Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA)

Zhao, Di; Ouyang, Pamela; Boer, Ian H. de; Lutsey, Pamela L.; Farag, Youssef M.K.; Güallar, Eliseo; Siscovick, David S.; Post, Wendy S.; Kalyani, Rita R.; Billups, Kevin L.; Michos, Erin D.

doi:10.1016/j.maturitas.2016.11.017

Cited by 62 publications

(60 citation statements)

References 40 publications

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“…With regard to the bioavailability of testosterone, the largest study to date demonstrated a negative relationship between vitamin D and fT among postmenopausal women, 14 which is consistent with our findings. With regard to SHBG, the positive relationship with vitamin D concentration that we observed is consistent with results observed previously among both women with PCOS 22,23 and postmenopausal women.…”

Section: Commentsupporting

confidence: 91%

“…With regard to SHBG, the positive relationship with vitamin D concentration that we observed is consistent with results observed previously among both women with PCOS 22,23 and postmenopausal women. 14,24 However, our positive finding conflicts with results from the aforementioned meta-analysis; 21 our study’s larger cohort (and therefore greater power) may also explain why we found a relationship between vitamin D and SHBG while the meta-analysis did not.…”

Section: Commentcontrasting

confidence: 81%

“…Studies have linked serum vitamin D to serum testosterone and sex hormone—binding globulin (SHBG) concentrations in populations of postmenopausal women and premenopausal women with PCOS, 12–14 but none have investigated this relationship in premenopausal, regularly cycling women. The SHBG data gap is especially important, given its role in binding freely circulating steroid hormones, including androgens, and thereby limiting their biological availability.…”

mentioning

confidence: 99%

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Vitamin D is associated with bioavailability of androgens in eumenorrheic women with prior pregnancy loss

Kuhr

Sjaarda

Alkhalaf

et al. 2018

American Journal of Obstetrics and Gynecology

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BACKGROUND: Prior studies have reported mixed results regarding relationships between vitamin D, androgens, and sex hormone—binding globulin in patients with polycystic ovary syndrome. However, less is known regarding these associations in eumenorrheic, premenopausal women. OBJECTIVE: Our objective was to study the relationships between serum vitamin D and androgen biomarkers in eumenorrheic women with a history of pregnancy loss who were attempting pregnancy. STUDY DESIGN: This was an analysis of a cohort of 1191 participants from the Effects of Aspirin in Gestation and Reproduction trial (2006e2012). Participants were attempting to conceive, aged 18—40 years, with 1—2 documented prior pregnancy losses and no history of infertility, and recruited from 4 academic medical centers in the United States. Serum vitamin D (25-hydroxyvitamin D) and hormone concentrations were measured at baseline. RESULTS: Vitamin D concentration was negatively associated with free androgen index (percentage change [95% confidence interval, —5% (—8% to —2%)] per 10 ng/mL increase) and positively associated with sex hormone—binding globulin (95% confidence interval, 4% [2—7%]), although not with total testosterone, free testosterone, or dehydroepiandrosterone sulfate after adjusting for age, body mass index, smoking status, race, income, education, physical activity, and season of blood draw. CONCLUSION: Overall, vitamin D was associated with sex hormone—binding globulin and free androgen index in eumenorrheic women with prior pregnancy loss, suggesting that vitamin D may play a role in the bioavailability of androgens in eumenorrheic women. We are limited in making assessments regarding directionality, given the cross-sectional nature of our study.

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Section: Commentsupporting

confidence: 91%

Section: Commentcontrasting

confidence: 81%

mentioning

confidence: 99%

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Vitamin D is associated with bioavailability of androgens in eumenorrheic women with prior pregnancy loss

Kuhr

Sjaarda

Alkhalaf

et al. 2018

American Journal of Obstetrics and Gynecology

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“…We also newly showed that deficient 25(OH)D was more strongly associated with an adverse lipid profile of higher LDL-C and lower HDL-C in women compared to men. We previously have found that lower 25(OH)D was associated with a more androgenic sex hormone pattern in women,[25] which may be another potential mechanism how vitamin D impacts HDL-C.…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D and change in lipid levels over 5 y: The Atherosclerosis Risk in Communities study

et al. 2017

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Background 25-hydroxyvitamin D [25(OH)D] deficiency is associated with increased cardiovascular disease risk, perhaps mediated through dyslipidemia. Deficient 25(OH)D is cross-sectionally associated with dyslipidemia, but little is known about longitudinal lipid changes. Our objective was to determine the association of 25(OH)D deficiency with longitudinal lipid changes and risk of incident dyslipidemia. Research Methods This is a longitudinal community-based study of 13,039 ARIC participants who had 25(OH)D and lipids measured at baseline (1990–1992) and lipids re-measured in 1993–1994 and 1996–1998. Mixed-effect models were used to assess associations of 25(OH)D with lipid trends after adjusting for clinical characteristics and for baseline or incident use of lipid-lowering therapy. Risk of incident dyslipidemia was determined for those without baseline dyslipidemia. Results Baseline mean±SD age was 57±6 years and 25(OH)D was 24±9 ng/ml. Participants were 57% women, 24% black. Over a mean follow-up of 5.2 years, the fully-adjusted average differences (95% CI) comparing deficient (<20 ng/ml) to optimal (≥30 ng/ml) 25(OH)D were: total cholesterol (TC) −2.40 mg/dl (−4.21, −0.60), HDL-cholesterol -3.02 mg/dl (−3.73, −2.32) and TC/HDL-C ratio 0.18 (0.11, 0.26). Those with deficient 25(OH)D compared to optimal had modestly increased risk of incident dyslipidemia in demographic-adjusted models [RR 1.19 (1.02–1.39)], which was attenuated in fully-adjusted models [1.12 (0.95–1.32)]. Conclusions Deficient 25(OH)D was prospectively associated with lower TC and HDL-C and greater TC/HDL-C ratio after considering factors such as diabetes and adiposity. Further work including randomized controlled trials is needed to better assess how 25(OH)D may impact lipids and cardiovascular risk.

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“…This result might be attributed to the different levels of androgenic hormones among men and women. The testosterone level was higher among men than among women . A prior study showed that testosterone level is a predictor of handgrip strength among men .…”

Section: Discussionmentioning

confidence: 85%

Relationship among urinary advanced glycation‐end products, skeletal muscle mass and physical performance in community‐dwelling older adults

Yang

Liu

et al. 2019

Geriatrics Gerontology Int

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Aim Advanced glycation end‐products are important factors in muscle function and physical performance among older adults. However, the association between sarcopenia and urinary carboxymethyl‐lysine (uCML) levels remains unclear. The present study aimed to investigate the relationship among uCML levels, skeletal muscle mass, physical performance and sarcopenia among community‐dwelling older adults. Methods This work was a community‐based cross‐sectional study. The participants were recruited from the Taichung Community Health Study‐Elderly and were followed up until 2017. A total of 104 participants underwent dual‐energy X‐ray absorptiometry examination, physical performance tests and measurement of uCML levels. After the natural log transformation of the uCML levels, Pearson's correlation coefficient and a general linear model were used for statistical analysis. Results The mean uCML levels of older men and women were 1.34 μg/mg and 1.63 μg/mg creatinine, respectively. After multivariate adjustment, grip strength among older women significantly decreased as uCML levels increased. Participants with uCML levels and Timed Up and Go test values higher than the median had a 13.76‐fold risk of acquiring sarcopenia compared with those whose corresponding variables were lower than the median after adjusting for age, sex, body fat percentage, and serum creatinine and blood urea nitrogen levels. Conclusions uCML levels were negatively associated with grip strength among older women. The joint association of uCML and Timed Up and Go test values was correlated with the risk of acquiring sarcopenia among older adults. This finding suggests that uCML levels can be used as a biomarker for screening sarcopenia and as a strategy for treating sarcopenia. Geriatr Gerontol Int 2019; 19: 1017–1022.

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Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA)

Cited by 62 publications

References 40 publications

Vitamin D is associated with bioavailability of androgens in eumenorrheic women with prior pregnancy loss

Vitamin D is associated with bioavailability of androgens in eumenorrheic women with prior pregnancy loss

Serum vitamin D and change in lipid levels over 5 y: The Atherosclerosis Risk in Communities study

Relationship among urinary advanced glycation‐end products, skeletal muscle mass and physical performance in community‐dwelling older adults

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