Serum vitamin A, E and C status in cervical cancer patients undergoing Concurrent Chemo-Radiotherapy, an institutional study

Shrivastava, Anju; Pradhan, Satyajit; Mishra, Sarita; Asthana, Anjana; Choudhary, Sunil; Zahra, Kulsoom; Aggarwal, Lalit Mohan

doi:10.1016/j.jnim.2019.100107

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…A signifi cant increase in vitamin A levels in cervical cancer patients after 3 months of chemotherapy follow-up, but during and after chemotherapy the levels of vitamin A in cervical cancer patients in all stages were lower than before chemotherapy. 30 In patients with advanced-stage cervical carcinoma who were given neoadjuvant chemotherapy (NAC) Cisplatin and Paclitaxel with additional vitamin A, after 3 cycles of chemotherapy, there was a change in tumor volume size in the neoadjuvant chemotherapy group plus vitamin A greater than the neoadjuvant chemotherapy group alone. (p = 0.04).…”

Section: Discussionmentioning

confidence: 99%

“…Decreased levels of vitamins played a role in the etiology and development of cervical cancer. 30 Retinol and vitamin A derivatives affected cell differentiation, proliferation, and apoptosis and played an important physiological roles in various biological processes. Retinoids had many important and diverse functions throughout the body including roles in the regulation of cell proliferation and differentiation, and the activation of tumor suppressor genes.…”

Section: Discussionmentioning

confidence: 99%

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The Efficacy of Chemotherapy in Advanced-Stage Cervical Cancer on Vitamin A Serum

Rizal

Sanif²,

Novaliani

et al. 2022

Indones J Obstet Gynecol

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Abstract Objective: To determine the efficacy of neoadjuvant chemotherapy on changes of vitamin A serum in advanced cervical carcinoma patient. Method: A randomized clinical trial was performed in the Oncology Gynecology Polyclinic and Ward of Dr. Mohammad Hoesin General Hospital, Palembang from September 2019 to September 2020. There were 30 subjects of advanced cervical carcinoma. Vitamin A levels and tumor volume subjects were assessed before and 1 month after 3 cycles of NAC and analyzed using the Paired T Test and Wilcoxon test. The correlation between vitamin A levels and tumor volume was analyzed by using Spearman's Rho test. Data analysis was using SPSS version 22.0. Results: This study showed statistically not significant increase on vitamin A levels after 3 cycles of NAC chemotherapy (p=0.515). However, there was a significantly decrease in tumor volume after 3 cycles of NAC (p=0.000). In addition, there was a moderate negative correlation between tumor size and vitamin A (r=-0.475; p=0.008). Conclusion: It can be concluded that there was significantly decrease in tumor volume after 3 series NAC chemotherapy and the smaller tumor size, the higher level of vitamin A serum. Keywords: cervical cancer, neoadjuvant chemotherapy, randomized clinical trial, vitamin A, Abstrak Tujuan: Untuk mengetahui efektivitas kemoterapi neoadjuvan terhadap perubahan kadar serum vitamin A pada karsinoma servik stadium lanjut. Metode: Penelitian uji klinik tanpa pembanding telah dilakukan di Poliklinik dan Bangsal Onkologi Ginekologi RSUP Dr. Muhammad Hoesin Palembang sejak September 2019 hingga September 2020. Didapatkan 30 sampel karsinoma serviks stadium lanjut. Kadar vitamin A dan volume tumor dinilai sebelum dan 1 bulan setelah 3 siklus NAC dan dianalsis menggunakan uji Paired T Test dan Wilcoxon. Korelasi antara Kadar vitamin A dan volume tumor sampel dianalisis menggunakan uji Spearman Rho’s. Analisa data menggunakan SPSS versi 22.0. Hasil : Pada penelitian ini terdapat peningkatan tidak signifikan kadar vitamin A setelah kemoterapi (p = 0,515). Terdapat penurunan secara signifikan volume tumor sebelum dan sesudah kemoterapi NAC 3 seri (p = 0,000). Selain itu, didapatkan korelasi negatif sedang yang bermakna antara ukuran tumor dan kadar vitamin A ( r = -0,475 ; p = 0,008). Simpulan : Disimpulkan bahwa terdapat penurunan volume tumor setelah kemoterapi NAC 3 series dan semakin kecil ukuran tumor maka semakin tinggi kadar vitamin A dalam serum. Kata kunci: kanker serviks, kemoterapi neoadjuvan, uji klinik tanpa pembanding, vitamin A.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Efficacy of Chemotherapy in Advanced-Stage Cervical Cancer on Vitamin A Serum

Rizal

Sanif²,

Novaliani

et al. 2022

Indones J Obstet Gynecol

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“…Dropin vitamins level A, C and E during cancer chemotherapyindirectly spectacles boost in freeradicals within body, which specifies usefulness of treatment15 but shrunk antioxidant vitamins status may play a part in etiology of manifold diseases. Antioxidants put forth a shielding effect counter to free radicals 18,19 .…”

Section: Discussionmentioning

confidence: 99%

“…Vitamins A, C and E are indispensable micronutrients which turns to be robust antioxidants in countless biological processes 18,19 .…”

Section: Introductionmentioning

confidence: 99%

Interrelationship of Electrolyte and Vitamins Profile in Patients Experiencing Tumor Lysis Syndrome

Mastoor¹,

Suhail²,

Azam³

et al. 2021

PJMHS

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Background:Tumor lysis syndrome is a metabolic derangement which is seen in patients with malignancy and receiving drugs for cancer treatment. It can arise in children or older cancer patients and is considered life threatening. Anticancer drug therapy is most commonly used method to treat cancer. Aim: To investigate the role of electrolytes and vitamins (A, C and E) in cancer patients suffering from tumor lysis syndrome during anticancer therapy. Study design: Prospective clinical study Methods: The study enrolled fifty diagnosed patients of Tumor lysis syndrome.Informed consent was taken from patients.Twenty patients, clinically healthy, age and sex-matched were selected as a control in the present study. 5cc blood was withdrawn from enrolled cases. The obtained samples were centrifuged at the speed of 4000-5000rpm for 10-15 minutes to obtain serum. The levels of Electrolytes (Na+, K+), and Vitamins A, C, E were estimated. Results: Study showed elevated serum levels of sodium (Na+) (28.26) in comparison withcontrol normal persons (21.26) and this is significant statistically (0.02<0.05). Serum Potassium levels among Tumor lysis syndrome (TLS) cases was (13.26) as observed in normal controlled persons (14.26) and results were significant statistically (0.03<0.05). Vitamin A level in Tumor lysis syndrome(TLS) cases decreased outstandingly (102.20) in contrast to normal control study persons.(188.26) and this is significant statistically (0.026<0.05). The values for Vitamin E in Tumor lysis syndrome cases was (4.26) and in controlled normal individuals (7.26) and proved significant statistically (0.015<0.05). Conclusion: Present study showed inverse relationship between Vitamins and electrolytes in TLS. Increased level of electrolyte imbalances and decreased vitamin levels is the reason responsible for the development of tumor lysis syndrome. Keywords: TLS, Vit A, Vit C, Vit E, Na+,K+

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“…Cancer patients frequently experience nutritional deficiencies due to a variety of reasons ranging from lack of appetite, changes in taste, and decreases in mental wellbeing, to increased biological demands associated with cancer and chemo/radiotherapy [12][13][14][15][16][17]. These nutritional deficiencies have substantial implications for disease progression, with some studies citing an approximated 30% increase in mortality in malnourished cancer patients [12].…”

Section: Introductionmentioning

confidence: 99%

Vitamin C for the Treatment of Depression in Cancer Patients: A Literature Review

Kerner

Eckstrand

2022

URNCST Journal

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Serum vitamin A, E and C status in cervical cancer patients undergoing Concurrent Chemo-Radiotherapy, an institutional study

Cited by 5 publications

References 23 publications

The Efficacy of Chemotherapy in Advanced-Stage Cervical Cancer on Vitamin A Serum

The Efficacy of Chemotherapy in Advanced-Stage Cervical Cancer on Vitamin A Serum

Interrelationship of Electrolyte and Vitamins Profile in Patients Experiencing Tumor Lysis Syndrome

Vitamin C for the Treatment of Depression in Cancer Patients: A Literature Review

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