Serum vitamin A levels in psoriasis: results from the First National Health and Nutrition Examination Survey

Safavi, K.

doi:10.1001/archderm.128.8.1130

Cited by 18 publications

(5 citation statements)

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“…Our results are in agreement with the results of Safavi [7] and Marrakchi et al [9]. We also did not find any correlation among plasma vitamin A and E levels, TBUT and the severity and duration of the disease.…”

Section: Discussionsupporting

confidence: 93%

“…In a study by Majewski et al [6], plasma level of vitamin A was found to be decreased in psoriatic patients as compared with the values in an age- and gender-matched group. Safavi [7] observed no evidence of decreased plasma vitamin A level in patients with psoriasis, but found a decrease in plasma vitamin A level that was related to age and gender. Kokcam and Nazıroglu [8] did not find a significant difference in plasma vitamin E levels in patients with psoriasis, but plasma beta carotene level, a precursor of vitamin A, was decreased.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Plasma Vitamin A and E Levels and Tear Film Changes in Patients with Psoriasis Vulgaris

Demir

Aydın

Sezer

et al. 2013

Korean J Ophthalmol

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PurposeTo evaluate whether alterations in plasma vitamin A and E levels in patients with psoriasis have an effect on tear film changes.MethodsSixty-two eyes of 31 patients with psoriasis vulgaris (Group A) and 74 eyes of 37 age- and gender-matched control subjects (Group B) were included in the study. Ocular and medical histories and dietary habits were obtained from each patient. The tear film break-up time (TBUT), the Schirmer 1 test results and plasma vitamin A and E levels were evaluated.ResultsThe mean Schirmer 1 test score was 14.76 ± 6.12 mm/5 min in Group A and 15.69 ± 3.10 mm/5 min in Group B. The mean plasma levels of vitamins A and E in Groups A and B were 1.86 ± 0.62 µmol/L and 1.88 ± 0.65 µmol/L vs. 26.21 ± 5.13 µmol/L and 27.19 ± 8.89 µmol/L, respectively. The Schirmer 1 test results and plasma vitamin A and E levels were not found to be significantly different between the groups (p > 0.05). The mean TBUT was 9.94 ± 6.18 seconds in Group A and 14.47 ± 5.65 seconds in Group B, a significant difference (p < 0.05). No correlation existed between plasma vitamin A and E levels, TBUT or the severity and duration of the disease (p > 0.05).ConclusionsPlasma vitamin A and E levels do not seem to be related to tear film changes in patients with psoriasis vulgaris.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Evaluation of Plasma Vitamin A and E Levels and Tear Film Changes in Patients with Psoriasis Vulgaris

Demir

Aydın

Sezer

et al. 2013

Korean J Ophthalmol

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“…For decidualizing HESCs, confluent monolayers were maintained in DMEM without phenol red (REF11039-021, GIBCO, life technologies, Grand Island, USA) containing 2% DCC-FBS and treated with 0.5 mM 8-bromoadenosine 3’5’-cyclic AMP (8-bromo-cAMP; B7880,SIGMA,USA), 1 μM progesterone (P 4 ; P0130, SIGMA, China), and 0.1 μM cortisone (E; C2755,SIGMA,China) in combination with 10 −8 M to 10 −11 M all trans -RA (atRA; R2625, SIGMA, China) or 10 −8 M all-trans Rald (atRald; R2500,SIGMA,China). Normal serum levels of vitamin A are between 1–2.5 × 10 −6 M [ 29 ]. A previous study showed that atRA at a concentration of 10 −8 M or higher inhibits decidualization of HESCs [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

Reprogramming of the retinoic acid pathway in decidualizing human endometrial stromal cells

et al. 2017

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Upon breaching of the endometrial surface epithelium, the implanting embryo embeds in the decidualizing stroma. Retinoic acid (RA), a metabolite of vitamin A, is an important morphogen during embryonic and fetal development, although the role of the RA pathway in the surrounding decidual cells is not understood. Here we show that decidual transformation of human endometrial stromal cells (HESCs) results in profound reprogramming of the RA signaling and metabolism pathways. Differentiating HESCs downregulate the intracellular carrier proteins CRABP2 and FABP5, responsible for transfer and binding of RA to the nuclear receptors RAR and PPARβ/δ, respectively. Furthermore, the expression of RAR, the receptor that mediates the pro-apoptotic effects of RA, was also inhibited. By contrast, PPARβ/δ, which transduces the differentiation responses of RA, was upregulated. Decidualization was also associated with increased expression of retinol-binding protein 4 (RBP4) and various enzymes involved in the metabolism of RA and its precursor, retinaldehyde (Rald), including CYP26A1, DHRS3, and RDH12. Exposure of differentiating HESCs to RA or Rald reversed the inhibition of the CRABP2-RAR pathway, perturbed the expression of decidual marker genes and triggered cell death. Taken together, the data demonstrate that decidualizing HESCs silence RA signaling by downregulating key cytoplasmic binding proteins and by increasing retinoid metabolism. However, excessive RA exposure is toxic for decidual cells and triggers a response that may lead to pregnancy failure.

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“…Alopecia areata is a common form of autoimmune hair loss with a lifetime prevalence of approximately 2%, occurring at any age (20). Approximately 20% of patients are under 16 and 1–2% present before age 2 (21, 22).…”

Section: Alopecia Areatamentioning

confidence: 99%

A Practical Approach to the Diagnosis and Management of Hair Loss in Children and Adolescents

Liu

Senna

2017

Front. Med.

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Hair loss or alopecia is a common and distressing clinical complaint in the primary care setting and can arise from heterogeneous etiologies. In the pediatric population, hair loss often presents with patterns that are different from that of their adult counterparts. Given the psychosocial complications that may arise from pediatric alopecia, prompt diagnosis and management is particularly important. Common causes of alopecia in children and adolescents include alopecia areata, tinea capitis, androgenetic alopecia, traction alopecia, trichotillomania, hair cycle disturbances, and congenital alopecia conditions. Diagnostic tools for hair loss in children include a detailed history, physical examination with a focused evaluation of the child's hair and scalp, fungal screens, hair pull and tug test, and if possible, light microscopy and/or trichoscopy. Management of alopecia requires a holistic approach including psychosocial support because treatments are only available for some hair loss conditions, and even the available treatments are not always effective. This review outlines the clinical presentations, presents a diagnostic algorithm, and discusses management of these various hair loss disorders.

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Serum vitamin A levels in psoriasis: results from the First National Health and Nutrition Examination Survey

Cited by 18 publications

References 0 publications

Evaluation of Plasma Vitamin A and E Levels and Tear Film Changes in Patients with Psoriasis Vulgaris

Evaluation of Plasma Vitamin A and E Levels and Tear Film Changes in Patients with Psoriasis Vulgaris

Reprogramming of the retinoic acid pathway in decidualizing human endometrial stromal cells

A Practical Approach to the Diagnosis and Management of Hair Loss in Children and Adolescents

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