Serum uric acid is associated with increased risk of posttransplantation diabetes in kidney transplant recipients: a prospective cohort study

Sotomayor, Camilo G.; Sokooti, Sara; Bustos, Nelly; Nolte, Ilja M.; Gomes-Neto, António W; Erazo, Marcia; Gormaz, Juan G.; Berger, Stefan P.; Navis, Gerjan; Rodrigo, Ramón; Dullaart, Robin P. F.; Bakker, Stephan J. L.

doi:10.1016/j.metabol.2020.154465

Cited by 5 publications

(4 citation statements)

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“…During those years of follow-up, all participants were invited to complete physical examinations, health-related questionnaires, and laboratory tests, and they repeated these tests annually. For this study, 349,524 subjects were excluded based on the following criteria: (i) those who were aged <18 years and ≥ 60 years (considering the diameter of the retinal arteriolar is narrower in the elderly and the degenerative sclerosis in older persons (26)); (ii) those had no information of eye diagnosis during exposure period (from January 1, 2006, through December 31, 2010) (Figure 1) and had no information of SUA or body mass index (BMI) during baseline period (from January 1, 2010, through December 31, 2010); (iii) those suffered from retinal arteriosclerosis or hypertension or diabetes during exposure period (because the previous study reported that high SUA levels significant increase the incident hypertension (10,11,(27)(28)(29)(30), and SUA has been confirmed to play an essential role in the pathogenesis of diabetes (13,14), what's more hypertension and diabetes would accelerate the process of retinal arteriosclerosis (2,3); and (iv) those had less than 3 uric acid measurements during exposure period or had no data of eye diagnosis during outcome period (from January 1, 2011, through December 31, 2019). Thus, a total of 4,324 participants were ultimately included in the analysis of SUA trajectories.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…Accumulating epidemiological and clinical evidence has demonstrated that elevated SUA is associated with a variety of cardiovascular disorders, including hypertension, diabetes, coronary heart disease, metabolic syndrome, etc. (10)(11)(12)(13)(14)(15)(16)(17). However, limited research has been performed on the associations of SUA with arteriosclerosis, especially retinal microvessels.…”

Section: Introductionmentioning

confidence: 99%

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Sex-specific association of serum uric acid trajectories with risk of incident retinal arteriosclerosis in Chinese population: A population-based longitudinal study

Geng

Feng²,

Ji³

et al. 2023

Front. Cardiovasc. Med.

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BackgroundThe impact of serum uric acid (SUA) trajectories on the development of retinal arteriosclerosis is uncertain. The purpose of this study was to identify adult SUA trajectories by sex and determine their association with risk of retinal arteriosclerosis.MethodsIn this longitudinal study, 4,324 participants who were aged between 18 and 60 years without retinal arteriosclerosis at or before baseline (from January 1, 2010, through December 31, 2010) were included. Group-based trajectory modeling was used to identify SUA trajectories during the exposure period (from January 1, 2006, through December 31, 2010). Cox proportional-hazards models were applied to evaluate the associations between SUA trajectories and the risk of incident retinal arteriosclerosis during the outcome period (from January 1, 2011, through December 31, 2019).Results4 distinct SUA trajectories were identified in both women and men: low, moderate, moderate-high, and high. During a median follow-up of 9.54 years (IQR 9.53–9.56), 97 women and 295 men had developed retinal arteriosclerosis. In the fully adjusted model, a significant association between the moderate-high SUA trajectory group and incidence of retinal arteriosclerosis was observed only in men (HR: 1.76, 95% CI: 1.17–2.65) compared with the low trajectory group, but not in women (HR: 0.77, 95% CI: 0.39–1.52). Also, the high SUA trajectory group had the highest risk with an adjusted HR of 1.81 (95% CI, 1.04–3.17) in men. However, they did not exhibit a substantially increased risk in women.ConclusionHigher SUA trajectory groups were significantly associated with an increased risk of incident retinal arteriosclerosis in men but not in women.

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Section: Study Design and Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex-specific association of serum uric acid trajectories with risk of incident retinal arteriosclerosis in Chinese population: A population-based longitudinal study

Geng

Feng²,

Ji³

et al. 2023

Front. Cardiovasc. Med.

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“…The result of a meta-analysis on 7140 kidney recipients indicates that acute rejection, tacrolimus administration, history of hypertension, viral infection (hepatitis B and C viruses), polycystic kidney disease, body mass index (BMI) (4), older age and family history of diabetes are risk factors for the development of NODAT (5). It has also been recently reported that high serum uric acid is connected with an increased risk of NODAT developing, independent of proven risk factors (6). Predisposing genetic factors as risk factors are also participated in the development of NODAT (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

IL-17 gene polymorphism (rs763780) in kidney recipients with post-transplant diabetes

et al. 2022

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Introduction: New-onset diabetes mellitus after transplantation (NODAT) is a common complication of organ transplantation, leading to allograft dysfunction. Genetic alterations of inflammatory cytokines have been reported to be associated with glucose homeostasis and diabetes. Objectives: This study evaluated the rs763780 polymorphism of IL-17F gene in transplant recipients with and without NODAT. Patients and Methods: The present retrospective study was conducted on ninety-one patients who have had a kidney transplant for at least three months. Patients were divided into two subgroups; recipients with NODAT (n=32) and kidney recipients without NODAT (n=59). After DNA extraction from patients’ blood samples, amplification and evaluation of specific polymorphism of the gene were performed using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Clinical and demographic data of patients were collected. Results: The NODAT was detected in 81.3% (n=26) of TT genotype carriers, 12.5% of TC genotype carriers and 6.3% of CC genotype carriers. No statistically significant differences between the studied groups in the frequency of C and T alleles and the distribution of the abovementioned genotypes were detected (P≥0.721). In the NODAT group, graft rejection and age of patients were higher significantly (P≤0.017). Conclusion: No significant correlation between the incidence of diabetes and rs763780 polymorphism of IL-17F gene was observed.

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“…Although kidney transplantation aims to restore kidney function, it should be noted that it incompletely mitigates ongoing mechanisms of disease, including inflammation, oxidative stress, and impaired metabolic homeostasis ( 5 ). In outpatient, otherwise stable KTR, an aggregate of factors inherent to the post-kidney transplant milieu such as chronic low-grade immunologic response to the kidney graft, long-term nephrotoxicity associated to the use of calcineurin inhibitors (CNI), and elevation of serum uric acid (SUA), resulting in renal function impairment, contribute to perpetuate redox imbalance, and chronic low-grade inflammation ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

Polyphenols and Novel Insights Into Post-kidney Transplant Complications and Cardiovascular Disease: A Narrative Review

Bustos

Sotomayor

Pol

et al. 2021

Front. Cardiovasc. Med.

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Kidney transplantation is the preferred treatment for end-stage kidney disease. It is, however, not devoid of complications. Delayed graft function related to ischemia-reperfusion injury (IRI), calcineurin inhibitor (CNI) nephrotoxicity, diabetes, and a particularly high-rate cardiovascular disease (CVD) risk, represent important complications following kidney transplantation. Oxidative stress and chronic low-grade inflammation are mechanisms of disease incompletely abrogated in stable kidney transplant recipient (KTR), contributing to the occurrence of these complications. Polyphenols, bioactive compounds with recognized antioxidant and anti-inflammatory properties have been strongly associated with prevention of CVD in the general population and have been shown to decrease IRI and antagonize CNI nephrotoxicity in animal experimental models, therefore they may have a role in prevention of complications in KTR. This narrative review aims to summarize and discuss current evidence on different polyphenols for prevention of complications, particularly prevention of CVD in KTR, pointing toward the need of further studies with potential clinical impact.

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Serum uric acid is associated with increased risk of posttransplantation diabetes in kidney transplant recipients: a prospective cohort study

Cited by 5 publications

References 62 publications

Sex-specific association of serum uric acid trajectories with risk of incident retinal arteriosclerosis in Chinese population: A population-based longitudinal study

Sex-specific association of serum uric acid trajectories with risk of incident retinal arteriosclerosis in Chinese population: A population-based longitudinal study

IL-17 gene polymorphism (rs763780) in kidney recipients with post-transplant diabetes

Polyphenols and Novel Insights Into Post-kidney Transplant Complications and Cardiovascular Disease: A Narrative Review

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