Serum zinc deficiency in patients after gastrectomy for gastric cancer

Namikawa, Tsutomu; Shimizu, Shigeto; Yokota, Keiichiro; Tanioka, Nobuhisa; Iwabu, Jun; Munekage, Masaya; Uemura, Sunao; Maeda, Hiromichi; Kitagawa, Hiroyuki; Kobayashi, Mariko; Hanazaki, Kazuhiro

doi:10.1007/s10147-021-01978-w

Cited by 12 publications

(10 citation statements)

References 29 publications

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“…Although limited information indicates that zinc status is associated with gastric cancer, a recent study showed that serum zinc de ciency was found in 68.6% of 617 postoperative patients who underwent gastrectomy for gastric cancer [5]. Furthermore, Hagi et al reported that patients with a decreased sweet sensitivity had lower serum zinc concentrations than those without it in a study of the postoperative evaluation of 243 patients with gastric cancer, while symptoms of zinc de ciency varied depending on its severity [20].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies demonstrated a statistical correlation between zinc and albumin in both healthy participants or patients who underwent gastrectomy for gastric cancer [5,27]. The majority of plasma zinc is bound to serum albumin because serum albumin acts as a transport protein, and it has been reported that preoperative and post-gastrectomy malnutrition were associated with poor long-term survival [28,29].…”

Section: Discussionmentioning

confidence: 99%

“…Excessive accumulation or depletion of trace elements may have signi cant clinical implications, including increased risk for cancer, cardiovascular disease, immune de ciency, anemia, renal function impairment, and bone disease [4]. Among the trace elements in the human body, zinc is the second most abundant, after iron only [5]. Zinc is an essential trace element for numerous biological processes including immune function, cell differentiation, and cell replication [6].…”

Section: Introductionmentioning

confidence: 99%

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Association between serum zinc levels and clinicopathological characteristics in patients with gastric cancer

Namikawa

Utsunomiya

Yokota

et al. 2022

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Purpose This study aimed to evaluate the association between clinicopathologic features and serum zinc levels in preoperative patients with gastric cancer. Methods The study enrolled 83 patients scheduled for gastric cancer surgery at the Kochi Medical School. Clinical data were obtained to investigate associations between clinicopathological features, including nutritional indicators and serum zinc levels. Serum zinc deficiency was defined as serum zinc level < 80 µg/dL. Results The median zinc level of the 83 patients was 73 µg/dL (range, 20–152 µg/dL), and serum zinc deficiency was present in 66.3% of patients. Albumin was significantly lower in the zinc low level group than in the normal group (3.9 g/dL vs. 4.4 g/dL, P < 0.001), and the median serum zinc level was significantly lower in the albumin < 4.1 g/dL group than in the albumin ≥ 4.1 g/dL group (69 µg/dL vs. 82 µg/dL, P < 0.001). Lymphocyte count was significantly lower in the zinc low level group than in the normal group (1500 vs. 1810 years, P = 0.041). The median serum zinc level was significantly lower in the age ≥ 74 group than in the age < 74 (71 µg/dL vs. 76 µg/dL, P = 0.002). Serum zinc levels showed a significant positive correlation with serum albumin (r = 0.637, P = 0.009). Conclusions Serum zinc deficiency was found in 66.3% of preoperative patients with gastric cancer, which was highly correlated with serum albumin.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between serum zinc levels and clinicopathological characteristics in patients with gastric cancer

Namikawa

Utsunomiya

Yokota

et al. 2022

Preprint

Self Cite

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“…Gastrectomy leads to the occurrence of nutritional deficiencies. The frequency of diagnosing zinc deficiencies in patients after gastrectomy varies from 10 to 75% [27]. Gastric resection with Roux-en-Y reconstruction may increase the risk of fat-soluble vitamin deficiencies -A, D, E, K [28].…”

Section: Nutritional Problems Of Patients After Gastrectomymentioning

confidence: 99%

Nutritional problems of patients after gastrectomy and the risk of developing malnutrition

Grochowska,

Gazi,

Surwiłło-Snarska

et al. 2024

Nowotwory. Journal of Oncology

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The radical treatment for advanced gastric cancer is gastrectomy. This procedure disrupts the anatomy and physiology of the gastrointestinal tract. After surgery, nausea, heartburn, biliary regurgitation, feeling of early satiety, belching, lack of appetite, and swallowing problems are reported to affect food intake.Decreased absorption, loss of nutrients, and increased energy requirements of cancer patients lead to weight loss and the development of malnutrition. After gastrectomy, the composition of the intestinal microbiome changes, the exocrine activity of the pancreas decreases, and deficiency-metabolic disorders (including iron, vitamin B 12 , zinc, and vitamin D) develop. Approximately 60-70% of gastrectomy patients experience clinically significant deterioration in quality of life. Nutritional management should include dietary modification, appropriate nutritional supplementation and close monitoring of the nutritional status of these patients.

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“…Fluctuations in serum zinc levels in chronic liver and chronic kidney disease are known (8). However, there are a few reports on the fluctuations in serum zinc levels during perioperative gastrointestinal surgery and malignant diseases (9).…”

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confidence: 99%

Significance of Zinc Replacement Therapy After Pancreaticoduodenectomy

et al. 2022

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Background/Aim: Recently, a decrease in serum zinc levels and the need for zinc preparations have been reported in the perioperative period of gastrointestinal surgery. In this study, we examined treatment outcomes among patients supplemented with zinc after pancreaticoduodenectomy (PD) and evaluated the significance of zinc replacement therapy. Patients and Methods: From June 2020 to April 2021, 56 patients who received zinc acetate hydrate (50 mg/day) from postoperative day 3 after PD in our department were retrospectively reviewed. Patients' characteristics and preoperative as well as postoperative data, including serum zinc levels and surgical results at 1 month were reviewed. Results: Preoperative zinc deficiency was present in 86.1% (46/56) of the patients. Moreover, despite zinc supplementation, 17.8% (10/56) of patients had postoperative zinc deficiency. A comparison between the low zinc level group (Zn <80 μg/dl) and the normal zinc level group (Zn ≥80 μg/dl) after surgery showed siginificant differences among patients with malignant diseases (vs. benign diseases, p=0.044), those undergoing open surgery (vs. minimally invasive surgery, p=0.036), and those with intraoperative blood loss ≥346 ml (vs. <346 ml: p=0.041) in the univariate analysis. Multivariate analysis revealed that zinc deficiency was significantly associated with open surgery [odds ratio (OR)=15.885, 95% confidence interval (CI)=1. 77-142.01, p=0.013] and intraoperative blood loss (OR=9.329, p=0.016). Conclusion: In patients undergoing open PD for pancreatic cancer, zinc preparations of 50 mg may not be sufficient and further supplementation may be necessary.

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Serum zinc deficiency in patients after gastrectomy for gastric cancer

Cited by 12 publications

References 29 publications

Association between serum zinc levels and clinicopathological characteristics in patients with gastric cancer

Association between serum zinc levels and clinicopathological characteristics in patients with gastric cancer

Nutritional problems of patients after gastrectomy and the risk of developing malnutrition

Significance of Zinc Replacement Therapy After Pancreaticoduodenectomy

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