Serum VCAM-1, ICAM-1, and L-selectin levels in children and young adults with chronic renal failure

Musiał, Kinga; Zwołińska, Danuta; Polak−Jonkisz, Dorota; Berny, U; Szprynger, Krystyna; Szczepańska, Maria

doi:10.1007/s00467-004-1691-x

Cited by 34 publications

(28 citation statements)

References 23 publications

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“…Interestingly, sVCAM-1 might be related to certain blood infections in HD patients [17], however, the increase of its serum levels was rather moderate, well below the highest increases in our study. The increased level of sE- and sP-selectin in HD patients in our study is consistent with other reports [6, 14, 18]. …”

Section: Discussionsupporting

confidence: 83%

“…The concentration of sVCAM-1 was commonly found increased in CRF patients on peritoneal dialysis or HD [5, 14]. Contrary to our results, the levels of sVCAM-1 were found increased both in pre-dialysis CRF patients and during dialysis [6], while the concentrations of the adhesion molecules sVCAM-1 and sICAM-1 were raised in CRF patients compared to the control group [15].…”

Section: Discussioncontrasting

confidence: 55%

See 1 more Smart Citation

Increased Levels of Soluble TNF-α Receptors and Cellular Adhesion Molecules in Patients Undergoing Bioincompatible Hemodialysis

Rysz¹,

Majewska²,

Stolarek³

et al. 2006

Am J Nephrol

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Background: The study aimed to differentiate the effects of hemodialysis (HD) and chronic renal failure (CRF) on the levels of circulating tumor necrosis factor-α (TNF-α) and TNF-α receptors p55 and p75, soluble vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1), soluble endothelial-leukocyte adhesion molecule-1 (sE-selectin) and sP-selectin in 18 patients on regular HD treatment with cuprophane membrane in relation to 15 non-dialyzed CRF patients and 15 healthy controls. Methods: The serum concentrations were determined with standard ELISA assays. Results: Blood serum p75 and p55 were approximately tenfold increased in CRF (36.7 ± 6.2 and 27.1 ± 5.6 ng/ml) and HD patients (45.6 ± 18.4 and 28.7 ± 5.9 ng/ml) before the HD session (HD 0), during (HD 20) the session (45.7 ± 18.4 and 28.5 ± 7.3 ng/ml) and after (HD 240) the HD session (52.1 ± 17.4 and 30.9 ± 8.2 ng/ml) in comparison to control values (5.6 ± 1.3 and 2.4 ± 0.8 ng/ml, respectively) (p < 0.01). The highest increment of p75 at the end of HD session (HD 240) was also significantly higher than at preceding time points (HD 0 and 20) (p < 0.05). However, the remaining study parameters did not change during an HD session. Also, there were no relevant changes in TNF-α levels if (HD 0) 22.7 ± 21.5 ng/ml and (HD 240) 21.1 ± 18.9 ng/ml were compared. Chronic HD status was related to the increase of sVCAM-1 and sICAM-1 levels. Prior to HD, T0 sVCAM-1 and sICAM-1 concentrations were 2,180.4 ± 761.8 and 567.3 ± 218.8 ng/ml, during HD (T20): 2,172.7 ± 759.2 and 602.3 ± 379.9 ng/ml, and after HD (T240): 2,401.6 ± 756.4 and 648.3 ± 183.5 ng/ml, respectively (p < 0.05 vs. controls and CRF patients). sVCAM-1 and sICAM-1 serum levels (1,262.2 ± 472.9 and 165.6 ± 50.4 ng/ml) were similar in CRF patients and healthy controls (854.4 ± 241.5 and 217.6 ± 74.2 ng/ml, respectively). Even though serum sE- and sP-selectin in CRF patients did not differ from the control (39.8 ± 21.3 vs. 42.1 ± 18.9 ng/ml and 187.9 ± 66.9 vs. 198.8 ± 62.2 ng/ml, respectively), their levels were increased in HD patients up to 111.9 ± 54.6 and 453.2 ± 231.1 ng/ml in patients prior to HD, 118.7 ± 66.2 and 350.8 ± 114.8 ng/ml during the HD session and then 132.3 ± 61.1 and 368.3 ± 126.6 ng/ml, respectively, after its completion (p < 0.05 in comparison with CRF patients and controls). Conclusions: The increased circulating TNF-α receptors appear more associated with the uremic milieu than HD-related systemic inflammation, whereas increased soluble cellular adhesion molecules in patients undergoing bioincompatible HD may be related to the enhanced systemic inflammation specifically due to maintenance HD.

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Section: Discussionsupporting

confidence: 83%

Section: Discussioncontrasting

confidence: 55%

Increased Levels of Soluble TNF-α Receptors and Cellular Adhesion Molecules in Patients Undergoing Bioincompatible Hemodialysis

Rysz¹,

Majewska²,

Stolarek³

et al. 2006

Am J Nephrol

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“…(33,34) According to M. Zwolinska, in this condition, the synthesis of VCAM-1 is enhanced, triggering several reactions that cause endothelial dysfunction. (35) When measuring serum TnT, we found that in patients with BPV Type 1, TnT level ranged between 0.1 ng/ml and 0.3 ng/ml (0.23±0.12 ng/ml), whereas in patients with other types of BPV, TnT level did not exceed the upper reference limit. This fact indicates a more significant lesion of the myocardium as a target organ in AH patients with BPV Type 1, which is associated with an unfavorable cardiovascular prognosis.…”

Section: Resultsmentioning

confidence: 75%

Relationship Between Within-Visit Blood Pressure Variability and Kidney Function in Patients with Arterial Hypertension

Kravchenko¹,

Chernykh²,

Budnevsky³

et al. 2017

IJBM

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The main purpose of this study was to investigate the features of within-visit blood pressure variability (BPV) in patients with arterial hypertension (AH) and to assess the relationship of those features to impaired renal filtration.Material and Methods: The study included 120 patients with AH Stages I and II (ESH/ESC, 2013): 58(48.3%) men and 62(51.7%) women aged from 22 to 73 years (mean age 58.7±15 years). Average duration of AH was 15.0±6.7 years. BP was measured three times at 2-minute intervals during one visit. Within-visit BPV was evaluated by the presence of an absolute difference (AD) between any two readings of three SBP measurements of more than 5 mmHg. All patients underwent a comprehensive examination, which included blood and urine tests, kidney ultrasound, assessment of blood levels of creatinine and TnT, and calculation of GFR.Results: Depending on the response of BP to repeated measurements, three types of BPV were identified. A prognostically unfavorable type of BPV, which is characterized by SBP-AD > 5 mmHg between the third and first measurements, was identified. Patients of this group had the lowest eGFR value that indicates more pronounced renal damage, and, as a consequence, worse prognosis. Also in these patients, there was an increase in TnT level, which is a predictor of the development of adverse cardiovascular complications. (International Journal of Biomedicine. 2017;7(2):91-95.)

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“…Leukocyte inflammatory responses are based on leukocyte attachment to the endothelium mediated by adhesion molecules such as integrins, selectins and molecules from the immunoglobulin superfamily (ELAM-1, ICAM-1 and VCAM-1) determining subsequent stages of the adhesion cascade [23, 24]. The predominant mechanism of interaction at normal shear rates involves sequential participation of selectins and integrins, whereas at low shear rates adhesion can be supported solely through integrin and ICAM-1.…”

Section: Discussionmentioning

confidence: 99%

Effect of Two Different Dialysis Membranes on Leukocyte Adhesion and Aggregation

Hernández¹,

Palomo²,

Fusté³

et al. 2007

Nephron Clin Pract

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Aims: We evaluated modifications in formation of heterotypic platelet-leukocyte aggregation induced by dialysis through cellulosic or synthetic membranes and evaluated the effects of such procedures promoting adhesive interactions between leukocytes and normal endothelial cells (ECs). Methods: Samples were obtained from arterial and venous lines at baseline, after 15 and 120 min of hemodialysis. Heterotypic aggregation was assessed using flow-cytometric techniques. Experiments to determine leukocyte adhesion to ECs were performed in parallel plate perfusion chambers at 450 s^–1. Results: Patients dialyzed with a cellulosic membrane showed a significantly higher baseline granulocyte heterotypic aggregation (median 22.5%, range 8.6–32%) versus healthy subjects (median 10%, range 3.2–14.6%; p < 0.05). Granulocyte heterotypic aggregation values remained increased throughout the hemodialysis session not only in the arterial line (median 18 and 24.5%, range 7–30 and 8.7–36% at 15 and 2 h, respectively) but also in the venous line (median 20 and 25%, range 8.6–32 and 11.5–35% at 15 min and 2 h, respectively). Basal lymphocytes heterotypic aggregation values observed in uremic patients were 6% (0.1–7.1%) versus 1.0% (0.5–2.8%) in the control group (p < 0.05). The increase remained during the hemodialysis session both in the arterial line (median 5 and 4%, range 0.2–14 and 0.5–7.1 % at 15 min and 2 h, respectively) and in the venous line (median 7 and 7%, range 1.4–14 and 0.5–10.6% at 15 min and 2 h). In contrast, patients dialyzed with a synthetic membrane showed a decreased basal granulocyte heterotypic aggregation compared to healthy subjects (median 3.5 vs. 10%, range 2.8–7 vs. 3.2–14.6%, respectively; p < 0.05). For lymphocytes, basal heterotypic aggregation values were 0.2% (range 0.1–0.5%) in dialyzed patients vs. 0.98% (range 0.5–2.8%) in healthy subjects (p < 0.05), without changes throughout the dialysis session. Changes in leukocyte adhesion during hemodialysis did not reach statistical significance with either hemodialysis membrane. Our studies confirm a differential activation of platelets and leukocytes depending on the nature of the dialysis membranes. However, activation of circulating cellular elements by hemodialysis procedures did not enhance cross-talk interactions between leukocytes and unaltered ECs.

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Serum VCAM-1, ICAM-1, and L-selectin levels in children and young adults with chronic renal failure

Cited by 34 publications

References 23 publications

Increased Levels of Soluble TNF-α Receptors and Cellular Adhesion Molecules in Patients Undergoing Bioincompatible Hemodialysis

Increased Levels of Soluble TNF-α Receptors and Cellular Adhesion Molecules in Patients Undergoing Bioincompatible Hemodialysis

Relationship Between Within-Visit Blood Pressure Variability and Kidney Function in Patients with Arterial Hypertension

Effect of Two Different Dialysis Membranes on Leukocyte Adhesion and Aggregation

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