Serum Zinc, Iron and Copper Concentrations in Dogs Infected with Hepatozoon canis

Seyrek, Kamil; Karagenç, Tülin; Paşa, Serdar; Kiral, Funda; Atasoy, Abidin

doi:10.2754/avb200978030471

Cited by 13 publications

(9 citation statements)

References 26 publications

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“…Furthermore, our recorded corroborate the opinion of (32) who reported that Hepatozoon canis caused an increased in serum Cu level and a decreased in Zn level. Contrary to our results, Seyrek et al (32) mentioned that serum Fe decreased in dog infected with H. canis. Many factors have been explained to reduce the level of Zn in the serum of animal including indirect effect of the host-parasite relationship or increased Zn demand by the parasite itself (33), and hormonal changes (34).…”

Section: Trace Elements Estimationcontrasting

confidence: 99%

Estimation of some biochemical parameters and trace elements in sheep infested with Taenia hydatigena cysts in Sulaymaniyah province/Iraq

Mohammed¹,

Kadir²

2020

IJVS

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This study was carried out in Sulaymaniyah province, Iraq to estimate the concentration of some biochemical parameters and trace elements in the serum of sheep infected with the metacestodes of Taenia hydatigena. The present study included the measurement of some biochemical parameters as total protein, albumin and globulin and evaluation of trace elements as zinc, copper and iron using automatic analyzer and spectrophotometer respectively. For this purpose, up to 40 serum samples from sheep infected with T. hydatigena cysts and 10 serum samples from non-infected group had been used. The findings of the current study showed significant elevated levels in both total protein and globulin compared to non-infected group, where the total protein and globulin levels were 8.04 ± 0.275 g/dl and 5.90 ± 0.321 g/dl respectively, compared to the non-infected group 6.686 ± 0.409 g/dl and 4.124 ± 0.479 g/dl respectively. While, the mean serum albumin in infected sheep was significantly decreased 2.14 ± 0.224 g/dl compared to non-infected one 2.562 ± 0.152 g/dl. About the results of trace elements, the serum Cu was significantly increased in infected group 1.42 ± 0.466 mg/L compared to non-infected one 0.90 ± 0.171 mg/L, while the mean serum Zn concentration was significantly decreased in infected group 0.37 ± 0.230 mg/L compared to non-infected group 0.70 ± 0.108 mg/L. Although, the mean serum Fe of infected sheep 1.42 ± 0.388 mg/L was slightly lower than noninfected one 1.26 ± 0.490 mg/L, statistically there was no significant difference between them. It was concluded that T. hydatigena cysts had significant effects on serum total protein, globulin, Zn and Cu.

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Section: Trace Elements Estimationcontrasting

confidence: 99%

Estimation of some biochemical parameters and trace elements in sheep infested with Taenia hydatigena cysts in Sulaymaniyah province/Iraq

Mohammed¹,

Kadir²

2020

IJVS

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“…Serum copper concentrations are also higher in human patients suffering from hepatic disorders [ 31 ], and elevated Cu:Zn ratios have been proposed as markers of disease in patients with hepatic cirrhosis [ 31 ] or hepatocellular carcinoma [ 32 ]. The role of Cu in the acute-phase protein ceruloplasmin in controlling acute inflammatory-infectious disorders, leading to a marked increase in Cu serum concentrations, is well known in both dogs [ 22 , 33 ] and humans [ 34 ]. There is evidence of increased concentrations of Cu and decreased concentrations of Fe and Zn in serum of dogs infected with Hepatozoon canis [ 22 ] and with Rangelia vitalii (Apicomplexa: Piroplasmorida) [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…The role of Cu in the acute-phase protein ceruloplasmin in controlling acute inflammatory-infectious disorders, leading to a marked increase in Cu serum concentrations, is well known in both dogs [ 22 , 33 ] and humans [ 34 ]. There is evidence of increased concentrations of Cu and decreased concentrations of Fe and Zn in serum of dogs infected with Hepatozoon canis [ 22 ] and with Rangelia vitalii (Apicomplexa: Piroplasmorida) [ 33 ]. The concentrations of Cu in human serum are increased in various carcinomas [ 32 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Concentrations of Essential Trace and Toxic Elements in Healthy and Disease-Affected Dogs

Cedeño

Miranda

Galdo

et al. 2020

Animals

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This study was designed (i) to establish reference ranges for the essential trace element and background levels of toxic element exposure in the healthy/normal dog population, and (ii) to evaluate whether trace element concentrations vary in dogs suffering from different pathologies. Blood serum samples were collected from 187 healthy and diseased dogs at the Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Santiago de Compostela (northwest Spain). The samples were acid digested, and the concentrations of trace elements (Co, Cr, Cu, Fe, Mn, Mo, Ni, Se and Zn) and toxic elements (As, Cd, Hg and Pb) were determined by inductively coupled plasma-mass spectrometry (ICP-MS). This enabled us to establish reference ranges for the essential trace elements and the level of toxic element exposure in dogs, and to identify several clinical situations associated with variations in trace elements in serum. Relative to concentrations in healthy control dogs, statistically significant differences were observed in the concentrations of Cu (significantly higher in hepatic, inflammatory/infectious and oncological categories), Mo (significantly higher in renal category), Se (significantly lower in gastrointestinal category) and Zn (significantly lower in gastrointestinal, inflammatory/infectious and renal categories). Trace element concentrations can be a cause or consequence of disease, and the study findings indicate that trace element determination in serum provides useful information on the pathogenesis of certain diseases. Further research on the serum concentrations of trace elements, particularly in relation to other biochemical parameters and diagnostic tools, may provide valuable information for the diagnosis of diseases in dogs and the disease prognosis.

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“…To the author's knowledge, report on the levels of these minerals in dogs with CME or any other rickettsial disease is lacking to compare the present findings. However, low levels of Zn and Cu have been reported in case of other tick-borne diseases like Babesia gibsoni [42] and Hepatozoon canis [43] in dogs.…”

Section: Plasma Hormonal and Blood Mineral Profile Of Affected Animalsmentioning

confidence: 99%

Molecular Detection and Assessment of Hemato-Biochemistry, Oxidant/Antioxidant Status in Natural Canine Monocytic Ehrlichiosis Cases from Northern India

Behera¹,

Dimri

Banerjee

et al. 2015

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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The present study was aimed at detecting natural cases of canine monocytic ehrlichiosis (CME) by molecular and cytological methods and assessment of clinico-patho-biochemical parameters among the affected population. Nested polymerase chain reaction was found to be highly sensitive (47.7 %) in detecting the acute cases, followed by buffy coat (29.5 %) and blood smear examination (22.7 %). CME incidence rate was found to be 8.4 %. Hemogram revealed significant (P \ 0.01) depletion in the levels of hemoglobin, hematocrit, total erythrocyte count, monocyte and platelet count in diseased dogs as compared to healthy controls. Plasma biochemistry revealed hypoproteinemia, hypoalbuminemia and hyperglobulinemia along with significantly (P \ 0.05) higher blood urea nitrogen and alanine aminotransferase values. CME revealed non-significant increase in the levels of erythrocytic lipid peroxides, reduced glutathione and activity of superoxide dismutase, whereas activities of glutathione-S-transferase and glutathione reductase showed significant (P \ 0.05) increase and decrease, respectively as compared to healthy controls. Plasma levels of cortisol, insulin and blood level of copper showed non-significant (P [ 0.05) reduction, whereas blood level of zinc showed significant (P \ 0.05) reduction as compared to healthy controls. These findings revealed that changes in erythrocytic oxidant-antioxidant profile and blood mineral concentration in canine monocytic ehrlichiosis are largely nonsignificant and inconsistent. Hence, further study is required to elucidate their role in pathogenesis of canine monocytic ehrlichiosis.

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Serum Zinc, Iron and Copper Concentrations in Dogs Infected with Hepatozoon canis

Cited by 13 publications

References 26 publications

Estimation of some biochemical parameters and trace elements in sheep infested with Taenia hydatigena cysts in Sulaymaniyah province/Iraq

Estimation of some biochemical parameters and trace elements in sheep infested with Taenia hydatigena cysts in Sulaymaniyah province/Iraq

Serum Concentrations of Essential Trace and Toxic Elements in Healthy and Disease-Affected Dogs

Molecular Detection and Assessment of Hemato-Biochemistry, Oxidant/Antioxidant Status in Natural Canine Monocytic Ehrlichiosis Cases from Northern India

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