Serum YKL-40: A new potential marker of prognosis and location of métastases of patients with recurrent breast cancer

Johansen, Julia S.; Cintin, C.; Jørgensen, Morten; Kamby, Claus; Price, Paul A.

doi:10.1016/0959-8049(95)00196-p

Cited by 135 publications

(136 citation statements)

References 17 publications

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“…It was first isolated from porcine VSMC, which is highly induced during nodule formation, but the precise function of this gene is presently unknown. High serum expression of YKL-40 has been associated with poor prognosis in colorectal cancer (Cintin et al, 1999), glioblastoma multiforme (Tanwar et al, 2002), breast cancer (Johansen et al, 1995), ovarian cancer (Dehn et al, 2003), and lung cancer (Johansen et al, 2004). Consistent with the function of CLU, overexpression of YKL-40 has been implicated in increased migration and tissue remodeling.…”

Section: Discussionmentioning

confidence: 99%

Clusterin plays an important role in hepatocellular carcinoma metastasis

et al. 2005

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To identify genes associated with tumor metastasis in hepatocellular carcinoma (HCC), gene expression profiles between a pair of primary HCC (H2-P) and their matched metastatic HCC (H2-M) were compared. Overexpression of clusterin (CLU) was found in H2-M cells. To determine the roles CLU played in HCC metastasis, CLU was transfected into H2-P cells. Overexpression of CLU in H2-P cells increased cell migration by twofold in vitro and formation of metastatic tumor nodules in liver by eightfold in vivo. To evaluate the correlation of CLU expression with HCC metastasis, the expression levels of CLU in HCCs were investigated using a tissue microarray (TMA) containing 104 pairs of primary HCCs and their matched metastases. The frequency of CLU overexpression increased significantly in metastatic HCCs (59.1%) compared with that in primary tumors (32.6%, Po0.001). To gain additional insight into the function of CLU, the expression profile of H2P-CLU was compared with vector-transfected H2-P cells by cDNA microarray. A total of 35 upregulated and 14 downregulated genes were detected in H2P-CLU. One of the upregulated genes known as YKL-40, which is implicated in matrix-remodeling and metastasis, was further studied using TMA. A significant correlation (Po0.001) between the expression levels of YKL-40 and CLU was observed, implying that the CLU-YKL-40 pathway may play an important role in HCC metastasis.

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Section: Discussionmentioning

confidence: 99%

Clusterin plays an important role in hepatocellular carcinoma metastasis

et al. 2005

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“…For example, hypoglycemia (7 ) or physical exercise (8 ) are potent physiologic stressors, whereas fear (9 ), feelings of inferiority (10,11 ), or experiences at school (12,13 ) can affect the adrenal cortex activity as psychologic stressors. The taking of blood can also influence adrenal steroid concentrations in children; saliva collection, however, is almost stress-free (14 ).…”

Section: Ykl-40 As a Marker Of Joint Involvement Inmentioning

confidence: 99%

“…Spondyloarthropathy, diagnosed on the Clinical Chemistry 49, No. 10,2003 basis of clinical and radiologic findings, was classified according to the European Spondyloarthropathy Study Group system. All patients were given mesalazin (1800 mg daily) or sulfasalazin (3-4 g daily); none were treated with corticosteroids.…”

Section: Ykl-40 As a Marker Of Joint Involvement Inmentioning

confidence: 99%

YKL-40 as a Marker of Joint Involvement in Inflammatory Bowel Disease

et al. 2003

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“…Recently, we reported that increased levels of YKL-40 in serum are found in patients with metastatic breast carcinoma 21 and in patients with all stages of colorectal carcinoma. 22 Like CEA, YKL-40 cannot be used as a single screening test for colorectal carcinoma, since only 26% of patients with colorectal carcinoma have elevated serum YKL-40 levels at the time of operation.…”

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confidence: 99%