Serum uric acid is associated with non-dipping circadian pattern in young patients (30–40 years old) with newly diagnosed essential hypertension

“…1 In addition, serum UA levels are independently associated with a non-dipping pattern of nocturnal BP. 2,3 Vascular ROS production appears to be one mechanism by which XOR increases BP. 4 These data suggest that high serum levels of UA could contribute to the development and progression of hypertension and chronic kidney disease (CKD).…”

Section: Introductionmentioning

confidence: 99%

Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia

Kario

Nishizawa

Kiuchi³

et al. 2021

J of Clinical Hypertension

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“…Due to the decreased excretion of uric acid in the nighttime, an upward trend may be shown in the serum uric acid. Thus, elevated serum UA levels can affect the development of rising blood pressure value [31]. Experimental studies have shown that raising serum UA can induce hypertension by stimulating oxidative stress, impairing endothelial function, and stimulating the renin angiotensin system [32,33].…”

Section: Discussionmentioning

confidence: 99%

The association of urinary uric acid excretion with ambulatory blood pressure values in patients with chronic kidney disease

Zhou

Zheng

et al. 2020

Clin Hypertens

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Background: To analyze the association between hypertension and urinary uric acid excretion in patients with chronic kidney disease (CKD). Methods: We screened 87 patients who had been admitted at the Dept of Nephrology, Huadong hospital between April 2017 to April 2019 who had completed 24-h ambulatory blood pressure monitoring and retained 24-h urine biochemical test specimens, thirty adult patients (age ≤ 65 years) with CKD 1-2 stages were recruited in the study. Pearson's correlation analysis and multiple linear regression analysis were used to study the correlation of urinary uric acid excretion with ambulatory blood pressure values and the association of morning mean diastolic pressure (mMDP), night mean diastolic pressure (nMDP) and CV of dMSP (coefficient of variation of day mean systolic pressure) with fractional excretion of uric acid (FEua) and uric acid clearance rate (Cur). Independent T test was used to compare the differences of blood pressure values in FEua1 (FEua< 6.0%) and FEua2 (FEua≥6.0%) or Cur1 (Cur < 6.2 ml/min/1.73 m 2 ) and Cur2 (Cur ≥ 6.2 ml/min/1.73m 2 ) groups according to the median of FEua or Cur, respectively. Results: After adjusting for confounding factors, multiple linear regression analysis showed that FEua was positively associated with the mMDP and nMDP, Cur was positively associated with CV of dMSP. Levels of mMDP and nMDP in FEua1 group was lower than that in FEua2 group (both P < 0.05), level of CV of dMSP in Cur2 group were higher than that in Cur1 group (P < 0.01). Conclusions: We demonstrated that there is a positive correlation of FEua with morning and night mean diastolic pressure separately and Cur is positively related to CV of dMSP in CKD population. Monitoring the trend of urinary uric acid, may have a role in the early detection for hypertension or relative risks in the population of CKD.

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Serum uric acid is associated with non-dipping circadian pattern in young patients (30–40 years old) with newly diagnosed essential hypertension

Abstract: Serum UA is independently associated with nondipper circadian pattern in young patients with newly diagnosed essential hypertension.

Cited by 10 publications

References 43 publications

Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review

Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review

Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia

The association of urinary uric acid excretion with ambulatory blood pressure values in patients with chronic kidney disease

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