Serum uric acid levels and hormone therapy type: a retrospective cohort study of postmenopausal women

Jung, Junhee; Song, Gwan Gyu; Lee, Young Ho; Kim, Jae Hoon; Hyun, Myung Han; Choi, Sung Jae

doi:10.1097/gme.0000000000000953

Cited by 31 publications

(19 citation statements)

References 23 publications

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“…This is consistent with several past studies, where it has been shown that men have higher levels of UA than women in blood and saliva (Andreadou et al, 2009;Kivity et al, 2013;Riis et al, 2018;Yang et al, 2019). The reason for this difference is not clear, but possible explanations include alcohol consumption, which is higher in men, and the influence of estrogens to lower UA (Jung et al, 2018;Yang et al, 2019). Next, we found gender differences in the ability of UA to distinguish diagnostic groups.…”

Section: Discussionsupporting

confidence: 92%

Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients

et al. 2020

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Oxidative stress has long been implicated in the pathophysiology and progression of Huntington's disease (HD). Uric acid (UA) is a naturally occurring antioxidant that is present in the brain and periphery. Growing evidence has implicated UA as a molecular biomarker for several neurodegenerative diseases, most notably Parkinson's disease (PD). In this study, we investigated UA levels in clinical samples from HD patients and normal controls (NCs) and assessed potential relationships between UA levels and disease and clinical data. UA levels were measured in plasma (n = 107) and saliva (n = 178) samples from premanifest (pre-HD) and manifest HD patients and control subjects. Gender effects of UA levels were observed in both biofluids, with male patients showing higher UA levels compared to female patients. Comparisons of UA levels across diagnostic groups, separated by gender, revealed that both plasma and salivary UA levels were significantly lower in female pre-HD and manifest HD patients compared to NCs. Salivary levels of UA were also significantly lower in male manifest HD patients versus controls, but not in plasma. Correlations of peripheral UA levels to clinical data also showed differences according to gender. In male HD patients, both plasma and salivary UA levels were significantly negatively correlated with total functional capacity (TFC), while positive correlations were observed with total motor score (TMS). Female HD patients showed a significant positive correlation between plasma UA levels and TMS, while salivary UA levels from female patients were significantly correlated to disease burden. Finally, in a separate cohort, we show that UA levels are decreased in postmortem prefrontal cortical samples (n = 20) from HD subjects compared to matched controls. These findings suggest that decreased levels of UA in the brains of HD patients can be reflected in peripheral fluids, with salivary measures of UA particularly offering significant promise as a potentially relevant, non-invasive biomarker of disease symptoms and burden. Our findings further highlight the impact of sexual dimorphism in HD pathophysiology.

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Section: Discussionsupporting

confidence: 92%

Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients

et al. 2020

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“…Estrogens promote renal uric acid excretion and decrease the level of SUA by suppressing the protein levels of the urate reabsorptive urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) in the proximal tubule, and that of urate efflux transporter ATP-binding cassette sub-family G member 2 (ABCG2) [24]. Postmenopausal hormone use is associated with lower uric acid levels among postmenopausal women [25].…”

Section: Discussionmentioning

confidence: 99%

Gender-specific association between uric acid level and chronic kidney disease in the elderly health checkup population in China

Yang

Zhou²,

Wang

et al. 2019

Renal Failure

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Objective : To evaluate the association between serum uric acid (SUA) levels with CKD in elderly health checkup population and explore the gender difference. Methods: A total of 4242 subjects were included in the cross-sectional study. All of the subjects participated in the annual checkup between June 2016 and June 2017. Chronic kidney disease (CKD) was defined by estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m 2 . We examined the association between SUA levels and CKD. Multivariate binary logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) by comparing association between the SUA level and CKD. The models were adjusted for age, gender, body mass index (BMI), hypertension, diabetes, triglyceride and high-density lipoprotein cholesterol (HDL-C). Result: The prevalence of hyperuricemia was 22.2%, and it was significantly higher in male than in female (25.2% vs. 17%, p < .001). The prevalence of hyperuricemia increased with age, especially in the female. The prevalence of CKD was 27.8% in male and 20.2% in female ( p < .001). Compared with the SUA first quartile, the multivariate-adjusted odds for CKD of fourth quartiles were 6.05 (95%CI: 4.32–8.49) in male and 8.21(95%CI: 5.37–12.54) in female. Conclusion: Our finding showed gender-specific differences in the association between high SUA and an increased risk of CKD in the elderly population. The association of SUA and CKD was independent of other potential confounding factors including age, glucose, hypertension, HDL, TG and BMI.

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“…Hak et al [29] explained the increase in serum UA in women from the United States (US) by menopause and other age-related factors. Estrogen and progestogen therapy in postmenopausal women can dramatically lower serum UA levels [30]. Mumford et al [31] revealed T A B L E 5.…”

Section: Discussionmentioning

confidence: 99%

Sex-speciﬁc in the relationship between hyperuricemia and pulse pressure in non-diabetic Korean adults: the 2017 Korean National Health and Nutrition Examination Survey

2021

JOMH

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Background and objective: The present study assesses the relationship between hyperuricemia and pulse pressure (PP) in non-diabetic Korean adults. Material and methods: Data from 5122 subjects (2251 men and 2871 women) in the seventh Korean National Health and Nutrition Examination Survey (KNHANES VII-2, 2017) were analyzed. Results: Systolic blood pressure (SBP) and PP were signiﬁcant factors determining the odds ratios (ORs) for hyperuricemia (uric acid ≥7.0 mg/dL in men or ≥6.0 mg/dL in women) in men and the overall population. In women, SBP, diastolic blood pressure (DBP), and PP were not signiﬁcant factors determining the OR for hyperuricemia. After adjusting for related variables, the OR of hyperuricemia was signiﬁcantly higher in the high PP group (PP >60.0 mmHg) for men (OR, 1.760; 95% conﬁdence interval [CI], 1.152--2.688) and the overall population (OR, 1.557; 95% CI, 1.132--2.140) compared with the normal PP group, but this trend was not seen in women (OR, 1.060; 95% CI, 0.646--1.740). Conclusions: Hyperuricemia was positively associated with PP in non-diabetic Korean men but not in women.

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Serum uric acid levels and hormone therapy type: a retrospective cohort study of postmenopausal women

Abstract: We attribute our findings to the effects of progestogen, rather than estrogen.

Cited by 31 publications

References 23 publications

Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients

Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients

Gender-specific association between uric acid level and chronic kidney disease in the elderly health checkup population in China

Sex-speciﬁc in the relationship between hyperuricemia and pulse pressure in non-diabetic Korean adults: the 2017 Korean National Health and Nutrition Examination Survey

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