Serum uric acid is associated with increased risk of idiopathic venous thromboembolism in high HDL-C population: A case-control study

Abstract

Many studies have indicated that metabolic disorders are positively correlated with idiopathic venous thromboembolism (VTE), whereas the risk factor serum uric acid (SUA) for idiopathic VTE has yet to be investigated. In this retrospective case-control study, 276 idiopathic VTE patients and 536 gender- and age-matched control subjects were included. The subjects in the case and control groups exhibiting common known VTE risk factors and the patients with a first VTE onset in one month were excluded. For the control group, primary and secondary VTE patients were excluded. High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, total cholesterol, fasting blood glucose, and current smoking were significantly associated with idiopathic VTE in the univariate analysis. Hyperuricemia was detected in 56/276 (20.29%) idiopathic patients compared with 71/536 (13.25%) in the control group. HDL-C was considered the most prominent interactive factor for SUA in idiopathic VTE by the interaction analysis. After testing for the interaction terms, SUA was closely associated with idiopathic VTE in the high HDL-C population (P=0.0026 for interaction), while there was no such correlation in the low HDL-C group. The results indicated no obvious correlation between triglyceride and hypertension to idiopathic VTE. In conclusion, SUA is closely associated with an increased risk of idiopathic VTE in the high HDL-C population. The abnormality of SUA may act as an important linkage between atherosclerosis and idiopathic VTE through HDL-C.

Serum Albumin and Circulating Metabolites and Risk of Venous Thromboembolism: A Two-Sample Mendelian Randomization Study

“…Several cohort studies showed that serum uric acid (SUA) level is an independent risk factor of VTE (42)(43)(44). Though our MR data does not show a significant association between high level with VTE, the p-value is around the border of suggestive significance (p = 0.078) and suggested a trend toward increasing VTE risk.…”

Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review

“…In 200 hypertensive patients that have normal treadmill exercise test, patients with erectile dysfunction have significantly higher SUA [182] . In persons with elevated level of HDLc, SUA is associated with an increased risk of idiopathic venous thromboembolism [183] . In patients with hypertrophic cardiomyopathy, SUA is a significant predictor of adverse outcome [184] .…”

Could be serum uric acid a risk factor for thrombosis and/or uveitis in Behcet’s disease?

“…17–19 Previous studies showed the in vitro role of UA in endothelial dysfunction and it is shown that it could inhibit endothelial release of nitric oxide and block endothelial cell proliferation in vitro. 20–22 Uric acid and thrombosis are also being investigated in a variety of recent studies 23 but we could not able to find a study about anterior uveitis and uric acid. Behcet's disease is a syndrome characterized by inflammation, so we examined whether anterior uveal involvement, a part of the inflammatory side of this disease, is directly related to a parameter known to be associated with inflammatory processes such as uric acid.…”