Serum uric acid is independently associated with hypertension in patients with rheumatoid arthritis

Rheumatoid arthritis: is it a coronary heart disease equivalent?

“…However, multivariate analysis in our cohort revealed renal dysfunction in RA associated with classic CVD risk factors such as advanced age and dyslipidaemia, levels of serum uric acid and the presence of extra-articular rheumatoid disease; RA duration and activity, disability and past or present use of nephrotoxic medications were not associated [37 ]. Interestingly, serum uric acid has been shown to independently associate with hypertension [38], renal dysfunction [39] and CVD [40] in patients with RA and may be a common denominator or predictor for CVD and CKD in RA; indeed serum uric acid may be another novel risk factor, alongside systemic inflammation, for CVD in RA [41 ].…”

Cardiovascular risk factors and not disease activity, severity or therapy associate with renal dysfunction in patients with rheumatoid arthritis: Table 1

“…The aetiological role of inflammation in renal impairment has also received considerable attention but again not specifically in patients with RA 7–10. Hyperuricaemia is known to associate with impaired renal function and recent evidence supports the view that uric acid may not just be an innocent bystander but instead may be an active player in the pathogenesis of renal disease11–13 in general, while we have shown that serum uric acid (SUA) independently associates with both hypertension14 and cardiovascular disease (CVD)15 in RA.…”

Subclinical renal dysfunction is independently associated with cardiovascular events in rheumatoid arthritis: the CARRÉ Study

“…First, we were not able to adjust for residual confounding by recently discovered markers of both renal dysfunction and CV disease in patients with RA. One of these is uric acid, which is a predictor of CV disease in patients with RA24 and has been linked with renal dysfunction in such patients 25. Second, we did not use a control population of healthy subjects and therefore were not able to compare the present findings in RA patients with matched non-RA patients.…”