Serum vitamin B12 deficiency and hyperhomocystinemia: A reversible cause of acute chorea, cerebellar ataxia in an adult with cerebral ischemia

Shyambabu, C.; Sinha, Sanjib; Taly, AB; Vijayan, Joy; Kovoor, J.M.E.

doi:10.1016/j.jns.2008.06.034

Cited by 23 publications

(11 citation statements)

References 15 publications

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“…18,19,20,26 This is typically observed following 2-3 months of treatment. 18,20,27 Conclusions Resolution of neurological signs subsequent to cobalamin supplementation supports a diagnosis of encephalopathy secondary to acquired cobalamin deficiency, of which this is the first reported case in a cat. Hypocobalaminaemia should be considered a differential diagnosis in cats displaying compatible neurological signs.…”

Section: Cobalamin-dependent Enzymatic Pathwaysmentioning

confidence: 82%

Suspected acquired hypocobalaminaemic encephalopathy in a cat: resolution of encephalopathic signs and MRI lesions subsequent to cobalamin supplementation

Simpson

Battersby

Lowrie

2012

Journal of Feline Medicine and Surgery

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Section: Cobalamin-dependent Enzymatic Pathwaysmentioning

confidence: 82%

Suspected acquired hypocobalaminaemic encephalopathy in a cat: resolution of encephalopathic signs and MRI lesions subsequent to cobalamin supplementation

Simpson

Battersby

Lowrie

2012

Journal of Feline Medicine and Surgery

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“…Screening for thyroid disease and vitamin B12 deficiency should be performed in evaluating any new movement disorder [81,82] as both can be successfully treated. Disturbances of calcium metabolism, related to parathyroid disorders, should also be considered, especially in paroxysmal movement disorders.…”

Section: Metabolic Disordersmentioning

confidence: 99%

Diagnosis and Treatment of Chorea Syndromes

Hermann

Walker

2015

Curr Neurol Neurosci Rep

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Chorea is a common movement disorder which can be caused by a large variety of diseases including neurodegenerative diseases, metabolic diseases, and autoimmune diseases, or can be secondary to structural changes. The basal ganglia seem to be mainly involved in the pathophysiology indicating the vulnerability of this region. The diagnosis can be challenging, especially if chorea occurs during the treatment of neuropsychiatric conditions, and in these cases, it is difficult to distinguish between medication side effects (i.e., tardive dyskinesia) and the development of a neurodegenerative disease. Most therapeutic approaches are predominantly symptomatic, with a focus on multidisciplinary care for many patients. Nevertheless, some underlying diseases can be successfully treated and must not be missed. In this review, we summarize recent new developments in the differential diagnosis of chorea syndromes and suggest a pathway for a successful diagnosis of chorea in infancy, childhood, and adulthood for daily practice.

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“…Extrapyramidal symptoms including cerebellar ataxia, dystonia, and chorea have also been reported, but they are not common. 6 Although there is insufficient evidence at present, it has been reported that copper, zinc, vitamin A, vitamin B6, and vitamin B12 deficiency may cause olfactory dysfunction. 7,8 A significant role of vitamin B12 in maintaining neurological symptoms, and the appearance of neurological disorders in the case of vitamin B12 deficiency suggest that vitamin B12 deficiency may affect olfactory function in a negative way.…”

mentioning

confidence: 99%

“…6,12,13 Cognitive and psychiatric disorders may be seen in patients with vitamin B12 deficiency. It has been suggested that vitamin B12 deficiency contributes to the pathogenesis of depressive disorders, mental confusion, affective disorders, delirium, and paranoid psychosis.…”

mentioning

confidence: 99%