Serum Vitamin D and Long-term Outcomes of Benign Paroxysmal Positional Vertigo

Abstract

Objectives The purpose of the present study was to examine the effect of serum vitamin D concentrations on the longterm recurrence rates of benign paroxysmal positional vertigo (BPPV) patients. Methods The present study was conducted with patients diagnosed with BPPV from June 2014 to April 2016. Whether the patients’ sex, age, types and locations of semicircular canals, diabetes, hypertension, hyperlipidemia, and vitamin D concentrations affect their recurrence rates was examined using Pearson chi-square tests, independent samples t -tests and Cox proportional hazards regression analyses. The effects of vitamin D concentrations on long-term recurrence rates were examined using Kaplan-Meier estimates and log-rank tests. Results The recurrence rates obtained with Kaplan-Meier estimates were 18% and 50% at 12 months and 24 months, respectively. When the patients were divided into groups with vitamin D concentrations of <10 ng/mL and ≥10 ng/mL and the recurrence rates of the groups were compared, the difference was statistically significant ( P =0.040). In addition, when the patients were divided into groups with vitamin D concentrations of <15 ng/mL and ≥15 ng/mL and the recurrence rates of the groups were compared, the difference was statistically quite significant ( P =0.017). In a Cox regression model, variables such as age, sex, the types and locations of semicircular canals, hypertension, diabetes, hyperlipidemia, and 25-hydroxy vitamin D did not significantly affect recurrence. Conclusion The present study investigated the recurrence rates of BPPV in patients for a long time without limiting the sex, age, or locations of semicircular canals and it could be seen that serum vitamin D concentrations significantly affected the recurrence of BPPV.

Biochemical and Pain Comparisons Between the Laser Lancing Device and Needle Lancets for Capillary Blood Sampling: A Randomized Control Trial

“…Blood sampling with less pain can be useful clinically [25][26][27][28][29][30]. In addition to self-measuring blood glucose in patients with diabetes mellitus, it can be used for gas analysis in the intensive care unit and biochemical component analysis.…”

Causes and treatment of idiopathic benign paroxysmal positional vertigo based on endocrinological and other metabolic factors

“…Therefore, some reports have not been able to establish a causal relationship ( Jeong et al., 2013 ). Although there are studies with controversial results in developing a linear relationship between vitamin D and recurrences ( Karataş et al., 2017 ), there is significant evidence when comparing groups with low plasma levels of this vitamin ( Ding et al., 2019 ; Rhim, 2019 ). Lower plasma levels of vitamin D in patients with canalolithiasis compared to those with cupulolithiasis have been reported in subjects diagnosed with posterior canal BPPV ( Maslovara et al., 2018 ), a result confirmed in a subsequent study in a group of patients with horizontal canal involvement ( Nakada et al., 2019 ).…”

Serum vitamin D and Recurrent Benign Paroxysmal Positional Vertigo

“…The did not affect the recurrence rate of BPPV [10]. Soto-Varela and his colleagues reported same results [11].…”