Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men

Sun, Guang; Bishop, Jessica; Khalili, Sammy; Vasdev, Sudesh; Gill, Vicki; Pace, David; Fitzpatrick, Donald G.; Randell, Edward; Xie, Yazhou; Zhang, Hongwei

doi:10.1093/ajcn/85.2.399

Cited by 87 publications

(61 citation statements)

References 34 publications

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“…Positive correlation of visfatin and triglycerides, found in our patients with impaired glucose metabolism, was also shown in patients with newly diagnosed type 2 diabetes [24] in obese women with metabolic syndrome [26] and in healthy young men [27]. Hypertriglyceridemia is typical for individuals with visceral obesity and insulin resistance.…”

Section: Rycina 3 Korelacja Pomiędzy Wisfatyną a Hba 1c W Grupie A supporting

confidence: 70%

Stężenie wisfatyny u osób z otyłością w zależności od obecności świeżo wykrytych zaburzeń gospodarki węglowodanowej

Kamińska

Kopczyńska

Bieliński

et al. 2015

Endokrynologia Polska

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 Visfatin concentrations in obese patients in relation to the presence of newly diagnosed glucose metabolism disordersStężenie wisfatyny u osób z otyłością w zależności od obecności świeżo wykrytych zaburzeń gospodarki węglowodanowej AbstractIntroduction: Visfatin, protein secreted by visceral adipose tissue, exerts insulin-mimetic actions. Visfatin concentration increases in patients with longer-standing diabetes type 2 with progressive b-cell dysfunction. Data about the role of visfatin in newly diagnosed glucose metabolism abnormalities are limited. Evaluation of visfatin concentration in patients with obesity, in relation to the presence of newly diagnosed glucose metabolism disorders. Material and methods:The study included 68 subjects with obesity, without a previous diagnosis of abnormal glucose metabolism. In all subjects we performed an oral glucose tolerance test, and according to the results the group was divided into the subgroups: A (n = 31), with glucose metabolism disorders (impaired fasting glucose, impaired glucose tolerance and type 2 diabetes); and B (n = 37), without abnormalities. In all subjects serum lipids, uric acid, C-peptide, glycated haemoglobin (HbA 1c ), creatinine, and serum visfatin concentrations were measured. The control group comprised 30 lean, healthy individuals with normal glucose tolerance. Results: We found elevated visfatin levels in obese individuals versus the control group (50.0 ± 48 vs. 26.7 ± 22.1 ng/mL; p = 0.01). Visfatin concentrations in both subgroups, A and B, did not differ (40.86 ± 27.84 vs. 57.7 ± 59.79 ng/mL; p = 0.19). In subgroup A visfatin concentration correlated significantly with triglycerides (r = 0.37, p = 0.038), HbA 1c (r = -0.43, p = 0.02), C-peptide (r = -0.38,p = 0.048), and waist-hip ratio (r = -0.41, p = 0.036). Conclusions: The presence of newly diagnosed glucose metabolism abnormalities in obese subjects had no influence on the visfatin level, probably due to preserved endogenous insulin secretion and relatively short exposure to hyperglycaemia in patients with prediabetes or at early stage of type 2 diabetes. (Endokrynol Pol 2015; 66 (2): 108-113)

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Section: Rycina 3 Korelacja Pomiędzy Wisfatyną a Hba 1c W Grupie A supporting

confidence: 70%

Stężenie wisfatyny u osób z otyłością w zależności od obecności świeżo wykrytych zaburzeń gospodarki węglowodanowej

Kamińska

Kopczyńska

Bieliński

et al. 2015

Endokrynologia Polska

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“…We have found a positive association between circulating NAMPT levels and triglycerides, totaland LDL-cholesterol suggesting a role of NAMPT in lipid homeostasis. In line with this observation, a role of NAMPT in lipid metabolism has been put forward due to its strong correlation with serum triglycerides independently of age and BF [47,48] and with total-and LDL-cholesterol [49]. Contrarily, plasma NAMPT levels have been associated with a high HDL-cholesterol/low triglyceride plasma lipid profile [50].…”

Section: Discussionmentioning

confidence: 91%

Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity

Catalán

Gómez-Ambrosi

Rodríguez

et al. 2010

Nutrition, Metabolism and Cardiovascular Diseases

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Background and aims: Nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine with physiological effects on the control of glucose homeostasis as well as potentially involved in inflammation. The association of circulating NAMPT concentrations with obesity has not been clearly established. The aim of the present work was to evaluate the effect of obesity on circulating concentrations and gene expression levels of NAMPT in human peripheral blood cells (PBCs) as well as its involvement in inflammation, glucose and lipid metabolism.

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“…Subjects were recruited from an overfeeding study investigating the effects of a positive energy balance on endocrine factors and on indicators of glucose and lipid metabolism (19,20,22). A total of 69 young men were recruited from the city of St John's (Newfoundland and Labrador, Canada) and the surrounding areas.…”

Section: Methodsmentioning

confidence: 99%

“…Our laboratory and others have shown that changes in nutritional status, such as overfeeding, have major effects on adipose tissue metabolism (19,20), circulating concentrations of adipokines (21), and gene expression profiles (22). A positive energy balance may also influence circulating concentrations of gut hormones, such as PYY, and subsequently affect appetite.…”

Section: Introductionmentioning

confidence: 99%

Serum peptide YY in response to short-term overfeeding in young men

Cahill

Shea

Randell

et al. 2011

The American Journal of Clinical Nutrition

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Background: Peptide YY (PYY), a gut hormone that inhibits appetite, has been linked to the development of obesity. Objective: This study investigated the nutritional regulation of PYY after 7 d of overfeeding (70% above normal energy requirements) in normal-weight, overweight, and obese men. Design: Sixty-nine men (aged 19-29 y) participated in the study. We analyzed the relation between fasting serum PYY before and after a 7-d overfeeding challenge in normal-weight, overweight, and obese men. In addition, we analyzed PYY with obesity-related phenotypes including weight, percentage body fat (measured by dual-energy X-ray absorptiometry), body mass index (BMI), total cholesterol, HDL, LDL, glucose, insulin, insulin resistance, and b cell function evaluated by the homeostasis model assessment of insulin resistance (HOMA-IR) and b cell function (HOMA-b) at baseline and in response to the energy surplus. Results: Fasting serum PYY concentrations at baseline were not significantly different between the normal-weight, overweight, and obese subjects on the basis of dual-energy X-ray absorptiometry or BMI. Although the PYY concentration significantly increased due to overfeeding, no differences were observed between adiposity statuses. In addition, basal PYY was negatively correlated with the changes of total cholesterol, HDL, and LDL in normal weight. In addition, the increase in PYY after overfeeding was positively correlated with HDL cholesterol and glucose in normal-weight subjects. Conclusions: Our findings suggest that fasting PYY concentrations are not associated with adiposity status. Moreover, the 7-d overfeeding challenge significantly increased fasting PYY, which is likely a protective response to the positive energy balance.Am J Clin Nutr 2011;93:741-7.

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Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men

Abstract: Visfatin is down-regulated by overfeeding. Under physiologic conditions, visfatin does not appear to control glucose metabolism but may play a regulatory role in lipid metabolism.

Cited by 87 publications

References 34 publications

Stężenie wisfatyny u osób z otyłością w zależności od obecności świeżo wykrytych zaburzeń gospodarki węglowodanowej

Stężenie wisfatyny u osób z otyłością w zależności od obecności świeżo wykrytych zaburzeń gospodarki węglowodanowej

Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity

Serum peptide YY in response to short-term overfeeding in young men

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