Serum vitamin D levels are decreased in patients without remission of Graves’ disease

Yasuda, Tetsuyuki; Okamoto, Yasuyuki; Hamada, Noboru; Miyashita, Kazuyuki; Takahara, Mitsuyoshi; Sakamoto, Fumie; Miyatsuka, Takeshi; Kitamura, Tatsuya; Katakami, Naoto; Kawamori, Dan; Otsuki, Michio; Matsuoka, Taka‐aki; Kaneto, Hideaki; Shimomura, Iichiro

doi:10.1007/s12020-012-9789-6

Cited by 60 publications

(51 citation statements)

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“…13 In contrast, others found that serum vitamin D levels were lower and associated with thyroid volume in female patients with new onset Graves' disease 7 and that serum vitamin D levels were lower in patients without remission of Graves' disease. 27 A recent study revealed that serum vitamin D levels in TSHR-Ab-positive GD patients were lower than in healthy controls or TSHR-Ab-negative patients and inversely correlated with TSHR-Ab titre. 28 In addition to the aforementioned meta-analysis, another metaanalysis of 26 studies showed that patients with GD are more likely to be deficient in vitamin D compared to controls with a high heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

Low vitamin D status is associated with hypothyroid Hashimoto’s thyroiditis

Kim¹

2016

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Section: Discussionmentioning

confidence: 99%

Low vitamin D status is associated with hypothyroid Hashimoto’s thyroiditis

Kim¹

2016

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“…Based on these results, the vitamin D levels at diagnosis of GD cannot be used for predicting relapse after termination of antithyroid drugs. In a Japanese study of 18 female patients in remission, 36 female patients without remission (discontinuing antithyroid drugs unattainable 4 years after therapy initiation and persistent TRAb positivity), and 49 healthy controls, the mean vitamin D levels were significantly lower in patients without remission than in those with remission [15]. However, the patients without remission were all TRAb positive, which per se is a strong prognostic factor of relapse, and the vitamin D levels do not add additional value in predicting relapse in this group.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D in Graves Disease: Levels, Correlation with Laboratory and Clinical Parameters, and Genetics

Planck¹,

Shahida²,

Malm³

et al. 2017

Eur Thyroid J

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Objective: The aim was to compare the vitamin D levels in patients with Graves disease (GD) with the general population and to correlate the vitamin D levels with laboratory and clinical parameters in GD. Moreover, we examined the genetic variation in genes involved in the vitamin D metabolism and their association with GD. Methods: The levels of vitamin D were compared in 292 patients with newly diagnosed GD and 2,305 controls. Single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR), vitamin D binding protein (DBP), and 1-α-hydroxylase (CYP27B1) were examined for association with GD and/or Graves ophthalmopathy (GO) in 708 patients and 1,178 controls. Results: Patients with GD had significantly lower vitamin D levels compared to controls (55.0 ± 23.2 vs. 87.2 ± 27.6 nmol/L, p < 0.001). In patients with GD (n = 219), there was no association between the levels of vitamin D at diagnosis and free thyroxine (fT₄), free triiodothyronine (fT₃), thyrotropin receptor antibodies (TRAb), GO at diagnosis, or relapse after terminating treatment with antithyroid drugs. Two SNPs in VDR were associated with GD: rs10735810 (OR = 1.36, 95% CI: 1.02–1.36, p = 0.02) and rs1544410 (OR = 1.47, 95% CI: 1.03–1.47, p = 0.02). There was no difference in the mean vitamin D level between genotypes in either rs10735810 or rs154410. Conclusions: Patients with GD had lower vitamin D levels compared to the general population; however, the vitamin D levels did not affect the laboratory or clinical parameters of GD. SNPs in the VDR influenced the risk of GD through mechanisms other than reducing the vitamin D levels.

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“…Furthermore, vitamin D 25(OH) level in female patients with GD was lower than in male patients (31.8±13.3 vs 41.3±15.0 nmol/L, p<0.001). This finding was strengthened by the study of Yasuda et al 10 which showed significantly lower vitamin D 25(OH) serum level in GD patients who did not have remission compared to those in patients with remission, or normal subjects (14.5±2.9 ng/mL in non-remission vs 18.2±5.1 ng/mL in remission p<0.005). 10 Both studies suggest the role of vitamin D level in the pathogenesis of GD.…”

Section: Conclusion: Sunlight Exposure Increases Vitamin D 25(oh)mentioning

confidence: 88%