Serum visfatin and vaspin levels in prepubertal children: effect of obesity and weight loss after behavior modifications on their secretion and relationship with glucose metabolism

Abstract

Objective: To investigate the impact of obesity, weight loss and oral glucose ingestion on serum visfatin and vaspin levels in prepubertal children. Subjects and methods: A total of 100 prepubertal obese Caucasian children (OB) and 42 controls (C) were studied. The OB group was studied at baseline and after moderate (n ¼ 46) and extensive (n ¼ 14) body mass index (BMI) reduction by conservative treatment, undergoing body composition studies (dual-energy X-ray absorptiometry) and oral glucose tolerance tests (OGTTs). Serum visfatin and vaspin levels were studied throughout the OGTT, as were their relationships with insulin, leptin, leptin soluble receptor (sOB-R), adiponectin (total and high molecular weight), resistin, interleukin-6 (IL-6) and tumor necrosis factor-a levels at every time point. Results: OB had higher visfatin (Po0.001), but similar vaspin than C. BMI reduction decreased visfatin levels (Po0.001), with BMI, waist circumference and the surrogate markers of body fat (leptin and sOB-R) showing significant correlations (Po0.05) with this peptide, but not with vaspin. Visfatin and vaspin decreased during the OGTT (Po0.001). Weight reduction did not alter visfatin dynamics in the OGTT, but decreased the area under the curve (AUC) for vaspin (Po0.001), with a correlation between the AUCs for vaspin and insulin after weight loss (Po0.05). Visfatin levels were positively correlated with resistin and IL-6, after controlling for BMI and HOMA (homeostatic model assessment) index at every time point in the study. Conclusion: Serum visfatin, but not vaspin, levels are influenced by body fat content in obese children, whereas both adipokines are modulated by glucose intake in a BMI-dependent manner.

Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children

“…Some human studies have found that elevated vaspin concentrations are associated with higher body mass index (BMI) and impaired insulin sensitivity [17,18]; however, other studies did not observe this relationship [19]. Several pediatric studies, but not all, illustrated possible relationships between vaspin, insulin sensitivity, and obesity [13,20,21]. Some reported that weight reduction decreased circulating vaspin levels [22][23][24], but others did not [13,25].…”

“…Visfatin is related to several insulin resistant conditions, such as obesity, metabolic syndrome, and dyslipidemia [9][10][11][12][13][14]. Elevated visfatin concentrations were correlated with body fat mass and visfatin levels decrease when weight loss occurs [13,15].…”

Actividad física, ejercicio y deporte en la lucha contra la obesidad infantil y juvenil

“…Además, la hipoadiponectinemia podría jugar un papel en la inflamación asociada a la obesidad en niños y adolescentes (81). La visfatina es otra adipoquina de caracterización más reciente, producida preferentemente en el tejido adiposo visceral, y cuyos niveles se relacionan con el IMC y la concentración de triglicéridos en niños obesos, aunque no muestran correlación con la resistencia a la insulina (82). Se asocia a niveles elevados de factor de necrosis tumoral (TNF)-α e interleucina (IL)-6, siendo un posible marcador de la inflamación asociada a la obesidad infantil (83).…”

“…La vaspina, producida por los adipocitos, y la omentina de las células estromales del tejido adiposo gástrico también podrían desempeñar una función etiológica o moduladora en la patogénesis de la obesidad (86). En niños obesos el contenido de grasa corporal no afecta los niveles de vaspina, aunque sí existe una modulación por la ingesta de glucosa dependiente del IMC (82). En lo que se refiere a la omentina, sus niveles séricos se asocian en niños prepúberes con valores elevados de índice HOMA y niveles de triacilglicerol, pero no con peso o grasa corporal (87).…”

Multiplexed Bead Immunoassays: Advantages and Limitations in Pediatrics

“…This property offers reliable data and could help in the diagnosis and or follow up of pediatric patients. Thus, different studies, clinical trials or monitoring of pediatric patients during disease treatment require the determination of multiple parameters during extended periods of time (Martos-Moreno et al, 2011a). As an example, in the Table 1, we show the effect of weight loss on several adipokines in obese children after dietary intervention.…”