Serum Uric Acid Levels and the Risk of Obesity: a Longitudinal Population-Based Epidemiological Study

Zheng, Rongjiong; Chen, Changxi; Yang, Tianmeng; Chen, Qingmei; Lu, Rongdan; Mao, Yu

doi:10.7754/clin.lab.2017.170311

Cited by 39 publications

(47 citation statements)

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“… Hypertension was defined as SBP ≥140 mm Hg, DBP ≥90 mm Hg, or current drug use for hypertension in accordance with the criteria of the WHO Obesity was defined as BMI ≥25 kg/m 2 based on the Asia‐Pacific World Health Organization (WHO) criteria Dyslipidemia was defined as TC ≥5.2 mmol/L, TG ≥1.7 mmol/L, LDL‐C ≥ 3.4 mmol/L, or HDL‐C ＜1.0 mmol/L …”

Section: Methodscontrasting

confidence: 56%

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Current status of treatment of type 2 diabetes mellitus in Ningbo, China

Yang

Zheng

Chen

et al. 2018

Clinical Laboratory Analysis

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Background The treatment status of type 2 diabetes mellitus (T2DM) in Ningbo has not been reported in the past. To evaluate the current status of T2DM in Ningbo and provide evidence to formulate more policies, a multicenter investigation was needed. Methods The Ningbo Clinical Research Group of Diabetes constituted nine hospitals. Participants included 3015 patients who visited the nine hospitals from June to December 2016. General characteristics, the medication situation, the laboratory indexes in nearly 3 months consisting of glycosylated hemoglobin level (HbA1c), low‐density lipoprotein cholesterol (LDL‐C), and fasting blood glucose (FBG), and the results of ophthalmologic examination were investigated. The evaluation criteria were defined based on 2013 China guideline for T2DM. Results The 3015 subjects included 1685 men and 1330 women. The average age was 63.3 ± 13.0 years. The prevalence of hypertension and dyslipidemia was 58.7% and 56.7%, respectively. In the examinees, nephropathy appeared in 11.6% and retinopathy in 14.5%. More than half (50.9%) of the subjects were overweight. The achievement rate of blood pressure (BP) was 39.6% (<140/80 mm Hg), FBG was 46.0% (4.4‐7.0 mmol/L), HbA1c was 41.7% (<7.0%), and LDL‐C was 51.7% (<1.8 mmol/L; and if accompanied by CHD, <2.6). Conclusion Ningbo City T2DM status is not optimistic, and there is a big gap with the indicators.

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Section: Methodscontrasting

confidence: 56%

“…World Health Organization (WHO) criteria. 8 3. Dyslipidemia was defined as TC ≥5.2 mmol/L, TG ≥1.7 mmol/L, LDL-C ≥ 3.4 mmol/L, or HDL-C < 1.0 mmol/L.…”

Section: Obesity Was Defined As Bmi ≥25 Kg/m 2 Based On the Asia-pacificmentioning

confidence: 99%

Current status of treatment of type 2 diabetes mellitus in Ningbo, China

Yang

Zheng

Chen

et al. 2018

Clinical Laboratory Analysis

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“…Therefore, the results from these studies may be greatly affected by the heterogeneity of PCOS. Due to the influence of obesity on the SUA level [ 3 , 22 ], the different rates of obesity among the PCOS and control populations influenced these results. Therefore, we used age- and BMI-stratified analyses to further exemplify the contribution of these two key factors on the SUA level.…”

Section: Resultsmentioning

confidence: 99%

“…Uric acid (UA) is an organic acid that is produced during purine nucleotide metabolism. Elevated serum uric acid (SUA) is closely associated with metabolic disorders, including insulin resistance [ 1 ], type 2 diabetes [ 2 ], obesity [ 3 ] and metabolic syndrome [ 4 ]. It has been reported that reproductive hormones affect the SUA level.…”

Section: Introductionmentioning

confidence: 99%

Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome

Pan

Yang

et al. 2018

Reprod Biol Endocrinol

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BackgroundThe prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence of hyperuricemia in PCOS and to determine the influence of reproductive hormones on uric acid concentration.MethodsThis retrospective cross-sectional study was performed at a large reproductive medicine center. Between March 2007 and October 2016, a total of 1,183 women with PCOS and 10,772 women without PCOS were included. PCOS was diagnosed according to the Rotterdam criteria. Anthropometric parameters, blood pressure, uric acid, reproductive hormones, glucose and lipids were measured in all subjects.ResultsThe serum uric acid (SUA) level was higher in women with PCOS than in women without PCOS. The prevalence of hyperuricemia in women with PCOS (25.48%) was significantly higher than that in women without PCOS (8.74%). Analysis stratified for age and body mass index (BMI) showed that both the SUA level and the prevalence of hyperuricemia were higher in women with PCOS of different age and BMI groups than in women without PCOS. After adjusting for age, BMI and estimated glomerular filtration rate (eGFR), logistic regression analysis revealed that the luteinizing/follicle-stimulating hormone (LH/FSH) ratio (odds ratio (OR) = 1.20, 95% CI = 1.01–1.43) and testosterone level (OR = 1.56, 95% CI = 1.27–1.90) were positively associated with the prevalence of hyperuricemia in females with PCOS.ConclusionsThe serum uric acid (SUA) level and the prevalence of hyperuricemia markedly increased in women with PCOS. The testosterone level was positively associated with the SUA level and the prevalence of hyperuricemia in females with PCOS.

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“…Elevated serum uric acid levels are associated with obesity. Longitudinal studies suggest that high serum acid levels increase the risk of obesity . Adipose tissue produces and secretes uric acid through xanthine oxidoreductase and this production is increased in obesity …”

Section: Discussionmentioning

confidence: 99%

Hyperuricemia and acute gout after laparoscopic sleeve gastrectomy

et al. 2019

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The aim of this study was to evaluate the prevalence of hyperuricemia and acute gout after laparoscopic sleeve gastrectomy (LSG). Risk factors for developing gout were also examined.Eighty-five patients underwent LSG were enrolled in this prospective study. Serum uric acid levels, gout attacks and total water levels % derived by bioimpedance were examined pre-operatively and 1 month post-operatively. Hyperuricemia was identified in 30.6% preoperatively and in 18.82% of patients post-operatively. From the patients' group with pre-operative hyperuricemia, 53.9% were normalized, 46.2% had increased uric acid postoperatively while gout was observed in 11.5%. From the patients group without pre-operative hyperuricemia, hyperuricemia and gout were observed in 6.8% and 5.1% post-operatively, respectively. The relative risk for developing hyperuricemia was 6.2 (95% confidence interval[CI] 2.2-17.8) and for developing gout was 2.3 (95% CI 2.2-17.8). Statistical significant differences for gout among the groups with and without gout were indicated concerning preoperative use of medications (P < 0.001), age (P = 0.025), post-operative uric acid levels (P < 0.001) and post-operative total water levels % (P = 0.048). The prevalence of hyperuricemia was 18.8% and gout attack of 7.1% 1 month after LSG. From the cohort of patients with pre-operative hyperuricemia, a significant proportion normalized uric acid, while 11.5% developed gout. Patients without hyperuricemia pre-operatively developed hyperuricemia and gout in 6.8% and 5.1% post-operatively, respectively. The patients who had gout were younger and had 37% water levels post-operatively. K E Y W O R D Sbariatric surgery, gout, hyperuricemia, laparoscopic sleeve gastrectomy

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Serum Uric Acid Levels and the Risk of Obesity: a Longitudinal Population-Based Epidemiological Study

Abstract: Our longitudinal study demonstrated that high serum uric acid levels increase the risk of obesity.

Cited by 39 publications

References 0 publications

Current status of treatment of type 2 diabetes mellitus in Ningbo, China

Current status of treatment of type 2 diabetes mellitus in Ningbo, China

Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome

Hyperuricemia and acute gout after laparoscopic sleeve gastrectomy

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