Serum YKL-40 levels as a prognostic factor in patients with intracerebral hemorrhage

Jiang, Yi-Xiang; Zhang, Guihong; Wang, Zhimin; Yang, Hui

doi:10.1016/j.clinbiochem.2014.09.015

Cited by 19 publications

(12 citation statements)

References 41 publications

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“…[19][20][21] Currently, YKL-40 is not only associated with pulmonary diseases, but also considered to be an independent biomarker of cardiovascular and cerebrovascular diseases, such as carotid artery atherosclerosis, myocardial infarction, ischemic stroke, spontaneous subarachnoid hemorrhage and intracerebral hemorrhage. [10][11][12]22 Park et al reported that YKL-40 levels might be associated with stroke severity, infarct volume and clinical outcome of 105 Korean AIS patients. 10 However, this is a small-size study without prospective information.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 Recently, in terms of diagnosis and prognosis, YKL-40 has been proposed as a useful and meaningful biomarker for cerebrovascular diseases, such as ischemic stroke, spontaneous subarachnoid hemorrhage as well as intracerebral hemorrhage. [10][11][12] Nevertheless, whether levels of YKL-40 are correlated with SAP remains unclear and wait for neurologists to explore.…”

Section: Introductionmentioning

confidence: 99%

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The Relationship Between Serum YKL-40 Levels on Admission and Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke

Shi

Chen

Gong

et al. 2021

JIR

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Background Stroke-associated pneumonia (SAP) is a standout complication after acute ischemic stroke (AIS), with a prevalence of 7–38%. The aim of this prospective study was to investigate the relationship between serum YKL-40 levels at admission and SAP. Methods Between August 2020 and February 2021, consecutive AIS patients from two centers were enrolled prospectively. Serum YKL-40 concentrations were measured via enzyme-linked immunosorbent assay. We performed logistic regression analyses to explore the relationship between YKL-40 and SAP. Receiver operating characteristic curve was also used to assess the predictive ability of YKL-40 in predicting SAP. Results Ultimately, a total of 511 AIS patients were recruited. Multivariate logistic regression analysis showed that YKL-40 was independently related to SAP, whether as a continuous variable or as quartiles ( P =0.001). The area under curve of YKL-40 to predict SAP was 0.765. The optimal cutoff value of YKL-40 as a predictor of SAP was determined to be 206.4 ng/mL, where the sensitivity was 63.1% and the specificity was 82.0%. Conclusion Our study demonstrated that YKL-40 might be considered as a useful biomarker to predict SAP in AIS patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Relationship Between Serum YKL-40 Levels on Admission and Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke

Shi

Chen

Gong

et al. 2021

JIR

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“…The predictive utility of WBC count alone was investigated in 3 different studies but was not significantly associated with long-term functional outcomes in two of the studies. 32,22 Other inflammatory biomarkers predicting long-term functional outcome in ICH include CRP, 32,33 S100A12, 34 CD163, 35 sCD40 L, 36 YKL-40, 37 and Gelsolin (Table 2). 37,38 Although inflammatory markers are non-neuron-specific, their substantiated predictive utility warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…32,22 Other inflammatory biomarkers predicting long-term functional outcome in ICH include CRP, 32,33 S100A12, 34 CD163, 35 sCD40 L, 36 YKL-40, 37 and Gelsolin (Table 2). 37,38 Although inflammatory markers are non-neuron-specific, their substantiated predictive utility warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Utility of Serum Biomarkers in Intracerebral Hemorrhage: A Systematic Review

Troiani

Ascanio

Rossitto

et al. 2021

Neurorehabil Neural Repair

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Background. Intracerebral hemorrhage (ICH) accounts for 10–20% of all strokes and is associated with high morbidity and mortality. Recent studies have identified serum biomarkers as a means to improve outcome prognostication in poor grade ICH patients. Poor prognosis of ICH patients and complex pathophysiology of the disease necessitate prognostic serum biomarkers to help guide treatment recommendations. Objective. The objective is to systematically review all biomarkers used to predict long-term functional outcome in patients with spontaneous intracerebral hemorrhage. Results. We identified 36 studies investigating the predictive utility of 50 discrete biomarkers. Data from 4865 ICH patients were reviewed. Inflammatory biomarkers (11/50) were most often studied, followed by oxidative (8/50), then neuron and astrocyte-specific (7/50). S100 calcium binding protein B, white blood cell count, and copeptin were the most often studied individual biomarkers. The prognostic utility of 23 biomarkers was analyzed using receiver operating characteristic curves. Area under the curve (AUC) values for all available biomarkers except neutrophil/lymphocyte ratio were acceptable. Twenty of the 23 biomarkers were characterized by at least one excellent AUC value. Vascular endothelial growth factor, glial fibrillary astrocyte protein, and S100 calcium binding protein B were characterized by outstanding AUC. Conclusions. We identified the inflammatory and neuron and astrocyte-specific biomarker categories as having the greatest number of significant individual biomarker predictors of long-term outcome. Further investigation utilizing cross-validation of prediction models in a second independent group and blinded assessment of outcomes for the predictive utility of biomarkers in patients with ICH is warranted.

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“…According to Park et al , serum YKL‐40 levels associate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients. Jiang et al observed that YKL‐40 is associated with inflammation and severity of intracerebral hemorrhage, and may independently predict long‐term clinical outcomes of intracerebral hemorrhage. Thus, YKL‐40 may be a predictor of functional outcome in patients with cerebrovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Effect of carotid endarterectomy on brain damage markers

et al. 2016

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Data from our study showed that CEA affects serum YKL-40 but not NEFL and FABP7 levels. This implicates that YKL-40 may be a valuable serum marker of brain damage after CEA. However, the observed change in serum YKL-40 level in patients after CEA does not necessarily warrant a change in recommendations concerning the use of this treatment in patients with high-grade internal carotid artery stenosis.

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Serum YKL-40 levels as a prognostic factor in patients with intracerebral hemorrhage

Cited by 19 publications

References 41 publications

The Relationship Between Serum YKL-40 Levels on Admission and Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke

The Relationship Between Serum YKL-40 Levels on Admission and Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke

Prognostic Utility of Serum Biomarkers in Intracerebral Hemorrhage: A Systematic Review

Effect of carotid endarterectomy on brain damage markers

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