Serum vitamin K1 concentrations after oral administrationof vitamin K1 in low birth weight infants

Sann, L; Leclercq, M; Guillaumont, M.; Trouyez, R.; Bethenod, M; Bourgeay-Causse, M

doi:10.1016/s0022-3476(85)80034-2

Cited by 40 publications

(13 citation statements)

References 8 publications

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“…By determining vitamin Ki levels directly through an HPLC method, our no decrease in phylloquinone levels of moth ers tested at the end of pregnancy. In the rat, we noted rapid intestinal absorption of vita min Ki after oral administration: 1-2 h, as already mentioned in previous studies using the rat [16,17], Intestinal absorption by hu mans is slower, both in the child [18] and in the adult [19].…”

Section: Discussionsupporting

confidence: 88%

Vitamin K(1) Diffusion across the Placental Barrier in the Gravid Female Rat

Guillaumont¹,

Durr²,

Combet³

et al. 1988

Dev Pharmacol Ther

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The hemorrhagic disease of the newborn can be prevented by administration of vitamin K(1). The modes of utilization of the vitamin need to be studied in the mother and child. An experimental pharmacokinetic study was conducted, using the gravid female rat. Results showed rapid intestinal absorption of phylloquinone. The fetus plasma concentration rose from 8.6 µg/l at time 0 to 0 to 44.3 µg/l at 8 h. Such an increase is an evidence of phylloquinone diffusion across the placenta. The phenomenon requires a high gradient. On the other hand, maximum plasma concentrations are not reached until the 8th hour.

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Section: Discussionsupporting

confidence: 88%

Vitamin K(1) Diffusion across the Placental Barrier in the Gravid Female Rat

Guillaumont¹,

Durr²,

Combet³

et al. 1988

Dev Pharmacol Ther

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“…Vitamin K prophylaxis has been extensively studied in preterm infants in order to prevent the devastating complications of VKDB [ 120 , 121 , 122 , 123 , 124 , 125 ]. Multiple doses and routes of administration have been investigated, and all of them consistently show a dramatic increase in plasma phylloquinone levels, possibly due in part to the immature hepatic metabolism of vitamin K in premature infants.…”

Section: Fat Soluble Vitaminsmentioning

confidence: 99%

Assessment of Micronutrient Status in Critically Ill Children: Challenges and Opportunities

et al. 2017

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Micronutrients refer to a group of organic vitamins and inorganic trace elements that serve many functions in metabolism. Assessment of micronutrient status in critically ill children is challenging due to many complicating factors, such as evolving metabolic demands, immature organ function, and varying methods of feeding that affect nutritional dietary intake. Determination of micronutrient status, especially in children, usually relies on a combination of biomarkers, with only a few having been established as a gold standard. Almost all micronutrients display a decrease in their serum levels in critically ill children, resulting in an increased risk of deficiency in this setting. While vitamin D deficiency is a well-known phenomenon in critical illness and can predict a higher need for intensive care, serum concentrations of many trace elements such as iron, zinc, and selenium decrease as a result of tissue redistribution in response to systemic inflammation. Despite a decrease in their levels, supplementation of micronutrients during times of severe illness has not demonstrated clear benefits in either survival advantage or reduction of adverse outcomes. For many micronutrients, the lack of large and randomized studies remains a major hindrance to critically evaluating their status and clinical significance.

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“…Some points may be noted: a) An oral dose of vitamin K1 given at birth substantially raised plasma levels, though there were wide individual differences [46,61].…”

Section: ) Vitamin K Prophylaxis A) Classical Hdn Vitamin K Prophylmentioning

confidence: 99%

Vitamin K in infancy

1988

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Vitamin K has regained paediatric interest due to a recurrence of bleeding caused by deficiency of the vitamin in newborns and young infants. Increasing awareness of these clinical problems, the development of new methods for the detection of vitamin K deficiency and the direct measurement of vitamin K in tissues have stimulated research. Much new data obtained from these studies has proved helpful to the understanding of vitamin K deficiency in infancy. For example low concentrations of vitamin K have been found in fetal and neonatal livers. The implications of these findings with respect to manifest vitamin K deficiency and to new methods for detection of subclinical vitamin K deficiency are discussed. Breast-feeding is a major risk factor for classical haemorrhagic disease of the newborn and for late onset bleeding due to vitamin K deficiency in young infants. The interdependencies between breast-feeding and vitamin K deficiency are discussed on the basis of new data obtained from direct measurement of vitamin K in maternal milk. The review further focuses on pathophysiological concepts of bleeding due to vitamin K deficiency in infancy and current concepts of vitamin K prophylaxis.

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Serum vitamin K1 concentrations after oral administrationof vitamin K1 in low birth weight infants

Cited by 40 publications

References 8 publications

Vitamin K(1) Diffusion across the Placental Barrier in the Gravid Female Rat

Vitamin K(1) Diffusion across the Placental Barrier in the Gravid Female Rat

Assessment of Micronutrient Status in Critically Ill Children: Challenges and Opportunities

Vitamin K in infancy

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