Serum zinc level in depressed patients during zinc supplementation of imipramine treatment

Siwek, Marcin; Dudek, Dominika; Schlegel-Zawadzka, Małgorzata; Morawska, Agnieszka; Piekoszewski, Wojciech; Opoka, Włodzimierz; Zięba, Andrzej; Pilc, Andrzej; Popik, Piotr; Nowak, Gabriel

doi:10.1016/j.jad.2010.04.024

Cited by 108 publications

(85 citation statements)

References 32 publications

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“…Probably, decreased glucocorticoid levels inhibit excitation-induced glutamate and this may also explain the normalization of serum zinc concentration after each antidepressant. Normalization of zinc after successful antidepressant treatment was also observed in the clinical study [24,46]. In the research, the patients' non-response to conventional antidepressants showed a lower concentration of zinc (by 14%).…”

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 64%

“…TRD patients receiving zinc supplementation (to antidepressant therapy) significantly reduced depression scores, which suggests a link between drug resistance and disturbances in glutamatergic transmission [45]. Low serum zinc concentration was proposed as a state marker of depression (particularly treatment resistant) [26,46]. Our research shows that a zinc deficient diet alters the efficacy of antidepressants.…”

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 64%

“…An association between low zinc status and high depression scores has also been observed [24,37,70]. Additionally, it was found that lower serum zinc level might be normalized after successful antidepressant treatment [26,29,46]. There are also clinical data suggesting that zinc supplementation may enhance antidepressant therapy in patients with unipolar depression, particularly in those previously nonresponsive [34,45].…”

Section: Introductionmentioning

confidence: 91%

“…Clinical studies have demonstrated that not only do depressed patients exhibit significantly lower serum zinc levels than the control subjects, but also that treatment-resistant patients display lower serum zinc concentration than those responsive to drug therapy [24,26,29,46]. An association between low zinc status and high depression scores has also been observed [24,37,70].…”

Section: Introductionmentioning

confidence: 99%

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Zinc deficiency alters responsiveness to antidepressant drugs in mice

Młyniec

Budziszewska

Reczyński

et al. 2013

Pharmacological Reports

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Abstract:Background: There is some evidence coming from preclinical and clinical studies suggesting a relationship between dietary zinc intake and depressive symptoms. The aim of the study was to determine whether zinc deficiency alters the response to antidepressants with a different mechanism of action. We examine also whether these changes are related to activity of the hypothalamic-pituitaryadrenal HPA axis. Methods: Male CD-1 mice were assigned to groups according to diet and antidepressant administration. To evaluate animal behavior, the immobility time in the forced swim test (FST) and locomotor activity were measured. To determine serum zinc levels the flame atomic absorption spectroscopy (FAAS) was used. The serum corticosterone was determined by radioimmunoassay (RIA). Results: Antidepressants administered to zinc-deprived mice induced an altered response in the FST when compared to animals fed with an adequate diet. There were no changes in locomotor activity. Animals subjected to a zinc-deficient diet showed a significant reduction in serum zinc levels, which was normalized by antidepressant treatment. An increase in serum corticosterone concentrations in mice fed with a zinc-deficient diet and treated with antidepressants was observed, so it can be concluded that reduced levels of zinc contribute hyperactivation of the HPA axis. Conclusion:The results of this study suggest that a diet with a reduced zinc level alters antidepressant action, which is associated with a reduction in the serum zinc level and rise in the corticosterone level. The results of this study may indicate the involvement of zinc deficiency in the pathogenesis of depression.

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Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 64%

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Młyniec

Budziszewska

Reczyński

et al. 2013

Pharmacological Reports

Self Cite

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“…Therefore, this parameter can be used to distinguish TRD from the classic forms of depression (Stefanescu & Ciobica 2012). Another experiment suggests that patients with TRD depression are characterized by low Zn2+ concentrations in serum (Siwek et al 2010 The patients who were additionally given the ethyl ester of eicosapentaenoic acid (E-EPA) were characterized by a lower mean score on the Hamilton scale as compared to the patients in the placebo group (treated with antidepressants and placebo) (Nemets et al 2002).…”

Section: Disorders Of Biochemical Pathways In the Diagnosis And Antidmentioning

confidence: 99%

Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders

et al. 2017

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Zinc in the central nervous system: From molecules to behavior

2012

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The trace metal zinc is a biofactor that plays essential roles in the central nervous system across the lifespan from early neonatal brain development through the maintenance of brain function in adults. At the molecular level, zinc regulates gene expression through transcription factor activity and is responsible for the activity of dozens of key enzymes in neuronal metabolism. At the cellular level, zinc is a modulator of synaptic activity and neuronal plasticity in both development and adulthood. Given these key roles, it is not surprising that alterations in brain zinc status have been implicated in a wide array of neurological disorders including impaired brain development, neurodegenerative disorders such as Alzheimer’s disease, and mood disorders including depression. Zinc has also been implicated in neuronal damage associated with traumatic brain injury, stroke, and seizure. Understanding the mechanisms that control brain zinc homeostasis is thus critical to the development of preventive and treatment strategies for these and other neurological disorders.

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Serum zinc level in depressed patients during zinc supplementation of imipramine treatment

Cited by 108 publications

References 32 publications

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders

Zinc in the central nervous system: From molecules to behavior

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