyto-oestrogen-induced type I collagen and osteocalcin expression and suppressed coumestrol and daidzein-stimulated osterix expression. Zn may therefore modify the anabolic action of phyto-oestrogens, promoting characteristics associated with early rather than late stages of osteoblast differentiation. Our data suggest that while Zn enhances the anti-osteoclastic effect of phyto-oestrogens, it may limit aspects of their anabolic action on bone matrix formation.

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Section: Discussionsupporting

confidence: 84%

Zinc modifies the effect of phyto-oestrogens on osteoblast and osteoclast differentiationin vitro

Fox

2012

Br J Nutr

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“…On the other hand, higher mean serum Se values (122 Ìg/l) were reported in a population from Singapore [44]. The serum Zn levels in our study were very similar to those reported by Martin-Lagos et al [45], where the mean concentration of serum Zn was 0.951 mg/l.…”

Section: Discussionsupporting

confidence: 80%

Serum Values of Copper, Zinc and Selenium in Adults Resident in Kuwait

Al‐Sayer¹,

Al-Bader

Khoursheed³

et al. 2000

Med Princ Pract

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Objective: The populations of Kuwait and other Arabian Gulf States are very heterogeneous. Expatriates with different dietary habits constitute approximately 60% of the Kuwaiti population. The aim of this study was to establish a reference range of trace element levels in the serum of the normal population in Kuwait. Method: A total of 379 healthy males (n = 262) and females (n = 117) of various nationalities living in the State of Kuwait were studied. The serum concentrations of zinc (Zn), copper (Cu) and selenium (Se) were measured and the copper/zinc (Cu/Zn) ratio was calculated. Results: The study established the serum Zn, Cu and Se levels in the studied population. The results showed that there was no significant difference in the serum levels of these elements among the different nationalities tested. A significantly higher serum Cu level and Cu/Zn ratio were seen in females. Conclusion: These findings can form the basis and reference for any future studies on trace elements in different pathologic conditions in the Arabian Gulf region.

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“…Zn excess may result in anaemia, electrolyte imbalance, lethargy and symptoms of copper and iron deficiency, weak immune system, nausea, vomiting, gastrointestinal irritation, hypocupremia, red blood cell microcytosis and nutropenia. 12,13 The significance of zinc in menopausal nutrition and public health was recognized relatively recently. Since then, zinc insufficiency has been recognized by a number of experts as an important public health issue, especially in developing countries.…”

Section: Introductionmentioning

confidence: 99%

Serum Zinc Status in Post Menopausal Women Attending in a Tertiary Care Hospital of Bangladesh

Ferdous¹,

Mishu

Shamsunnahar³

et al. 2019

Birdem Med J

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Background: Nutritional needs change throughout the various stages of life. While overall caloric needs tend to decrease with age, the requirements for individual micronutrients do not decrease. In fact, the needs for some micronutrients actually increase with age. The risk of nutritional disturbances mainly trace elements deficiencies is high during postmenopause causing or intensifying serious clinical symptoms. Methods: This cross-sectional study was carried out in the Department of Biochemistry, Mymensingh Medical College in collaboration with the Department of Obstetrics and Gynecology , Mymensingh Medical College Hospital during the period from July 2013 to June 2014. A total of 100 subjects were included in this study. Among them 50 apperantly healthy postmenopausal womenaged between 45-70 years were considered as case and another 50 regular menstruating premenopausal women aged between 30-40 years were selected as control. Results: The mean age of case and control groups was 50.5± 2.3 years and 36.5± 4.4 years respectively. In this study serum zinc levels in cases and controls were 71.54 ± 5.69 ìg /dl and 74.68 ± 5.453 ìg/dl respectively, and there was significant difference(p<0.01). Conclusion: Serum zinc level was significantly decreased in postmenopausal group in comparison to premenopausal women (p< 0.01). Estimation of serum zinc levels might be incorporated in every postmenopausal for possible prevention of complications. Birdem Med J 2019; 9(2): 147-150

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Serum zinc levels in healthy subjects from southeastern Spain

Cited by 10 publications

References 25 publications

Zinc modifies the effect of phyto-oestrogens on osteoblast and osteoclast differentiationin vitro

Zinc modifies the effect of phyto-oestrogens on osteoblast and osteoclast differentiationin vitro

Serum Values of Copper, Zinc and Selenium in Adults Resident in Kuwait

Serum Zinc Status in Post Menopausal Women Attending in a Tertiary Care Hospital of Bangladesh

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