Serum zinc and serum lipid profiles in 778 adults

Hiller, Rita; Seigel, Daniel; Sperduto, Robert D.; Blair, Norman P.; Burton, Thomas C.; Farber, Marilyn D.; Gragoudas, Evangelos S.; Gunter, Elaine W.; Haller, Julia A.; Seddon, Johanna M.; Sowell, Anne L.; Yannuzzi, Lawrence A.

doi:10.1016/1047-2797(95)00066-6

Cited by 28 publications

(17 citation statements)

References 39 publications

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“…According to our data, a similar sex-dependent effect of Zn on TAG level was also reported in the SU.VI.MAX study with a multi-nutrient antioxidant supplementation containing 20 mg Zn (Hercberg et al 2005). Moreover, we did not report a negative effect of Zn supplementation on HDL status, consistent with the results of some (Crouse et al 1984;Fosmire, 1990;Hiller et al 1995;Bonham et al 2003;Hercberg et al 2005) but not all (Hooper et al 1980;Chandra, 1984;Chevalier et al 2002) studies. It seems that these results depend on the studied Zn intake, in particular when it is excessive, since in these studies, the adverse effects on HDL were described for pharmacological Zn supplementation at 50 mg/d (Black et al 1988;Chevalier et al 2002) or higher; 75 mg/d (Black et al 1988); 300 mg/d (Chandra et al 1984); 440 mg/d (Hooper et al 1980).…”

Section: Discussionsupporting

confidence: 92%

Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study

et al. 2007

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Given the key role of Zn in many physiological functions, optimal Zn status could be a predictive parameter of successful ageing. However, the benefit of Zn supplementation is still a matter of debate since Zn supplementation has been reported to be associated with the alteration of Cu status and lipid metabolism. As part of the Zenith Project, the present study aimed to investigate, in free-living healthy European middle-aged and older subjects, the effect of Zn supplementation on the biochemical status of Zn, Fe and Cu and on lipid profile. Volunteers aged 55 -70 (n 188) and 70-85 (n 199) years old participated in a double-blinded, randomised study and received a daily placebo, or Zn as 15 or 30 mg for 6 months. Zn supplementation did not significantly modify erythrocyte Zn levels or erythrocyte Cu,Zn-superoxide dismutase activity. But Zn supplementation at 15 or 30 mg/d for 6 months increased significantly serum Zn levels and Zn urinary excretion with no major adverse effects on Fe and Cu status or on lipid metabolism. However, Zn supplementation at 30 mg/d showed some age-and sex-dependent alterations in Fe status or lipid profile. Therefore, with respect to the key role of an optimal Zn status in successful ageing, Zn supplementation at 15 mg/d, when necessary, could be safely proposed regarding lipids and the risk of interaction with Fe and Cu.Zinc supplementation: Zinc status: Trace element interactions: Trace element -lipid interactions: Elderly

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Section: Discussionsupporting

confidence: 92%

Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study

et al. 2007

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“…These results for iron consumption and their effect of plasma triglycerides were confirmed by various researchers [29] who observed that increasing dietary iron did not affect triglyceride concentration. On the other hand, other studies have demonstrated that higher zinc serum level were associated with higher serum triglyceride [24]. Contrarily, in the present study, zinc as ZnO or ZnSO 4 did not demonstrate such effects which might be attributed to numerous reasons like the fortificants vehicle, animal breed, and environmental factors.…”

Section: Triglyceridescontrasting

confidence: 79%

“…Serum zinc association with cholesterol has been widely reported, demonstrating serum zinc to be positively related to the total cholesterol and higher serum zinc level, most notably, those above the highest quintile were associated with higher levels of total serum cholesterol [24,25]. The current study suggested that concentration of zinc is directly associated with the plasma cholesterol concentration in rats.…”

Section: Resultsmentioning

confidence: 55%

Effect of Mineral Fortification on Plasma Biochemical Profile in Rats

Akhtar

Anjum

Rehman

et al. 2011

Biol Trace Elem Res

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This study aimed at investigating the changes in biochemical profile of male rats following 8 weeks administration of different concentration of elemental iron, sodium iron ethylenediaminetetraacetate (NaFeEDTA), zinc sulfate (ZnSO(4)), and zinc oxide (ZnO) in whole wheat flour. Eight groups comprising five rats each were fed fortified whole wheat flour in the form of baked pallets, while one group served as control. Concentration of total cholesterol, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), triglycerides, total proteins, albumin, globulin, plasma glucose, and blood urea nitrogen were assayed. Supplementing mineral-fortified diet to male rats did not indicate any significant (p ≤ 0.05) effect on total cholesterol concentration. Diets containing NaFeEDTA alone increased HDL-C and decreased LDL-C; however, the differences remained non significant. Likewise, plasma triglycerides content of male rats remained unchanged on feeding fortified diets. Diets containing iron as NaFeEDTA and elemental iron exerted little effect on total protein concentration in the plasma of rats. Plasma glucose and blood urea nitrogen levels did not exhibit any significant change as a result of ingesting mineral supplemented diets. The study concludes that the forms of fortificants and the fortification levels used in the current study are undamaging for lipid profile, renal function, and glucose levels in rats, suggesting that these may be safely used in wheat flour to combat iron and zinc deficiency in vulnerable groups.

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“…Individuals, who use high-dose zinc supplementation as a potential treatment for agerelated macular degeneration, will have higher exposures to zinc. Hiller et al (1995) reported that zinc supplements will have an effect on the concentration of serum zinc in the body.…”

Section: Populations With Potentially High Exposuresmentioning

confidence: 99%

Toxicological Profile for Zinc

2002

ATSDR's Toxicological Profiles

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Serum zinc and serum lipid profiles in 778 adults

Cited by 28 publications

References 39 publications

Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study

Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study

Effect of Mineral Fortification on Plasma Biochemical Profile in Rats

Toxicological Profile for Zinc

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