Serum Vitamin D Status and Its Relationship to Metabolic Parameters in Patients with Type 2 Diabetes Mellitus

Yu, Jung Re; Lee, Sang Ah; Lee, Jae-Geun; Seong, Gil Myeong; Ko, Seong Joo; Koh, Gwanpyo; Kong, Mihee; Park, Keun‐Young; Kim, Byung-Joon; Lim, Dong Mee; Lee, Dong Hoon

doi:10.4068/cmj.2012.48.2.108

Cited by 38 publications

(41 citation statements)

References 27 publications

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“…Our data are consistent with other studies in the literature that evaluated cardiovascular risk in type 2 diabetes patients from sunny regions [17, 28]. Perhaps lipid levels might be the intervenient variable that explains the link between hypovitaminosis D and cardiovascular disease in patients with type 2 diabetes.…”

Section: Discussionsupporting

confidence: 92%

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Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Rolim¹,

Santos²,

Conceição³

et al. 2016

Diabetol Metab Syndr

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ObjectivesDetermine the prevalence and identify predictors of hypovitaminosis D in patients with type 2 diabetes mellitus (T2DM); 2) correlate vitamin D levels with variables indicative of glycemic control and cardiovascular risk.Research design and methodsWe conducted a cross-sectional study with consecutive patients treated at a University Hospital’s Endocrinology outpatient clinic located at 12°58′S latitude, between October 2012 and November 2013. Hypovitaminosis D was defined as 25-hydroxyvitamin D < 30 ng/mL (chemiluminescence).ResultsWe evaluated 108 patients with mean duration of T2DM of 14.34 ± 8.05 years and HbA1c of 9.2 ± 2.1%. Mean age was 58.29 ± 10.34 years. Most were women (72.2%), non-white (89.8%) and had hypertension (75.9%) and dyslipidemia (76.8%). Mean BMI was 28.01 ± 4.64 kg/m2; 75.9% were overweight. The prevalence of hypovitaminosis D was 62%. In multiple logistic regression, independent predictors of hypovitaminosis D were female gender (OR 3.10, p = 0.02), dyslipidemia (OR 6.50, p < 0.01) and obesity (OR 2.55, p = 0.07). In multiple linear regression, only total cholesterol (β = −0.36, p < 0.01) and BMI (β = −0.21, p = 0.04) remained associated with levels of 25-hydroxyvitamin D.ConclusionsUsing currently recommended cutoffs, the prevalence of hypovitaminosis D in Brazilians with T2DM was as high as that of non-tropical regions. Female gender, dyslipidemia and obesity were predictors of hypovitaminosis D. Low levels of 25-hydroxyvitamin D were correlated with high cholesterol and BMI values. Future studies are needed to evaluate whether vitamin D replacement would improve these parameters and reduce hard cardiovascular outcomes.

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Section: Discussionsupporting

confidence: 92%

“…We found a significant weak negative correlation between HbA1C and 25(OH)D, similar to other previously published studies [12, 18, 23, 28, 33, 34]. However glycemic control was not associated with vitamin D when we controlled for confounding factors, as verified by Luo et al and Al-Shoumer et al [35, 36].…”

Section: Discussionsupporting

confidence: 91%

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Rolim¹,

Santos²,

Conceição³

et al. 2016

Diabetol Metab Syndr

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show abstract

“…A study reported a significant inverse correlation only in diabetic women [8]. However, one study did not find a significant correlation in diabetic patients who were microalbuminuric and with a high cardiovascular risk profile [18]. Other authors failed to find a significant impact on A1C levels in subjects with low concentrations of serum 25(OH)D levels (less than 20 ng/ml) [19].…”

Section: Discussionmentioning

confidence: 99%

Glycated Haemoglobin Is Inversely Related to Serum Vitamin D Levels in Type 2 Diabetic Patients

et al. 2013

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ObjectiveA correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients.Research Design and MethodsWe cross-sectionally examined the association between A1C and serum 25(OH) D in 715 type 2 diabetic patients attending our clinic during the years 2011–2012. The average age was 68±12 years (range 26–94 years). The relation between A1C and serum 25(OH)D levels was modelled by multiple linear regression analyses.ResultsSerum 25(OH)D levels were inversely associated with A1C levels (r = −0.116, p = .003). This relation maintains its independence in the multivariate analysis after adjusting for age, sex, A1C, BMI, treatment and duration of diabetes and nephropathy.ConclusionsIn type 2 diabetic patients, high A1C levels are associated with low concentrations of serum 25(OH)D independently of duration of diabetes, diabetic treatment and nephropathy. Future studies are needed to clarify the biological relation between glucose control and vitamin D metabolism in type 2 diabetes.

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“…1 Vitamin D has established roles in calcium and bone metabolism. It is estimated that about one billion people worldwide have vitamin D deficiency or insufficiency.…”

mentioning

confidence: 99%

Relation of Low Vitamin D to Nonvalvular Persistent Atrial Fibrillation in Chinese Patients

Chen

Liu

Shi

et al. 2013

Noninvasive Electrocardiol

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Serum Vitamin D Status and Its Relationship to Metabolic Parameters in Patients with Type 2 Diabetes Mellitus

Cited by 38 publications

References 27 publications

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Glycated Haemoglobin Is Inversely Related to Serum Vitamin D Levels in Type 2 Diabetic Patients

Relation of Low Vitamin D to Nonvalvular Persistent Atrial Fibrillation in Chinese Patients

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