Serum Zinc Levels and Their Relationship with Diseases in Racehorses

Abstract

Zinc is one of the essential microelements involved in the regulation of enzyme activity, as well as metabolism of nucleic acid and proteins. There have been few reports on equine serum zinc concentrations during the training period, and little is known about the relationship between zinc levels and diseases in horses. In this study, we measured serum zinc levels in healthy Thoroughbred racehorses, as well as in other horses, under general disease or training conditions. The reference value for serum zinc levels in Thoroughbred horses was 41-79 μg/dl. There were no differences in serum zinc levels due to sex or age. Significant decreases in serum zinc levels were observed after training, but serum zinc levels did not vary with intensity of sweating. Serum zinc levels were lower in horses clinically diagnosed as having shipping fever (36.3 ± 2.7 μg/dl), fever (45.3 ± 3.0 μg/dl) and cellulitis (44.0 ± 3.4 μg/dl), as compared to control values (59.7 ± 9.7 μg/dl). They also tended to decrease in experimentally infected horses one day after inoculation. Changes in serum zinc levels reached nadir one day after surgical invasion, except for a horse that experienced complicating shock. These results suggest that zinc is a serological indicator of inflammatory status in Thoroughbred horses.

Changes in the Level of Calcium, Zinc and Copper in the Serum of Horses in Relation to the Feeding Season

“…A deficiency of this element may also occur in horses due to impaired zinc absorption from the gastrointestinal tract, which affects the pool of reserves of this element in the body (Schryver et al 1980). A reduction in zinc concentration is also observed in horses with respiratory disease or piroplasmosis (Murase et al 2013). Changes in serum concentration of zinc may result from the antagonistic interaction of Zn and Ca during absorption from the gastrointestinal tract, which impairs utilization of Zn in horses (Danek et al 1995).…”

A confocal immunofluorescence study on the expression and localisation of zinc homeostasis- related proteins in breast and prostate cancer cells

“…The cells were cultured at 37°C, 5% CO 2 and observed daily. According to the formulations of the media used here and the available data for the zinc contents in foetal bovine serum (McClung and Bobilya 1999) and horse serum (De et al 1988;Murase et al 2013), the base level of zinc for the complete DMEM, Leibovitz's L-15 and RPMI 1640 media is approximately 5 µM, for the complete DMEM/F12 approximately 2 µM and for the complete keratinocyte serum free medium 0.5 µM.…”

Selenium, copper and zinc contents in brown, black and white mane, coat and tail hairs in horses of two locations

“…Für Haaranalysen bei Pferden wurden von in Ostdeutschland, Polen und Ungarn sowie Asano et al ( , 2005aAsano et al ( , 2005c in Japan MH, von Cape und Hinz (1982) in Ithaka, USA, sowie Wichert et al (2002) Bei diagnostischen Fragen reflektieren Blutanalysen für Se, Cu und Zn aktuelle Mangelsituationen gut, die Haaranalyse informiert über mögliche Versorgungsstörungen in längeren Zeiträumen (Anke und Risch 1979, Anke und Müller 2011, Anke et al 2002, Frank 2001, Murase et al 2012, Coenen 2016 …”

“…Literaturberichte über Haaranalysen gibt es weiterhin zur Prü-fung der Versorgungslage , Emara et al 2013) und von Standorteinflüssen , Shao und Zheng 2008, zu Selenintoxikationen (Witte et al 1992, Coenen et al 1998, Davis et al 2014, zu Arzneimittelanwendungen (Cape und Hinz 1982, Dunnett und Lees 2003, zur Bewertung organischer und anorganischer Supplemente (Kania et al 2009), zur Verträg-lichkeit kontaminierter Weiden (Madejón et al 2009(Madejón et al , 2012 sowie zum Status bei Krankheiten, wie dem AV-Block (Asano et al 2006, Suzuki et al 2007, Murase et al 2012. So konnte man z.…”