Serum uromodulin is a predictive biomarker for cardiovascular events and overall mortality in coronary patients

Leiherer, Andreas; Muendlein, Axel; Saely, Christoph H.; Ebner, Janine; Brandtner, Eva-Maria; Fraunberger, Peter; Drexel, Heinz

doi:10.1016/j.ijcard.2016.12.183

Cited by 45 publications

(47 citation statements)

References 24 publications

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“…Value of the data No prospective data on the power of the ratio between serum creatinine and serum uromodulin to predict cardiovascular events were available at present. This data article further proves the association of the creatinine to uromodulin ratio in serum samples with future cardiovascular events as described in the main article [1] by providing additional cox regression models. Whereas the main article [1] has evaluated the performance of uromodulin as a biomarker to predict mortality, this data article contains the c-statistics-based evaluation of the creatinine to uromodulin ratio to predict cardiovascular events and major cardiovascular events.…”

supporting

confidence: 67%

“… This data article further proves the association of the creatinine to uromodulin ratio in serum samples with future cardiovascular events as described in the main article [1] by providing additional cox regression models. Whereas the main article [1] has evaluated the performance of uromodulin as a biomarker to predict mortality, this data article contains the c-statistics-based evaluation of the creatinine to uromodulin ratio to predict cardiovascular events and major cardiovascular events. This data article helps researchers to evaluate the potential of creatinine to uromodulin ratio as a biomarker.…”

supporting

confidence: 67%

supporting

confidence: 67%

“…Uromodulin and creatinine were measured and cardiovascular events were recorded for up to 8 years. This data article is related to a research article titled “Serum Uromodulin is a predictive biomarker for cardiovascular events and overall mortality in coronary patients” [1] .…”

mentioning

confidence: 99%

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Data on the power of the creatinine to uromodulin ratio in serum to predict cardiovascular events in coronary patients

et al. 2017

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Uromodulin is a protein which is produced by the tubular cells of the thick ascending limb in the kidneys and the creatinine to uromodulin ratio in serum recently has attracted interest as a marker of kidney disease. Whether this ratio also is associated with cardiovascular event risk is unknown. This article provides additional data on the association of the creatinine to uromodulin ratio with its power to predict cardiovascular events and major cardiovascular events in coronary patients. In addition, this data article demonstrates the performance of the creatinine to uromodulin ratio as a biomarker using c-statistics. Analyzed data was derived from 529 coronary patients. Uromodulin and creatinine were measured and cardiovascular events were recorded for up to 8 years. This data article is related to a research article titled “Serum Uromodulin is a predictive biomarker for cardiovascular events and overall mortality in coronary patients” [1].

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supporting

confidence: 67%

supporting

confidence: 67%

supporting

confidence: 67%

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confidence: 99%

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Data on the power of the creatinine to uromodulin ratio in serum to predict cardiovascular events in coronary patients

et al. 2017

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“…In the past decade, several genome-wide association studies have identified common variants in the promoter region of the UMOD gene as risk factors for progression to CKD and hypertension [6][7][8][9]. It has also been reported that the serum uromodulin concentration correlates with mortality in patients with cardiovascular disease [10,11]. Moreover, the findings of in vivo studies in an experimental mouse model lacking the uromodulin gene suggest that uromodulin has a renoprotective effect [12,13].…”

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confidence: 99%

Serum uromodulin is a novel predictive marker of renal function in the Japanese population

Usui

Ogawa

Takahashi³

et al. 2020

Preprint

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Background Uromodulin, also known as Tamm-Horsfall protein, is the most abundant protein in urine. It has recently been reported that uromodulin exists in a small amount in blood and that its concentration correlates with the estimated glomerular filtration rate (eGFR). However, its clinical significance has not been clarified and there are no relevant data for the Japanese population. Method First, we generated anti-human uromodulin mouse monoclonal antibodies and established a specific enzyme-linked immunosorbent assay for uromodulin. We then performed an observational clinical study to determine if there was a correlation between serum uromodulin concentration and estimates of kidney function and whether the serum uromodulin value could be a biomarker in clinical nephrology. The clinical study included 308 patients with and without chronic kidney disease and healthy volunteers. Serum concentrations of creatinine, cystatin C, and uromodulin were measured and correlations were sought between the eGFR calculated from the creatinine and cystatin C levels and the serum uromodulin concentration. Results There was a good correlation between the serum uromodulin concentration and the eGFR value calculated from the creatinine (r=0.76) and cystatin C (r=0.79) levels. The mean serum uromodulin level in the group with an eGFR >90 mL/min/1.73 m 2 calculated using cystatin C was significantly higher than that in the group with an eGFR of 80–89 mL/min/1.73 m 2 . Conclusions The serum uromodulin measurement could be a useful biomarker for identification of patients with early deterioration of kidney function.

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Autosomal Dominant Tubulointerstitial Kidney Disease

Wolf

Ariceta²

2022

Pediatric Nephrology

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Serum uromodulin is a predictive biomarker for cardiovascular events and overall mortality in coronary patients

Cited by 45 publications

References 24 publications

Data on the power of the creatinine to uromodulin ratio in serum to predict cardiovascular events in coronary patients

Data on the power of the creatinine to uromodulin ratio in serum to predict cardiovascular events in coronary patients

Serum uromodulin is a novel predictive marker of renal function in the Japanese population

Autosomal Dominant Tubulointerstitial Kidney Disease

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