Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect

Ceyhan, Seyit Temel; Beyan, Cenǵiz; Atay, Vedat; Yaman, Halıl; Alanbay, İbrahim; Kaptan, Kürşat; Başer, İskender

doi:10.3109/09513591003632183

Cited by 27 publications

(31 citation statements)

References 26 publications

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“…Mobasheri et al (18) reported that levels of folate and vitamin B12 did not significantly affect NTD risk in 23 women with NTD fetuses and 23 healthy controls. Ceyhan et al (19) carried out a study similar to ours on 31 pregnant women with fetal NTDs and 32 controls with healthy fetuses. In their study, no relation was shown between vitamin B12 levels and NTDs.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of maternal serum folate, vitamin B12, and homocysteine levels andfactor V Leiden, factor II g.20210G>A, and MTHFR variations in prenatallydiagnosed neural tube defects

Aydın¹,

Arısoy²,

Karaman³

et al. 2016

Turk J Med Sci

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Background/aim: Neural tube defects (NTDs) are common congenital malformations that develop as a result of interactions between several genes and environmental factors. Many factors have been investigated in order to understand the etiology of NTDs, and many studies have identified folate intake as a common contributing factor. The exact etiology of the disease is still unknown. Materials and methods:In this study, we compared serum folate, vitamin B12, and homocysteine levels, along with common thrombophilia-related genetic variations, including factor V Leiden, factor II g.20210G>A, MTHFR c.677C>T, and MTHFR c.1298A>C, in 35 pregnant women with fetal NTDs and 38 pregnant women with healthy fetuses.Results: A significant difference in serum vitamin B12 level and factor V Leiden frequency was detected between the two groups. On the other hand, serum folate, homocysteine levels, and factor II g.20210G>A, MTHFR c.677C>T, and MTHFR c.1298A>C were not significantly different in the NTD group compared to the controls. Conclusion:These results indicate that vitamin B12 supplementation along with folate may help in lowering NTD frequency. In addition, this is the first study that provides evidence for a possible relationship between increased NTD risk and factor V Leiden.

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Section: Discussionmentioning

confidence: 99%

Evaluation of maternal serum folate, vitamin B12, and homocysteine levels andfactor V Leiden, factor II g.20210G>A, and MTHFR variations in prenatallydiagnosed neural tube defects

Aydın¹,

Arısoy²,

Karaman³

et al. 2016

Turk J Med Sci

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“…Increased total homocysteine has been found in plasma [37,40,155,156,157,158,159] and in amniotic fluid [34,160] of women with NTD affected fetuses or with a history of NTD affected fetuses although these results are inconsistent [34,35,38,161,162,163,164,165,166]. Increased S-adenosylhomocysteine has also been noted in plasma of women with a history of NTD [40,166].…”

Section: Arguments For the Implication Of Homocysteine Vitamin B1mentioning

confidence: 99%

“…Vitamin B12 concentrations were investigated in maternal blood of women carrying a NTD affected fetus or women with a history of NTD affected fetus (reviewed in [180]). Some of these studies have found lower B12 concentrations in these mothers compared to controls [38,156,157,162,164,181,182,183,184,185,186] while others do not reach statistical significance [30,32,40,159,161,163,165,187,188,189,190,191]. Two meta-analysis have identified an association between low maternal serum vitamin B12 and the risk of NTDs [192,193].…”

Section: Arguments For the Implication Of Homocysteine Vitamin B1mentioning

confidence: 99%

Neural Tube Defects, Folic Acid and Methylation

Imbard

Benoist

Blom

2013

IJERPH

217

164

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Neural tube defects (NTDs) are common complex congenital malformations resulting from failure of the neural tube closure during embryogenesis. It is established that folic acid supplementation decreases the prevalence of NTDs, which has led to national public health policies regarding folic acid. To date, animal studies have not provided sufficient information to establish the metabolic and/or genomic mechanism(s) underlying human folic acid responsiveness in NTDs. However, several lines of evidence suggest that not only folates but also choline, B12 and methylation metabolisms are involved in NTDs. Decreased B12 vitamin and increased total choline or homocysteine in maternal blood have been shown to be associated with increased NTDs risk. Several polymorphisms of genes involved in these pathways have also been implicated in risk of development of NTDs. This raises the question whether supplementation with B12 vitamin, betaine or other methylation donors in addition to folic acid periconceptional supplementation will further reduce NTD risk. The objective of this article is to review the role of methylation metabolism in the onset of neural tube defects.

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“…Low concentrations of Cbl in the mother’s serum have been linked with increased risk of neural tube defects, (NTD) in Irish, Canadian, Chinese, and Egyptian populations [33,34,35,36,37]. However, other studies have found no effect of Cbl status [38,39,40,41,42,43,44,45,46,47]. These results have been reviewed by Ray and Blom 2003, who identified a moderate association between low maternal serum Cbl levels and risk of NTD [48].…”

Section: Cobalamin Deficiency Polymorphism and Risk Of Neural Tubmentioning

confidence: 99%

Vitamin B12 Metabolism during Pregnancy and in Embryonic Mouse Models

2013

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Vitamin B12 (cobalamin, Cbl) is required for cellular metabolism. It is an essential coenzyme in mammals for two reactions: the conversion of homocysteine to methionine by the enzyme methionine synthase and the conversion of methylmalonyl-CoA to succinyl-CoA by the enzyme methylmalonyl-CoA mutase. Symptoms of Cbl deficiency are hematological, neurological and cognitive, including megaloblastic anaemia, tingling and numbness of the extremities, gait abnormalities, visual disturbances, memory loss and dementia. During pregnancy Cbl is essential, presumably because of its role in DNA synthesis and methionine synthesis; however, there are conflicting studies regarding an association between early pregnancy loss and Cbl deficiency. We here review the literature about the requirement for Cbl during pregnancy, and summarized what is known of the expression pattern and function of genes required for Cbl metabolism in embryonic mouse models.

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Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect

Abstract: It seems that vitamin B12 deficiency does not play a causative role in the development of foetal NTD. Monitoring maternal homocystein levels might be important in understanding the aetiologies of foetal NTD.

Cited by 27 publications

References 26 publications

Evaluation of maternal serum folate, vitamin B12, and homocysteine levels andfactor V Leiden, factor II g.20210G>A, and MTHFR variations in prenatallydiagnosed neural tube defects

Evaluation of maternal serum folate, vitamin B12, and homocysteine levels andfactor V Leiden, factor II g.20210G>A, and MTHFR variations in prenatallydiagnosed neural tube defects

Neural Tube Defects, Folic Acid and Methylation

Vitamin B12 Metabolism during Pregnancy and in Embryonic Mouse Models

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