Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis

Lv, Shi Shi; Wang, Ji Ying; Wang, Xiao Qian; Wang, Yan; Xu, Yong

doi:10.1007/s00404-016-4058-1

Cited by 49 publications

(38 citation statements)

References 40 publications

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“…Compared to women with deficient or insufficient vitamin D status, women with replete vitamin D status had more live births (odds ratio (OR): 1.33; 95% confidence interval (CI): 1.08 to 1.65), more positive pregnancy tests (OR: 1.34; 95% CI: 1.04 to 1.73) and more clinical pregnancies (OR: 1.46; 95% CI: 1.05 to 2.02), whereas there was no association between miscarriage and vitamin D status [ 51 ]. Other meta-analyses on vitamin D status and ART outcomes revealed similar findings [ 52 , 53 ]. Vitamin D RCTs specifically designed to assess outcomes of ART are, however, still missing.…”

Section: Fertilitysupporting

confidence: 64%

The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data

Pilz

Zittermann

Obeid

et al. 2018

IJERPH

130

110

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Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the “active vitamin D hormone” calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation.

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Section: Fertilitysupporting

confidence: 64%

The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data

Pilz

Zittermann

Obeid

et al. 2018

IJERPH

130

110

View full text Add to dashboard Cite

show abstract

“…Moreover, previous RCTs have found that supplementation with vitamins C and E (without folic acid) during pregnancy has no protective effect on preeclampsia [ 37 , 38 ]. Lv et al also demonstrated that the risk for lower clinical pregnancy rate was not significantly correlated with deficient serum vitamin D level in infertile woman undergoing in vitro fertilization [ 39 ]. In addition to several studies that have confirmed a relationship between decreased preeclampsia risk and the supplementation of multivitamins containing folic acid [ 13 , 14 ], we speculate that other vitamins may also play some roles in the prevention of preeclampsia, and the key roles of folic acid in preventing the risk of preeclampsia may be enhanced by other nutrients present in multivitamins.…”

Section: Discussionmentioning

confidence: 99%

Supplementation of folic acid in pregnancy and the risk of preeclampsia and gestational hypertension: a meta-analysis

Liu

Wang

Zhang

2018

Arch Gynecol Obstet

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ObjectivesWe aimed to systematically assess the relationship between folic acid supplementation in pregnancy and risk of preeclampsia and gestational hypertension.MethodsThe relevant studies were included by retrieving the Embase, PubMed and Cochrane library databases. Data extraction was conducted by two investigators independently. The risk ratio (RR) and 95% confidence interval (CI) were used as effect indexes to evaluate the relationship between folic acid supplementation and risk of gestational hypertension or preeclampsia. A subgroup analysis was performed according to the supplementation patterns of folic acid. The homogeneity of the effect size was tested across the studies, and publication biases were examined.ResultsIn total, 13 cohort studies and 1 randomized controlled trial study was included, containing 160,562 and 149,320 women with and without folic acid supplementation during pregnancy. Pooled results showed that risk of gestational hypertension was not associated with the supplementation of folic acid. However, folic acid supplementation during pregnancy could significantly reduce the risk of preeclampsia. Moreover, the results of subgroup analysis showed that the decreased preeclampsia risk was associated with supplementation of multivitamins containing folic acid rather than folic acid alone.ConclusionsOur findings indicate that the supplementation of multivitamins containing folic acid during pregnancy could significantly lower preeclampsia risk.Electronic supplementary materialThe online version of this article (10.1007/s00404-018-4823-4) contains supplementary material, which is available to authorized users.

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“…However, other studies found that vitamin D deficiency did not play an important role in the outcome of ART [73,74,75,76,77]. Unfortunately, there is only a small amount of data showing the effects of vitamin D on the quality of embryos.…”

Section: Physiological Role Of Vitamin D In Reproduction -Endometriosismentioning

confidence: 97%

The role of vitamin D in reproductive dysfunction in women – a systematic review

Skowrońska¹,

Pastuszek²,

Kuczyński³

et al. 2016

Ann Agric Environ Med.

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Vitamin D is essential for the proper functioning of the human body. There is also evidence of its strong association with fertility problems in women. This review aims to evaluate the relationship between vitamin D and diseases affecting women's fertility (polycystic ovarian syndrome (PCOS), uterine leiomyomas and endometriosis), and in vitro fertilization (IVF) outcome. A systematic review of the literature was conducted in Scopus and PubMed for relevant English language publications since 1989. Vitamin D influences the functioning of the reproductive system in women and has been associated with PCOS, uterine leiomyomas, endometriosis and in vitro fertilization (IVF) outcome. However, further studies on larger groups of patients are needed to establish what role vitamin D plays in the treatment of female infertility.

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Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis

Abstract: There is no significant correlation between deficient serum vitamin D level and lower clinical pregnancy rate in infertile woman undergoing in vitro fertilization. On the other hand, deficient vitamin D level was related to lower live birth rate.

Cited by 49 publications

References 40 publications

The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data

The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data

Supplementation of folic acid in pregnancy and the risk of preeclampsia and gestational hypertension: a meta-analysis

The role of vitamin D in reproductive dysfunction in women – a systematic review

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